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83 results for “Chondrosarcoma”
Raw Data for the article: High-Resolution Secretome Analysis of Chemical Hypoxia Treated Cells Identifies Putative Biomarkers of Chondrosarcoma
<p>Chondrosarcoma is the second most common bone tumor, accounting for 20% of all cases. Little is known about the pathology and molecular mechanisms involved in the development and in the metastatic process of chondrosarcoma. As a consequence, there are no approved therapies for this tumor and surgical resection is the only treatment currently available. Moreover, there are no available biomarkers for this type of tumor, and chondrosarcoma classification relies on operator-dependent histopathological assessment. Reliable biomarkers of chondrosarcoma are urgently needed, as well as greater understanding of the molecular mechanisms of its development for translational purposes. Hypoxia is a central feature of chondrosarcoma progression. The hypoxic tumor microenvironment of chondrosarcoma triggers a number of cellular events, culminating in increased invasiveness and migratory capability. Herein, we analyzed the effects of chemically-induced hypoxia on the secretome of SW 1353, a human chondrosarcoma cell line, using high-resolution quantitative proteomics. We found that hypoxia induced unconventional protein secretion and the release of proteins associated to exosomes. Among these proteins, which may be used to monitor chondrosarcoma development, we validated the increased secretion in response to hypoxia of glyceraldehyde 3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme well-known for its different functional roles in a wide range of tumors. In conclusion, by analyzing the changes induced by hypoxia in the secretome of chondrosarcoma cells, we identified molecular mechanisms that can play a role in chondrosarcoma progression and pinpointed proteins, including GAPDH, that may be developed as potential biomarkers for the diagnosis and therapeutic management of chondrosarcoma.</p>
Testing the Combination of Belinostat and SGI-110 (Guadecitabine) or ASTX727 for the Treatment of Unresectable and Metastatic Conventional Chondrosarcoma
ClinicalTrials.gov study NCT04340843. IPD Sharing: YES. Countries: 1. Publications: 1.
Vismodegib in Treating Patients With Advanced Chondrosarcomas
ClinicalTrials.gov study NCT01267955. IPD Sharing: Not stated. Countries: 1. Publications: 1.
AG-120 in People With IDH1 Mutant Chondrosarcoma
ClinicalTrials.gov study NCT04278781. IPD Sharing: YES. Countries: 1. Publications: 1.
Apatinib for Inoperable Advanced Chondrosarcoma
ClinicalTrials.gov study NCT04260113. IPD Sharing: NO. Countries: 1. Publications: 3.
Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine
ClinicalTrials.gov study NCT00592748. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Synovial Chondrosarcoma: a Single Institution Experience
ClinicalTrials.gov study NCT03776942. IPD Sharing: Not stated. Countries: 1. Publications: 5.
A Phase II Study of EVEROLIMUS in Patients With Primary or Relapsed Chondrosarcomas
ClinicalTrials.gov study NCT02008019. IPD Sharing: Not stated. Countries: 1. Publications: 26.
Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Low and Inter-mediate Grade Chondrosarcoma of the Skull Base
ClinicalTrials.gov study NCT01182753. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Study on Trabectedin in Advanced Rearranged Mesenchymal Chondrosarcoma
ClinicalTrials.gov study NCT04305548. IPD Sharing: NO. Countries: 1. Publications: 5.
Gemcitabine and Docetaxel in Treating Patients With Recurrent Osteosarcoma (Closed to Accrual as of 12/21/06) or Ewing's Sarcoma or Unresectable or Locally Recurrent Chondrosarcoma
ClinicalTrials.gov study NCT00073983. IPD Sharing: Not stated. Countries: 0. Publications: 1.
A Study of Anlotinib Combined With or Without PD-1 Antibody on Unresectable High-grade Chondrosarcoma
ClinicalTrials.gov study NCT05193188. IPD Sharing: NO. Countries: 1. Publications: 1.
Hypofractionated Protontherapy in Chordomas and Chondrosarcomas of the Skull Base
ClinicalTrials.gov study NCT05861245. IPD Sharing: UNDECIDED. Countries: 1. Publications: 41.
Understanding Engagement Trends in Chondrosarcoma Clinical Trials
ClinicalTrials.gov study NCT06029478. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen
ClinicalTrials.gov study NCT06127407. IPD Sharing: YES. Countries: 17. Publications: 1.
Trial of Pazopanib in Patients With Solitary Fibrous Tumor and Extraskeletal Myxoid Chondrosarcoma
ClinicalTrials.gov study NCT02066285. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Proton Therapy for Chordomas and/or Chondrosarcomas
ClinicalTrials.gov study NCT00797602. IPD Sharing: UNDECIDED. Countries: 1. Publications: 17.
X-rays radiomics-based machine learning classification of atypical cartilaginous tumour and high-grade chondrosarcoma of long bones
<p>Deidentified dataset, which includes raw data used in the study:</p> <p>Gitto S, Annovazzi A, Nulle K, et al. X-rays radiomics-based machine learning classification of atypical cartilaginous tumor and high-grade chondrosarcoma of long bones. EBioMedicine 2024; 101:105018. doi: 10.1016/j.ebiom.2024.105018.</p>
Testing Atezolizumab in People 2-17 Years Old With Clear Cell Sarcoma or Advanced Chondrosarcoma
ClinicalTrials.gov study NCT04458922. IPD Sharing: YES. Countries: 2. Publications: 0.
Study of Pazopanib in the Treatment of Surgically Unresectable or Metastatic Chondrosarcoma
ClinicalTrials.gov study NCT01330966. IPD Sharing: Not stated. Countries: 2. Publications: 0.
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OpenNeuro
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