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11 results for “Creutzfeldt–Jakob disease”
dataset related to article: "PMCA-Based Detection of Prions in the Olfactory Mucosa of Patients With Sporadic Creutzfeldt-Jakob Disease"
<ol> <li>ESTIMATING PRION CONCENTRATION IN THE OM OF SCJD MM1, MV2 AND VV2 PATIENTS BY MEANS OF QUANTITATIVE PMCA (QPMCA)</li> <li>EVALUATION OF THE BIOCHEMICAL PROPERTIES OF PMCA GENERATED PRODUCTS</li> <li>PMCA ANALYSIS OF SCJD BRAIN HOMOGENATES</li> <li>PMCA ANALYSIS OF SCJD OLFACTORY MUCOSA</li> <li>RT-QuIC ANALYSIS OF OM AND BH OF SCJD PATIENTS AND CONTROLS</li> <li>WESTERN BLOT ANALYSIS OF BRAIN HOMOGENATES</li> <li>STATISTICAL ANALYSIS</li> </ol>
CJD (Creutzfeldt-Jakob Disease) Quinacrine Study
ClinicalTrials.gov study NCT00183092. IPD Sharing: Not stated. Countries: 1. Publications: 6.
A Natural History Study of Preclinical Genetic Creutzfeldt-Jakob Disease (CJD)
ClinicalTrials.gov study NCT05746715. IPD Sharing: NO. Countries: 1. Publications: 2.
Data from: Validation and utilization of amended diagnostic criteria in Creutzfeldt-Jakob Disease surveillance
Objective: To validate an amended protocol for clinical diagnosis of sporadic Creutzfeldt-Jakob Disease (sCJD) including Real-Time Quaking-induced Conversion (RT-QuIC) and to observe its utilization in CJD surveillance. Methods: In the framework of a prospective epidemiological study, all neuropathological confirmed sCJD cases that received CSF RT-QuIC analysis during diagnostic work up (n=65) and a control group of non- CJD cases (n=118) were selected to investigate the accuracy of an amended diagnostic protocol. The patients had been referred to the German National Reference Center for Transmissible Spongiform Encephalopathies. The influence of the amended protocol on incidence figures was evaluated in the context of three years of surveillance activity (screened cases using 14-3-3 test: n=18.789, highly suspicious cases of CJD: n=704). Annual incidences were calculated using current criteria and the amended protocol. Results: The amended protocol showed a sensitivity of 97% and a specificity of 99%. When it was applied to all suspected cases that were referred to the reference center, the assessed incidence of CJD increased from 1.7 to 2.2 per million in 2016. Conclusion: CJD surveillance remains challenging as information from external healthcare institutions can be limited. RT-QuIC shows excellent diagnostic accuracy when applied in the clinical setting to symptomatic patients. Data for RT-QuIC alone, when applied as a general screening test, are not available yet. We propose an amended research protocol which improves early and accurate clinical diagnosis of sCJD during surveillance activities. The utilization of this protocol will probably lead to a significant increase of the incidence rate.
Data from: Validation and utilization of amended diagnostic criteria in Creutzfeldt-Jakob Disease surveillance
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Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt-Jakob disease
GEO Series GSE156994. Homo sapiens. 219 samples. Type: Methylation profiling by genome tiling array.
Analysis of RNA expression profiles identifies dysregulated vesicle trafficking pathways in Creutzfeldt-Jakob Disease
GEO Series GSE124571. Homo sapiens. 21 samples. Type: Expression profiling by array.
A blood miRNA signature associates with sporadic Creutzfeldt-Jakob disease diagnosis
GEO Series GSE140069. Homo sapiens. 105 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Gene expression in the brain of sporadic Creutzfeldt-Jakob disease patients (CJD), and normal controls (CT)
GEO Series GSE160208. Homo sapiens. 47 samples. Type: Expression profiling by array.
Evaluation of Diagnostic Criteria for Creutzfeldt Jakob Disease
ClinicalTrials.gov study NCT04944732. IPD Sharing: NO. Countries: 0. Publications: 0.
Expression data from parietal cortex of G114V genetic Creutzfeldt-Jakob disease patient
GEO Series GSE30643. Homo sapiens. 2 samples. Type: Expression profiling by array.
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