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73 results for “Cyanoacrylate”
Cyanoacrylate glue in breast surgery: the GLUBREAST Trial Can cyanoacrylate glue reduce seroma after axillary dissection?
<p>In 2018, the National Cancer Institute of Naples has launched the GLUBREAST Trial to verify the efficacy of cyanoacrylate sealing glue to reduce seroma after axillary dissection in breast surgery. The glue is a synthetic sealant, CE approved for internal human uses and surgical procedures. The assumed mechanism of action in breast surgery is that the glue create a seal coating in the operative field to occlude lymphatic leaks and limit seroma formation. Methods The trial included one hundred-eighty patients scheduled for breast conserving surgery or total mastectomy without reconstruction.Ninety-one were randomized to receive suction drain and sealant glue after axillary dissection (Experimental Arm), whereas eighty-nine patients (Control Arm) received suction drain without glue. Statistics A multivariable mixed effect model on presence of liquid drained and volume drained were calculated. Stratified models by visits were performed. Results The trial ended in June 2022. Older age was associated with a higher volume of seroma drained per day (β 0.30; 95% CI: 0.00‐0.60). 5‐U increase in Body Mass Index was associated with higher daily drained seroma volume in patients underwent breast conserving surgery (β 5.0; 95% CI: 0.62‐9.4), but not in patients underwent<br>mastectomy (β 2.5; 95% CI: ‐3.6‐8.6). We did not find statistically significant differences in presence of liquid drained and volume<br>drained among the study groups. An advantage for the Experimental Arm was observed from 3 th and 4 th to 5 th outpatient<br>visits without reaching a statistical significance (p=0.069 and p=0.072, respectively), so far 5% of patients in the Experimental<br>Group had clinical benefit from the glue.Conclusions. Data in the literature come from case series, and surgeons need higher level<br>of evidence to drive surgical decision-making and choose proper devices to increase patient quality of life. GLUBREAST randomized trial tested the efficacy of cyanoacrylate sealing glue to prevent post-operative seroma in breast surgery. Although only a small number of patients benefited from sealant application, we regret to say this trial has some limitation, i.e. the prolonged presence of suction drain. Further research is warranted to better clarify the benefit of cyanoacrylate glue in breast surgery.</p>
Preparation techniques of thin cyanoacrylate adhesive films for interface analysis
<p>For understanding the interactions between adhesives and different surfaces, the in-situ characterization of the interface is essential. Especially for highly reactive cyanoacrylates, better known as instant adhesives, the adhesion mechanism is poorly understood because, among other things, the characterization of the interface is difficult. The objective of this work is to evaluate the methods of thermal evaporating and spin coating to produce nm-thin, homogeneous films of cyanoacrylate. The aim is to enable spectroscopic analysis of the interface in the future.</p>
Bonding mechanism of cyanoacrylate on SiO2 and Au: Spectroscopic studies of the interface
<p>Cyanoacrylates form a highly reactive class of adhesives that develop significant adhesive strength to surfaces within a few seconds. Despite their commercial use, the exact bonding mechanism is virtually unknown. In the present work, we spin coat nm-thin films of ethyl cyanoacrylate on the two model substrates gold and silicon dioxide. The objective of the studies is to identify chemical interactions at the interface between adhesive and metal (oxide) which are possible reasons for film adhesion on the macroscopic scale. For this purpose, thin films of ethyl cyanoacrylate are investigated by X-Ray photoelectron spectroscopy.</p>
Impact of Cyanoacrylate Glue on PICC Line Dressing Care
ClinicalTrials.gov study NCT05246709. IPD Sharing: YES. Countries: 1. Publications: 6.
Study of the Combination of a Cyanoacrylate and Surgical Solutions in Reducing Skin Flora Contamination
ClinicalTrials.gov study NCT00467857. IPD Sharing: Not stated. Countries: 5. Publications: 6.
A Comparison of 2-octyl Cyanoacrylate Skin Adhesive and Polyester Mesh for Wound Closure in Total Knee Arthroplasty, A Randomized Controlled Study
ClinicalTrials.gov study NCT06232018. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Carvedilol as an Adjunct to Endoscopic Cyanoacrylate Injection for Secondary Prophylaxis of Gastric Variceal Bleeding
ClinicalTrials.gov study NCT02504723. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Mechanochemical Ablation Compared to Cyanoacrylate Adhesive
ClinicalTrials.gov study NCT03392753. IPD Sharing: NO. Countries: 1. Publications: 2.
Tissue Glue (Cyanoacrylate) Versus Conventional Suture in Kidney Donors
ClinicalTrials.gov study NCT01521871. IPD Sharing: Not stated. Countries: 1. Publications: 4.
2-octyl Cyanoacrylate for Closure of Urethrocutaneous Fistula.
ClinicalTrials.gov study NCT02115191. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effectivenes of Cyanoacrylate (Glubran 2®) in Reducing Seroma Formation in Breast Cancer Patients Post-Axillary Dissection
ClinicalTrials.gov study NCT02141373. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Tissue Adhesive Glue Modified Cyanoacrylate (Glubran® 2) in Soft Pancreas
ClinicalTrials.gov study NCT07155525. IPD Sharing: NO. Countries: 1. Publications: 2.
Angiography for Evaluation of the Feeder Vessel in EUS-guided Coils and Cyanoacrylate Therapy for Gastric Varices
ClinicalTrials.gov study NCT03277937. IPD Sharing: UNDECIDED. Countries: 1. Publications: 27.
Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate
ClinicalTrials.gov study NCT07230509. IPD Sharing: NO. Countries: 1. Publications: 4.
Cyanoacrylate Closure Versus Surgical Stripping for Incompetent Saphenous Veins
ClinicalTrials.gov study NCT03835559. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Use of Cyanoacrylate in Healing and Pain in the Palatal Donor Site of Connective Tissue Grafts
ClinicalTrials.gov study NCT06116539. IPD Sharing: NO. Countries: 1. Publications: 6.
Comparison of Cyanoacrylate Adhesives to Sutures in the Palate After Connective Tissue Graft
ClinicalTrials.gov study NCT02935426. IPD Sharing: UNDECIDED. Countries: 1. Publications: 26.
Effect of Cyanoacrylate and Concentrated Growth Factor on Palatal Donor Site
ClinicalTrials.gov study NCT06459947. IPD Sharing: NO. Countries: 1. Publications: 2.
Evaluation of EUS in Preventing Rebleeding After Endoscopic Cyanoacrylate Injection for Gastric Varices
ClinicalTrials.gov study NCT05515861. IPD Sharing: YES. Countries: 1. Publications: 16.
Effectiveness of Cyanoacrylate Glue in the Fixation of Midline and Peripherally Inserted Central Catheters in Hospitalized Adult Patients: Randomised Clinical Trial (CIANO-ETI)
ClinicalTrials.gov study NCT05299060. IPD Sharing: YES. Countries: 1. Publications: 26.
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