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28 results for “Coxiella burnetii”
Supplementary dataset to the publication "Ultraviolet C inactivation of Coxiella burnetii for production of a structurally preserved whole cell vaccine antigen"
<p>The dataset supplements the journal article "Ultraviolet C inactivation of <em>Coxiella burnetii </em>for production of a structurally preserved whole cell vaccine antigen" published by Katja Mertens-Scholz, Amira A. Moawad, Elisabeth M. Liebler-Tenorio, Andrea Helming, Jennifer Andrack, Peter Miethe, Heinrich Neubauer, Mathias W. Pletz and Ina-Gabriele Richter in the journal BMC Microbiology (https://doi.org/10.1186/s12866-024-03246-z). The file "NMII 100µW" contains all data regarding inactivation of <em>C. burnetii</em> Nine Mile phase II with 100µW in a time dependent manner. The file "NMI 100 and 250µW" contains all data regarding inactivation of <em>C. burnetii</em> Nine Mile phase I with 100µW and 250µW in a time dependent manner. The file "surviving fraction" contains all data regarding inactivation of <em>C. burnetii </em>Nine Mile phase I and II after UVC treatment. The file "serology" contains all data obtained from ELISA experiments. The file "diameter" contains all data regarding the bacterial diameter after UVC treatment.</p>
Fig. 1 in Molecular survey on the occurrence of avian haemosporidia, Coxiella burnetii and Francisella tularensis in waterfowl from central Italy
Fig. 1. Phylogenetic tree showing the Leucocytozoon sequencing results.
Data from: Genome-wide epitope mapping reveals significant diversity in antibody responses to Coxiella burnetii vaccination and infection
<p><em>Coxiella burnetii</em> is an important zoonotic bacterial pathogen of global importance, causing the disease Q fever in a wide range of animal hosts. Ruminant livestock, in particular sheep and goats, are considered the main reservoir of infection. Vaccination is a key control measure and two commercial vaccines based on formalin-inactivated<em> C. burnetii </em>bacterins are currently available. However, their deployment is limited due to significant reactogenicity in individuals previously sensitized to <em>C. burnetii </em>antigens. Furthermore, these vaccines interfere with available serodiagnostic tests which are also based on <em>C. burnetii</em> bacterin preparations. Subunit vaccines based on recombinant proteins offer significant advantages, as they can be designed to reduce reactogenicity and can be co-designed with defined antigen serodiagnostic tests to allow discrimination between vaccinated and infected individuals. This study aimed to investigate the diversity of antibody responses to <em>C. burnetii </em>vaccination and/or infection in cattle, goats, humans, and sheep through genome-wide linear epitope mapping to identify candidate vaccine and diagnostic antigens within the predicted bacterial proteome. Using high-density peptide microarrays, we analyzed the seroreactivity in 156 serum samples from vaccinated and infected individuals to peptides derived from 2,092 ORFs in the <em>C. burnetii</em> genome. We found significant diversity in the antibody responses within and between species and across different <em>C. burnetii</em> exposure statuses. However, <em>C. burnetii</em> exposure did result in more uniform seroreactivity across species. Through the implementation of three different vaccine candidate methods, we identified 493 candidate protein antigens for protein subunit vaccine design or serodiagnostic, out of which 65 have been previously described. This is the first study to investigate seroreactivity against the entire <em>C. burnetii </em>genome presented as overlapping linear peptides and provides the basis for selection of antigen targets for next generation Q fever vaccines and diagnostic tests.</p>
Data from: Genome-wide epitope mapping reveals significant diversity in antibody responses to Coxiella burnetii vaccination and infection
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Data from: Genotyping of Coxiella burnetii from domestic ruminants and human in Hungary: indication of various genotypes
Background: Information about the genotypic characteristic of Coxiella burnetii from Hungary is lacking. The aim of this study is to describe the genetic diversity of C. burnetii in Hungary and compare genotypes with those found elsewhere. A total of 12 samples: (cattle, n = 6, sheep, n = 5 and human, n = 1) collected from across Hungary were studied by a 10-loci multispacer sequence typing (MST) and 6-loci multiple-locus variable-number of tandem repeat analysis (MLVA). Phylogenetic relationships among MST genotypes show how these Hungarian samples are related to others collected around the world. Results: Three MST genotypes were identified: sequence type (ST) 20 has also been identified in ruminants from other European countries and the USA, ST28 was previously identified in Kazakhstan, and the proposed ST37 is novel. All MST genotypes yielded different MLVA genotypes and three different MLVA genotypes were identified within ST20 samples alone. Two novel MLVA types 0-9-5-5-6-2 (AG) and 0-8-4-5-6-2 (AF) (Ms23-Ms24-Ms27-Ms28-Ms33-Ms34) were defined in the ovine materials correlated with ST28 and ST37. Samples from different parts of the phylogenetic tree were associated with different hosts, suggesting host-specific adaptations. Conclusions: Even with the limited number of samples analysed, this study revealed high genetic diversity among C. burnetii in Hungary. Understanding the background genetic diversity will be essential in identifying and controlling outbreaks.
Q fever in Egypt: Epidemiological survey of Coxiella burnetii specific antibodies in cattle, buffaloes, sheep, goats and camels
<p>Dataset complementing the publication "Q fever in Egypt: Epidemiological survey of <em>Coxiella burnetii</em> specific antibodies in cattle, buffaloes, sheep, goats and camels" (PLOS ONE, 2018).</p>
Data from: Genotyping of Coxiella burnetii from domestic ruminants and human in Hungary: indication of various genotypes
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Data from: When outgroups fail; phylogenomics of rooting the emerging pathogen, Coxiella burnetii
Rooting phylogenies is critical for understanding evolution, yet the importance, intricacies and difficulties of rooting are often overlooked. For rooting, polymorphic characters among the group of interest (ingroup) must be compared to those of a relative (outgroup) that diverged before the last common ancestor (LCA) of the ingroup. Problems arise if an outgroup does not exist, is unknown, or is so distant that few characters are shared, in which case duplicated genes originating before the LCA can be used as proxy outgroups to root diverse phylogenies. Here, we describe a genome-wide expansion of this technique that can be used to solve problems at the other end of the evolutionary scale: where ingroup individuals are all very closely related to each other, but the next closest relative is very distant. We used shared orthologous single nucleotide polymorphisms (SNPs) from 10 whole genome sequences of Coxiella burnetii, the causative agent of Q fever in humans, to create a robust, but unrooted phylogeny. To maximize the number of characters informative about the rooting, we searched entire genomes for polymorphic duplicated regions where orthologs of each paralog could be identified so that the paralogs could be used to root the tree. Recent radiations, such as those of emerging pathogens, often pose rooting challenges due to a lack of ingroup variation and large genomic differences with known outgroups. Using a phylogenomic approach, we created a robust, rooted phylogeny for C. burnetii.
Data from: When outgroups fail; phylogenomics of rooting the emerging pathogen, Coxiella burnetii
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Sex-related differences in gene expression following Coxiella burnetii infection: potential role of circadian rhythm
GEO Series GSE21065. Mus musculus. 36 samples. Type: Expression profiling by array.
Genotyping of Coxiella burnetii strains collection
GEO Series GSE31543. Coxiella burnetii. 52 samples. Type: Genome variation profiling by array.
CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death
GEO Series GSE292317. Homo sapiens. 78 samples. Type: Expression profiling by high throughput sequencing.
Primary Murine Macrophages as a Tool for Virulence Factor Discovery in Coxiella burnetii
GEO Series GSE208339. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Mast cell cytonemes as a defense mechanism against Coxiella burnetii
GEO Series GSE111971. Homo sapiens. 12 samples. Type: Expression profiling by array.
Vascular Infections Caused by Coxiella Burnetii
ClinicalTrials.gov study NCT07305402. IPD Sharing: NO. Countries: 1. Publications: 0.
Prevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France
ClinicalTrials.gov study NCT03334019. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Coxiella burnetii, the agent of Q fever, persists in adipocytes
GEO Series GSE46335. Mus musculus. 7 samples. Type: Expression profiling by array.
Granulomatous response to Coxiella burnetii, the agent of Q fever: Activation of type I interferon-related genes
GEO Series GSE37666. Homo sapiens. 12 samples. Type: Expression profiling by array.
Human THP-1 Cells: Uninfected vs. Coxiella burnetii NMII infected compared to Uninfected with Chloramphenicol vs. Coxiella burnetii NMII infected with Chloramphenicol
GEO Series GSE23665. Homo sapiens. 12 samples. Type: Expression profiling by array.
Developmental transitions of Coxiella burnetii grown in axenic media
GEO Series GSE51135. Coxiella burnetii; Rickettsia rickettsii; Chlamydia muridarum; Staphylococcus epidermidis RP62A; Chlamydia caviae GPIC; Borreliella burgdorferi B31; Chlamydia trachomatis D/UW-3/CX; Staphylococcus haemolyticus JCSC1435; Chlamydia pneumoniae AR39; Coxiella burnetii RSA 493; Granulibacter bethesdensis; Staphylococcus epidermidis ATCC 12228; Staphylococcus aureus subsp. aureus MW2. 8 samples. Type: Expression profiling by array.
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