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Dataset results
13 results for “Common human disease”
A genomic compendium of cultivated human gut fungi characterizes the gut mycobiome and its relevance to common diseases
<p><span>Morphological and scanning electron microscopy images of 206 fungal species cultivated from human feces. </span></p>
Common palm civets (Paradoxurus hermaphroditus) are positively associated with humans and forest degradation with implications for seed dispersal and zoonotic diseases
<p>Habitat loss and degradation can undermine wildlife communities and ecosystem functioning. However, certain generalist wildlife species like mesopredators and omnivores can exploit these disturbed habitats, sometimes leading to population increases (e.g., "mesopredator release" in degraded areas). Although mesopredator release may cause negative effects on food webs and zoonotic disease management, some disturbance-tolerant species may help perpetuate important ecological interactions, such as seed dispersal.</p> <p>We evaluated the habitat associations of common palm civets (Paradoxurus hermaphroditus), which are widespread generalist mesopredators in Southeast Asia. Common palm civets are also high-quality seed dispersers, and potential zoonotic disease hosts.</p> <p>We used published and new camera trapping data to map their probability of presence across Southeast Asia and evaluate regional-scale associations between capture rates and habitat variables such as elevation, ecoregion intactness, and Human Footprint Index, among others. We also assessed the influence of habitat variables on their relative abundance at the local scale.</p> <p>At the regional scale, we found that common palm civets showed significant positive associations with landscapes characterized by lower ecoregion intactness, higher Human Footprint Index, and lower elevations. At the local scale, their relative abundance showed a significant positive association with higher Human Footprint Index, but only to a certain point, after which it started decreasing. They also favored lower elevations at the local scale.</p> <p>These multi-scale results indicate that common palm civets' abundance can increase under certain levels of human disturbances, consistent with the "mesopredator release" hypothesis. This suggests they may be crucial seed dispersers in degraded forest landscapes, especially where more sensitive seed dispersers have disappeared. Our results are also consistent with previous studies reporting that habitat degradation increases populations of potential zoonotic disease hosts, and thus risks of transmission to humans.</p>
The effects of exploratory behavior on physical activity in a common animal model of human disease, zebrafish (Danio rerio)
<p>Zebrafish (Danio rerio) are widely accepted as a multidisciplinary vertebrate model for neurobehavioral and clinical studies, and more recently have become established as a model for exercise physiology and behavior. Individual differences in activity level (e.g., exploration) have been characterized in zebrafish, however, how different levels of exploration correspond to differences in motivation to engage in swimming behavior has not yet been explored. We screened individual zebrafish in two tests of exploration: the open field and novel tank diving tests. The fish were then exposed to a tank in which they could choose to enter a compartment with a flow of water (as a means of testing voluntary motivation to exercise). After a 2-day habituation period, behavioral observations were conducted. We used correlative analyses to investigate the robustness of the different exploration tests. Due to the complexity of dependent behavioral variables, we used machine learning to determine the personality variables that were best at predicting swimming behavior. Our results show that contrary to our predictions, the correlation between novel tank diving test variables and open field test variables was relatively weak. Novel tank diving variables were more correlated with themselves than open field variables were to each other. Males exhibited stronger relationships between behavioral variables than did females. In terms of swimming behavior, fish that spent more time in the swimming zone spent more time actively swimming, however, swimming behavior was inconsistent across the time of the study. All relationships between swimming variables and exploration tests were relatively weak, though novel tank diving test variables had stronger correlations. Machine learning showed that three novel tank diving variables (entries top/bottom, movement rate, average top entry duration) and one open field variable (proportion of time spent frozen) were the best predictors of swimming behavior, demonstrating that the novel tank diving test is a powerful tool to investigate exploration. Increased knowledge about how individual differences in exploration may play a role in swimming behavior in zebrafish is fundamental to their utility as a model of exercise physiology and behavior.</p>
Common palm civets (Paradoxurus hermaphroditus) are positively associated with humans and forest degradation with implications for seed dispersal and zoonotic diseases
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The effects of exploratory behavior on physical activity in a common animal model of human disease, zebrafish (Danio rerio)
Open the record for dataset details and reuse information.
A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PDKCC during chondrogenesis [HiChIP]
GEO Series GSE212226. Homo sapiens. 25 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PDKCC during chondrogenesis
GEO Series GSE212234. Homo sapiens. 35 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Deep transcriptomic analysis of human vascular cells identifies novel risk genes for common vascular diseases
GEO Series GSE111120. Homo sapiens. 38 samples. Type: Expression profiling by high throughput sequencing.
A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PDKCC during chondrogenesis [ChIP-seq]
GEO Series GSE212225. Homo sapiens. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Cell intrinsic differences in human ALS motor neuron subtypes reveal a common disease mechanism and targeting lipid metabolites
GEO Series GSE173115. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Cell intrinsic differences in human ALS motor neuron subtypes reveals a common disease mechanism and targeting lipid metabolites
GEO Series GSE132972. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Unified Mouse and Human Kidney Single-Cell Expression Atlas Reveal Commonalities and Differences in Disease States
GEO Series GSE220493. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
“Bench-to-Bedside and Back” analysis of NAFLD model reveals common transcriptomic shifts between mouse and human during disease progression
GEO Series GSE159911. Mus musculus. 152 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.