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184
datasets available to search
ShareScore release 0.9.0
Dataset results
184 results for “Cytomegalovirus infection”
Efficacy and Safety Study of Maribavir Treatment Compared to Investigator-assigned Treatment in Transplant Recipients With Cytomegalovirus (CMV) Infections That Are Refractory or Resistant to Treatmen
ClinicalTrials.gov study NCT02931539. IPD Sharing: YES. Countries: 14. Publications: 6.
A Study of Maribavir in Japanese People With Cytomegalovirus (CMV) Infection
ClinicalTrials.gov study NCT05137717. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study of Maribavir Compared to Valganciclovir to Treat Cytomegalovirus Infections in People Who Have Received Stem Cell Transplants
ClinicalTrials.gov study NCT02927067. IPD Sharing: YES. Countries: 23. Publications: 3.
Raw data for the article: Successful Use of Heterologous CMV-Reactive T Lymphocyte to Treat Severe Refractory Cytomegalovirus (CMV) Infection in a Liver Transplanted Patient: Correlation of the Host Antiviral Immune Reconstitution with CMV Viral Load and CMV miRNome
<p>Cytomegalovirus (CMV) infection is the most significant viral infection in hosts with compromised immune systems as solid organ transplant patients. Despite significant progress being made in the prevention of CMV disease in these patients, further therapeutic strategies for CMV disease and for the CMV reactivation prevention are needed. Here, we describe the outcome of the infusion of in vitro expanded CMV-reactive T-cells, taken from a healthy CMV-seropositive donor, in a liver-transplanted recipient with a refractory recurrent CMV. In this particular case, adoptive transfer of allogenic CMV-reactive T-lymphocytes resulted in the clearance of CMV infection and resolution of the pathological manifestations of the patient. In the study we also investigated circulating miRNAs, both cellular and viral, as potential biomarkers during the course of CMV infection. The results indicate that the infusion of allogenic CMV-reactive T-cells can be an effective strategy to treat CMV infection recurrence when the generation of autologous virus specific T cell clones is not possible.</p>
A Study in Adolescent Females to Explore Cytomegalovirus Infection
ClinicalTrials.gov study NCT01691820. IPD Sharing: NO. Countries: 3. Publications: 1.
Extension of Letermovir (LET) From Day 100 to Day 200 Post-transplant for the Prevention of Cytomegalovirus (CMV) Infection in Hematopoietic Stem Cell Transplant (HSCT) Participants (MK-8228-040)
ClinicalTrials.gov study NCT03930615. IPD Sharing: YES. Countries: 6. Publications: 2.
Study of CMX001 to Prevent/Control Cytomegalovirus Infection in R+ Hematopoietic Stem Cell Transplant Recipients
ClinicalTrials.gov study NCT00942305. IPD Sharing: NO. Countries: 1. Publications: 3.
MK-8228 (Letermovir) in the Prevention of Human Cytomegalovirus (CMV) Infection and Disease in Adult Japanese Kidney Transplant Recipients (MK-8228-042)
ClinicalTrials.gov study NCT04129398. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study to Evaluate the Safety and Tolerability, Pharmacokinetics, and Antiviral Activity of Maribavir for the Treatment of Cytomegalovirus (CMV) Infection in Children and Adolescents Who Have Receive
ClinicalTrials.gov study NCT05319353. IPD Sharing: YES. Countries: 11. Publications: 1.
A Study for Kidney Transplant Recipients at High-Risk of Cytomegalovirus Infection
ClinicalTrials.gov study NCT04225923. IPD Sharing: NO. Countries: 2. Publications: 2.
Cytogam Administration in Abdominal Organ Transplant Recipients at High Risk for Cytomegalovirus Infection
ClinicalTrials.gov study NCT01509404. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Letermovir Treatment for Refractory or Resistant Cytomegalovirus Infection
ClinicalTrials.gov study NCT03728426. IPD Sharing: NO. Countries: 1. Publications: 2.
Study of the Transmission of Cytomegalovirus (CMV) Infection From Mother to Foetus
ClinicalTrials.gov study NCT01251744. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Does cytomegalovirus infection increase the risk of tuberculosis in UK children?
Open the record for dataset details and reuse information.
Unravelling molecular signatures and causal factors underlying latent Cytomegalovirus infection among people living with HIV
<p>CMV seropositivity does not lead to severe <span>pathology </span>in healthy individuals, but it contributes to medical complications in people living with HIV (PLHIV). This study provides a comprehensive evaluation of how CMV <span>seropositivity</span> shapes the immune system of 1887 PLHIV, by utilizing multi-omics and deep immune phenotyping dataset<span>s</span>. We observed prominent CMV-induced signatures at the DNA methylome and transcriptome levels <span>that were </span>related to immune functions in PLHIV. High FCRL6 expression is a promising biomarker for immune activation in latent CMV infection, underlied by the demethylation of FCRL6 and up-regulation of gene expression and plasma protein concentrations in CMV<span>-seropositive</span><span> </span>PLHIV. Furthermore, the host genetics-driven elevation in both gene and protein expression of FCRL6 was associated with latent CMV infection. We also identified a significant CMV-susceptibility locus associated with cytokine production capacity and protein abundance.</p>
Supplementary Materials for Discovery of Hub Genes and Construction of Competitive Endogenous RNA Network in Human Cytomegalovirus Infection Using Computational and Bioinformatics Tools
<p><span>Table S1: List of targeted genes by 41 differentially expressed microRNAs (DEMs) agreed in Targetscan and miRDB; Table S2: Significant biological process (BP) of 144 genes associated with Human Cytomegalovirus (HCMV); Table S3: Significant cellular components (CC) of 144 genes associated with HCMV; Table S4: Enriched molecular function (MF) of 144 genes associated with HCMV; Table S5: Pathways significantly affected by 144 genes in HCMV; Figure S1: Number of interactions for each gene in protein-protein interaction (PPI) network.</span></p>
Valganciclovir to Prevent Cytomegalovirus Infection in Patients Following Donor Stem Cell Transplantation
ClinicalTrials.gov study NCT00016068. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Impact of CMV-Specific Immune Reconstitution at the End of Letermovir Prophylaxis on the Development of Late Cytomegalovirus Infection in Hematopoietic Stem Cell Transplant Recipients (INMUNOEND)
ClinicalTrials.gov study NCT06814301. IPD Sharing: YES. Countries: 1. Publications: 1.
Letermovir (MK-8228) Versus Placebo in the Prevention of Clinically-Significant Cytomegalovirus (CMV) Infection in Adult, CMV-Seropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients (MK-
ClinicalTrials.gov study NCT02137772. IPD Sharing: YES. Countries: 0. Publications: 4.
Adoptive Transfer of pp65-specific T Cells for the Treatment of Refractory Cytomegalovirus (CMV) Infection
ClinicalTrials.gov study NCT02346617. IPD Sharing: Not stated. Countries: 1. Publications: 10.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.