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201 results for “DHA”
Molecular dynamics simulations of the interaction of wild type human CYP2J2 with DHA (POSES 1-4)
<p><strong>Description of files in this dataset:</strong></p> <p><strong>MD_wt_CYP2J2_DHA_StateX_repeatY.zip</strong> : Series of zipped directories for molecular dynamics simulations of docosahexaenoic acid (DHA) in the active site of wild type CYP2J2. X is the docking pose number that constitutes the starting point of the simulation (the 4 lowest-energy poses from docking were selected as the starting points of the simulations - this dataset is State(pose) 1). Y is the repeat (each simulation was repeated 3 times, hence there are 3 repeats per pose). </p> <p>Each directory contains the following sub-directories:</p> <p>001.leap : Amber parameter and coordinate files; PDBs; ligands; leap commands</p> <p>002.min : Minimisation stage</p> <p>003.heat : Heating stage</p> <p>004.equil: Equilibration stage</p> <p>005.md : Production stage</p> <p>006.analysis : Basic energy graphs</p> <p>007.cpptraj: Contains only the file strip.md.nc (Amber trajectories stripped of water in netCDF format)</p>
Fig. 3 in An Effectiveness Of Artemia Nauplii Enrichment With Polyunsaturated Fatty Acids Using A Supplement Easy Dha Selco
Fig. 3. Lipase (А) та α-amylase (B) activities in Artemia nauplii at the different schemes of bioencapsulation with Easy DHA Selco.
Fig. 2 in An Effectiveness Of Artemia Nauplii Enrichment With Polyunsaturated Fatty Acids Using A Supplement Easy Dha Selco
Fig. 2. Total proteolytic activity in Artemia nauplii at the different pH during bioencapsulation with Easy DHA Selco (A – pH 4.8; B – pH 7.4; C – pH 9.0).
Fig 2 in Docosahexaenoic Acid (DHA) Reduces LPSInduced Inflammatory Response Via ATF3 Transcription Factor and Stimulates Src/ Syk Signaling-Dependent Phagocytosis in Microglia
<p>Proteome profiler arrays (A and B) and expression of ATF3 gene (C) in microglia. Representative array membranes (A) and the relative levels of cytokines and chemokines (B) in microglia preincubated with 20 μM DHA and next treated with 10 ng/ml LPS.</p>
Fig 1 in Docosahexaenoic Acid (DHA) Reduces LPSInduced Inflammatory Response Via ATF3 Transcription Factor and Stimulates Src/ Syk Signaling-Dependent Phagocytosis in Microglia
<p>Viability of microglia incubated with various concentration of DHA for 12 h (A) and LPS for 2.5 h (B). Viability of microglia incubated with 20 μM DHA followed by 10 ng/ ml LPS treatment (C).</p>
Lipidomic datasets for: Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism
<p>Transmembrane protein 135 (TMEM135) is thought to participate in the cellular response to increased intracellular lipids yet no defined molecular function for TMEM135 in lipid metabolism has been identified. In this study, we performed a lipid analysis of tissues from <em>Tmem135</em> mutant mice and found striking reductions of docosahexaenoic acid (DHA) across all <em>Tmem135</em> mutant tissues, indicating a role of TMEM135 in the production of DHA. Since all enzymes required for DHA synthesis remain intact in <em>Tmem135</em> mutant mice, we hypothesized that TMEM135 is involved in the export of DHA from peroxisomes. The <em>Tmem135</em> mutation likely leads to the retention of DHA in peroxisomes, causing DHA to be degraded within peroxisomes by their beta-oxidation machinery. This may lead to generation or alteration of ligands required for the activation of peroxisome proliferator-activated receptor a (PPARa) signaling, which in turn could result in increased peroxisomal number and beta-oxidation enzymes observed in <em>Tmem135</em> mutant mice. We confirmed this effect of PPARa signaling by detecting decreased peroxisomes and their proteins upon genetic ablation of <em>Ppara</em> in <em>Tmem135</em> mutant mice. Using <em>Tmem135</em> mutant mice, we also validated the protective effect of increased peroxisomes and peroxisomal beta-oxidation on the metabolic disease phenotypes of leptin mutant mice which has been observed in previous studies. Thus, we conclude that TMEM135 has a role in lipid homeostasis through its function in peroxisomes.</p>
Double Blind, Crossover Study of Fish Oil [EPA and DHA] for Intractable Partial Seizures
ClinicalTrials.gov study NCT00871377. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Effect of EPA and DHA in the Inflammation and Metabolic Disorders in DMD/DMB Patients
ClinicalTrials.gov study NCT01826422. IPD Sharing: NO. Countries: 1. Publications: 5.
DHA For The Treatment of Pediatric Concussion Related to Sports Injury
ClinicalTrials.gov study NCT01903525. IPD Sharing: NO. Countries: 1. Publications: 1.
DHA (Docosahexaenoic Acid), an Omega 3 Fatty Acid, in Slowing the Progression of Alzheimer's Disease
ClinicalTrials.gov study NCT00440050. IPD Sharing: Not stated. Countries: 1. Publications: 8.
DHA and X-Linked Retinitis Pigmentosa
ClinicalTrials.gov study NCT00100230. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Growth and Adiposity in Newborns: The Influence of Prenatal Docosahexaenoic Acid (DHA) Supplementation
ClinicalTrials.gov study NCT03310983. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Kansas University DHA Outcome Study (KUDOS) Follow-Up
ClinicalTrials.gov study NCT02487771. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Bridging the Docosahexaenoic Acid (DHA) Gap: The Effects of Omega-3 Fatty Acid Supplementation in Premature Infants
ClinicalTrials.gov study NCT01908907. IPD Sharing: NO. Countries: 1. Publications: 2.
Safety and Effectiveness of Omega 3-Fatty Acids, EPA Versus DHA, for the Treatment of Major Depression
ClinicalTrials.gov study NCT00361374. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Investigate the Effect of Food on Pharmacokinetics of Total EPA and Total DHA of AZD0585 in Healthy Male Japanese Subjects
ClinicalTrials.gov study NCT02372344. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effects of DHA on Periodontitis
ClinicalTrials.gov study NCT01976806. IPD Sharing: Not stated. Countries: 1. Publications: 2.
DHA Supplementation for Lactating Mothers
ClinicalTrials.gov study NCT01732874. IPD Sharing: Not stated. Countries: 1. Publications: 1.
DHA Supplementation and Pregnancy Outcome
ClinicalTrials.gov study NCT00266825. IPD Sharing: UNDECIDED. Countries: 1. Publications: 12.
Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malaria
ClinicalTrials.gov study NCT02802501. IPD Sharing: YES. Countries: 1. Publications: 1.
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