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18 results for “Cyr61”
Data from: Potential role of Cyr61 induced degeneration of human Müller cells in diabetic retinopathy
The degeneration of Müller cells has been recognized to involve in the pathogenesis of diabetic retinopathy. However, the mechanism is not yet clear. This study is to explore the potential role of Cyr61, a secreted signaling protein in extracellular matrix, in inducing human Müller cell degeneration in diabetic retinopathy (DR). Twenty patients with proliferative diabetic retinopathy (PDR) and twelve non-diabetic patients were recruited for this study. Vitreous fluid was collected during vitrectomy surgery for Cyr61 ELISA. Human Müller cell line MIO-M1 were cultured to be subconfluent, and then treated with glucose (0–20 mM) or Cyr61 (0–300 ng/ml). Cyr61 expression induced by increasing concentrations of glucose was evaluated by RT-qPCR and Western blot. Effects of Cyr61 on Müller cells viability, migration and apoptosis were observed by MTT assay, Transwell assay, and TUNEL assay. Vitreous Cyr61 levels were observed to be 8-fold higher in patients with PDR (3576.92±1574.58 pg/mL), compared with non-diabetic controls (436.14±130.69 pg/mL). Interestingly, the active PDR group was significantly higher than the quiescent PDR group (P<0.01). In retinal Müller cells culture, high glucose significantly and dose-dependently elevated Cyr61 expression at both mRNA and protein levels. Cyr61 at high concentrations dose-dependently inhibited the viability and migration of Müller cells. TUNEL assay further revealed that high concentration of Cyr61 significantly promoted the cell apoptosis. In conclusion, these findings demonstrated for the first time that the expression of Cyr61 was elevated by high glucose in Müller cells, and Cyr61 inhibited cell viability and migration while induced apoptosis, suggesting the potential role of Cyr61 in Müller cell degeneration. The elevated Cyr61 levels in vitreous fluid of PDR patients further support its role in diabetic retinopathy (DR).
Data from: Potential role of Cyr61 induced degeneration of human Müller cells in diabetic retinopathy
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Cyr61 promotes CD204 expression and migration of macrophages via MEK/Erk pathway in the microenvironment of human esophageal squamous cell carcinoma
GEO Series GSE59471. Homo sapiens. 2 samples. Type: Expression profiling by array.
Downregulation of CYR61 promotes hepatocellular carcinoma progression by ameliorating the protumor functions of TGF-β/YAP and impeding the activation of stromal hepatic stellate cells
GEO Series GSE222402. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq of CYR61-treated THP1 human monocytes
GEO Series GSE233125. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq of CYR61-treated human umbilical vein endothelial cells
GEO Series GSE222101. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Upregulation of CYR61 by TGF-β and YAP signaling exerts a counter-suppression of hepatocellular carcinoma
GEO Series GSE240760. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq of human umbilical vein endothelial cells co-incubated with CYR61-treated mouse bone marrow-derived macrophages
GEO Series GSE222099. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
CYR61 orchestrates NASH fibrosis through SYK-NFκB-PDGF signaling in monocyte-derived macrophages [bulk RNA-seq]
GEO Series GSE199637. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq of CYR61-treated murine bone marrow-derived macrophages
GEO Series GSE222100. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
CYR61 orchestrates NASH fibrosis through SYK-NFκB-PDGF signaling in monocyte-derived macrophages [10X single-cell RNA-seq]
GEO Series GSE199638. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
The Expression and Effect of Cyr61 in Urinary Tract Transitional Cell Carcinoma
ClinicalTrials.gov study NCT01189838. IPD Sharing: Not stated. Countries: 1. Publications: 0.
CYR61 orchestrates NASH fibrosis through SYK-NFκB-PDGF signaling in monocyte-derived macrophages [HIVE single-cell RNA-seq]
GEO Series GSE199639. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
CYR61 orchestrates NASH fibrosis through SYK-NFκB-PDGF signaling in monocyte-derived macrophages
GEO Series GSE199640. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Pregnancy Outcomes in Mouse Dams Exposed to Arsenic: The Role of CYR61 m6A Modification
GEO Series GSE222092. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Tetracycline-Inducible Cyr61 effect on LN229 glioma cells
GEO Series GSE29384. Homo sapiens. 6 samples. Type: Expression profiling by array.
The Diagnostic Role of Cystein-rich Protein 61 (Cyr61) in Acute Kidney Injury: Correlation With the Harmonic Analysis of Arterial Pressure Pulse Waves.
ClinicalTrials.gov study NCT01876134. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Bulk RNA-seq of: HUVECs co-incubated with CYR61-treated mouse bone marrow-derived macrophages; CYR61-treated murine bone marrow-derived macrophages; CYR61-treated HUVECs; and CYR61-treated human THP1
GEO Series GSE222102. Homo sapiens; Mus musculus. 69 samples. Type: Expression profiling by high throughput sequencing.
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