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Dataset results
493 results for “Diarrhea”
What drives poor quality of care for child diarrhea? Experimental evidence from India
<p>Most healthcare providers in developing countries know that oral rehydration salts (ORS) is a lifesaving treatment for child diarrhea, yet few prescribe it. This know-do gap has puzzled experts for decades and has cost millions of lives. Using several randomized controlled trials among private providers in 253 towns in India, we estimated the extent to which ORS under-prescription is driven by financial incentives to sell more lucrative medicines, stock-outs of ORS, and provider perceptions that patients do not want ORS. We found that patients expressing a preference for ORS increased ORS prescribing by 27 percentage points. Eliminating stock-outs increased ORS provision by 6.8 percentage points. Eliminating financial incentives to sell medicines had no effect on average but increased ORS prescribing at pharmacies by 9 percentage points. Our findings, combined with patient exit surveys suggest that provider perceptions that patients do not want ORS explain 42% of under-prescribing, while stock-outs and financial incentives explain only 6% and 5% respectively.</p>
Diarrhea etiology prediction validation dataset - Bangladesh and Mali
<p>Background: Diarrheal illness is a leading cause of antibiotic use for children in low- and middle-income countries. Determination of diarrhea etiology at the point-of-care without reliance on laboratory testing has the potential to reduce inappropriate antibiotic use.</p> <p>Methods: This prospective observational study aimed to develop and externally validate the accuracy of a mobile software application ("App") for the prediction of viral-only etiology of acute diarrhea in children 0-59 months in Bangladesh and Mali. The App used previously derived and internally validated models using combinations of "patient-intrinsic" information (age, blood in stool, vomiting, breastfeeding status, and mid-upper arm circumference), pre-test odds using location-specific historical prevalence and recent patients, climate, and viral seasonality. Diarrhea etiology was determined with TaqMan Array Card using episode-specific attributable fraction (AFe) >0.5.</p> <p>Results:<b> </b>Of 302 children with acute diarrhea enrolled, 199 had etiologies above the AFe threshold. Viral-only pathogens were detected in 22% of patients in Mali and 63% in Bangladesh. Rotavirus was the most common pathogen detected (16% Mali; 60% Bangladesh). The viral seasonality model had an AUC of 0.754 (0.665-0.843) for the sites combined, with calibration-in-the-large α=-0.393 (-0.455 – -0.331) and calibration slope β=1.287 (1.207 – 1.367). By site, the pre-test odds model performed best in Mali with an AUC of 0.783 (0.705 - 0.86); the viral seasonality model performed best in Bangladesh with AUC 0.710 (0.595 - 0.825).</p> <p>Conclusion: The app accurately identified children with high likelihood of viral-only diarrhea etiology. Further studies to evaluate the app's potential use in diagnostic and antimicrobial stewardship are underway.</p>
An Open-Label Study to Characterize the Incidence and Severity of Diarrhea in Patients With Early-Stage HER2+ Breast Cancer Treated With Neratinib and Loperamide
ClinicalTrials.gov study NCT02400476. IPD Sharing: YES. Countries: 7. Publications: 2.
Diarrhea etiology prediction validation dataset - Bangladesh and Mali
Open the record for dataset details and reuse information.
What drives poor quality of care for child diarrhea? Experimental evidence from India
Open the record for dataset details and reuse information.
NAFLD and diarrhea: a prospective observational study
<p>This is the dataset obtained in the prospective study of the incidence of bile acid diarrhoea in patients with non-alcoholic fatty liver disease NAFLD) conducted at Imperial College London in 2015.</p>
Trial to Understand Efficacy of Colesevelam in Diarrhea Predominant IBS Patients With Bile Acid Malabsorption
ClinicalTrials.gov study NCT03270085. IPD Sharing: NO. Countries: 1. Publications: 1.
Diarrhea Prevention and Prophylaxis With Crofelemer in HER2 Positive Breast Cancer Patients
ClinicalTrials.gov study NCT02910219. IPD Sharing: NO. Countries: 1. Publications: 2.
Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics
ClinicalTrials.gov study NCT03755765. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Rifaximin for Prevention of Travellers' Diarrhea
ClinicalTrials.gov study NCT00742469. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Olorinab in Irritable Bowel Syndrome With Predominant Constipation (IBS-C) and Irritable Bowel Syndrome With Predominant Diarrhea (IBS-D)
ClinicalTrials.gov study NCT04043455. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy, Safety, and Tolerability of Eluxadoline in the Treatment of Participants With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d)
ClinicalTrials.gov study NCT01553747. IPD Sharing: Not stated. Countries: 4. Publications: 2.
A Study to Investigate the Safety and Efficacy of Fidaxomicin (Oral Suspension or Tablets) and Vancomycin (Oral Liquid or Capsules) in Pediatric Subjects With Clostridium Difficile-associated Diarrhea
ClinicalTrials.gov study NCT02218372. IPD Sharing: YES. Countries: 10. Publications: 2.
Effects of Low FODMAP Diet on Colonic Epithelial Physiology in Diarrhea-predominant Irritable Bowel Syndrome
ClinicalTrials.gov study NCT04542018. IPD Sharing: NO. Countries: 1. Publications: 1.
Incidence and Severity of Diarrhea in Patients With HER2 Positive Breast Cancer Treated With Trastuzumab and Neratinib
ClinicalTrials.gov study NCT03094052. IPD Sharing: YES. Countries: 1. Publications: 10.
Lactose-free Milk in Infants With Acute Diarrhea in a Developing Country
ClinicalTrials.gov study NCT02246010. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Meatsafe Food Storage and Diarrhea Prevention Trial in Urban Bangladesh
ClinicalTrials.gov study NCT07332078. IPD Sharing: YES. Countries: 1. Publications: 0.
Fecal Microbiota Transplantation to Treat Recurrent C. Difficile Associated Diarrhea Via Retention Enema or Oral Route
ClinicalTrials.gov study NCT02449174. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Probiotics and Antibiotic Associated Diarrhea in Pediatric Complicated Appendicitis
ClinicalTrials.gov study NCT04529980. IPD Sharing: NO. Countries: 1. Publications: 6.
Efficacy, Safety, and Tolerability of Eluxadoline in the Treatment of Participants With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d)
ClinicalTrials.gov study NCT01553591. IPD Sharing: Not stated. Countries: 3. Publications: 2.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.