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ShareScore release 0.9.0
Dataset results
12 results for “Clonal Architecture”
Input data of manuscript "CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells"
<p>This is the directory containing input data necessary to reproduce analyses presented in the manuscript:</p> <blockquote> <p><strong>CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells</strong><br> Shadi Darvish Shafighi, Szymon M Kiełbasa, Julieta Sepúlveda Yáñez, Ramin Monajemi, Davy Cats, Hailiang Mei, Roberta Menafra, Susan Kloet, Hendrik Veelken, Cornelis A.M. van Bergen, Ewa Szczurek</p> </blockquote>
Autopolyploid establishment depends on life history strategy and the mating outcomes of clonal architecture
<p><span>Polyploidy is a significant component in the evolution of many taxa, particularly plant groups. However, new polyploids face substantial fitness disadvantages due to a lack of same-cytotype mates, and the factors promoting or preventing polyploid establishment in natural populations are often unclear. We develop spatially explicit agent-based simulation models to test the hypothesis that a perennial life history and clonal propagation facilitate the early stages of polyploid establishment and persistence. Our models show that polyploids are more likely to establish when they have longer lifespans than diploids, especially when self-fertilization rates are high. Polyploids that combine sexual and clonal reproduction can establish across a wide range of life histories, but their success is moderated by clonal strategy. By tracking individuals and mating events we reveal that clonal architecture has a substantial impact on the spatial structure of the mixed diploid-polyploid population during polyploid establishment: altering patterns of mating within or between cytotypes via geitonogamous self-fertilization, the mechanisms through which polyploid establishment proceeds, and the final composition of the polyploid population. Overall, our findings provide novel insight into the role of clonal structure in modulating the complex relationship between polyploidy, perenniality, and clonality; and offer testable predictions for future empirical work. </span></p>
Data from: Epigenetically distinct synaptic architecture in clonal compartments in the teleostean dorsal pallium
<p><span>The dorsal telencephalon (i.e. the pallium) exhibits high anatomical diversity across vertebrate classes. The non-mammalian dorsal pallium accommodates various compartmentalized structures among species.</span> <span>The developmental, functional and evolutional diversity of the dorsal pallium remain unillustrated. Here, we analyzed the structure and epigenetic landscapes of cell lineages in the telencephalon of medaka fish (<em>Oryzias latipes</em>) which possesses a clearly delineated dorsal pallium (Dd2). We found that pallial anatomical regions, including Dd2, are formed by mutually exclusive clonal units, and that each pallium compartment exhibits a distinct epigenetic landscape. In particular, Dd2 possesses a unique open chromatin pattern that preferentially targets synapse-related genes. Indeed, Dd2 shows a high density of synapses. Finally, we identified several transcription factors as candidate regulators. Taken together, we suggest cell lineages are the basic components for the functional regionalization in the pallial anatomical compartments, and that their changes has been the driving force for evolutionary diversity.</span></p>
Data from: Epigenetically distinct synaptic architecture in clonal compartments in the teleostean dorsal pallium
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Autopolyploid establishment depends on life history strategy and the mating outcomes of clonal architecture
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A Prospective Trial to Study the Evolution of Clonal Architecture of Tumors From Patients Treated With Molecular Targeted Agents
ClinicalTrials.gov study NCT02517892. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Clonal Architecture of ASXL1-mutated Myelofibrosis
ClinicalTrials.gov study NCT05710211. IPD Sharing: NO. Countries: 1. Publications: 0.
Longitudinal Genome Wide Analysis of Chronic Lymphocytic Leukemia Reveals Complex Evolution of Clonal Architecture at Disease Progression and at the Time of Relapse
GEO Series GSE30217. Homo sapiens. 54 samples. Type: Genome variation profiling by genome tiling array.
Deconvoluting clonal and cellular architecture in IDH-mutant Acute Myeloid Leukemia
GEO Series GSE230559. Homo sapiens. 130 samples. Type: Expression profiling by high throughput sequencing; Other.
Architecture of the neutrophil compartment in mice [scRNA-seq clonal]
GEO Series GSE301173. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Xenografting of advanced stage breast cancer preserves the genomic and clonal architecture and captures luminal tumors harboring mutations and gene rearrangements in ESR1
GEO Series GSE46604. Homo sapiens. 272 samples. Type: Expression profiling by array.
Genetic variegation of clonal architecture and stem cells in leukaemia
GEO Series GSE24412. Homo sapiens. 8 samples. Type: Genome variation profiling by SNP array; SNP genotyping by SNP array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.