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29
datasets available to search
ShareScore release 0.9.0
Dataset results
29 results for “Diosmin”
Rivaroxaban With Diosmin in Long-term Treatment of Deep Vein Thrombosis
ClinicalTrials.gov study NCT03413618. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Simultaneous determination of diosmin and hesperidin in combined pharmaceutical preparation by synchronous fluorescence spectrofluorimetric method
<p>Diosmin (DSM) and hesperidin (HSP) binary mixture was analyzed simultaneously by developing a sensitive, rapid, and simple synchronous spectrofluorimetric method. In methanol at ∆λ of 100 nm, the relative synchronous fluorescence intensities (RSFI) of both medications were measured. It was shown that these intensities were influenced by distinct experimental factors. The optimization and detailed study of these parameters were conducted. For DSM and HSP, respectively, the plots of synchronous fluorescence intensity-concentration were found to be rectilinear across the ranges of 0.5-5.0 µg/mL and 0.2-3.0 µg/mL. For DSM and HSP, respectively, 0.107 µg/mL and 0.048 µg/mL were the detection limits and 0.323 and 0.144 µg/mL were the limits of quantification. The method described in this study was effectively employed to estimate the quantities of both drugs present in commercially available mixed tablets. The results produced using this method were then compared favorably to results obtained using a different method for comparison.</p>
Data from: Diosmin and its glycocalyx restorative and anti-inflammatory effects on injured blood vessels
<p>Endothelium, a crucial homeostatic organ, regulates vascular permeability and tone. Under physiological conditions, endothelial stimulation induces vasodilator endothelial nitric oxide (eNO) release and prevents adhesion molecule accessibility and leukocyte adhesion and migration into vessel walls. Endothelium dysfunction is a principal event in cardiovascular disorders, including atherosclerosis. Hence, current therapies focus on endothelium repair to prevent downstream cardiovascular events. However, minimal attention is given to the restoration of mechanotransducer endothelial glycocalyx (GCX), a negatively charged heterogeneous polysaccharide, which covers and protects endothelial cells. Endothelial GCX shedding plays a role in endothelial dysfunction, increasing vascular permeability and decreasing vessel tone. Diosmin, a flavone glycoside of diosmetin, downregulates adhesive molecule expression, decreases inflammation and capillary permeability, and upregulates eNO expression. Due to these pleiotropic effects of diosmin on the vasculature, a possible unidentified mechanism of action is through GCX restoration. Diosmin effect on GCX and endothelial function were assessed in a partial ligation left carotid artery (LCA) mouse model where the right carotid artery was the control for each mouse. Diosmin (50 mg/kg) was administered daily for 7 days, 48 hours after ligation. Within the ligated mice LCAs, diosmin treatment elevated the activated eNO synthase level, inhibited inflammatory cell uptake, decreased vessel wall thickness, increased vessel diameter, and increased GCX coverage of the vessel wall. ELISA showed a decrease in hyaluronan concentration in plasma samples of diosmin-treated mice, signifying reduced GCX shedding. In summary, diosmin supported endothelial GCX integrity, which preserved endothelial function by attenuating expression of inflammatory factors and restoring vascular tone.</p>
Efficacy and Safety of Diosmin 600mg Versus Placebo on Painful Symptomatology in Patients With Chronic Venous Disease of Lower Limbs
ClinicalTrials.gov study NCT01532882. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Aspiration of Excessive Endometrial Fluid at the Day of Ovum Retrieval Plus Diosmin in (ICSI) Cycles
ClinicalTrials.gov study NCT02158000. IPD Sharing: YES. Countries: 1. Publications: 1.
Comparative Study Between Calcium Gluconate With Diosmin, Cabergoline and Cabergoline With Diosmin
ClinicalTrials.gov study NCT06333691. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Diosmin Versus Cabergoline for Prevention of Ovarian Hyperstimulation Syndrome
ClinicalTrials.gov study NCT02134249. IPD Sharing: YES. Countries: 1. Publications: 1.
Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty
ClinicalTrials.gov study NCT06753448. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Diosmin for Treatment of Delayed-onset Muscle Soreness (DOMS)
ClinicalTrials.gov study NCT06125002. IPD Sharing: NO. Countries: 1. Publications: 6.
Hesperidin and Diosmin Effect on Metabolic Syndrome
ClinicalTrials.gov study NCT05243238. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Simultaneous determination of diosmin and hesperidin in combined pharmaceutical preparation by synchronous fluorescence spectrofluorimetric method
Open the record for dataset details and reuse information.
Data from: Diosmin and its glycocalyx restorative and anti-inflammatory effects on injured blood vessels
Open the record for dataset details and reuse information.
Study to Assess the Efficacy and Safety of Endolex Forte VErsus Diosmin and Hesperidin in Reducing VeNous Insufficiency
ClinicalTrials.gov study NCT02927483. IPD Sharing: YES. Countries: 0. Publications: 7.
Hesperidin and Diosmin for Treatment of COVID-19
ClinicalTrials.gov study NCT04452799. IPD Sharing: NO. Countries: 0. Publications: 1.
A Phase III Clinical Trial Evaluating the Efficacy and Safety of TriThien Duoc Capsules in Grade II Internal Haemorrhoids Patients With Bleeding Compared to Diosmin.
ClinicalTrials.gov study NCT07369635. IPD Sharing: YES. Countries: 1. Publications: 0.
Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency
ClinicalTrials.gov study NCT03471910. IPD Sharing: NO. Countries: 1. Publications: 0.
Oral Tranexamic Acid Versus Diosmin for Treatment of Menorrhagia in Women Using Copper IUD
ClinicalTrials.gov study NCT02616731. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Comparing Diosmin-Hesperidin and Loratadine to Prevent Bone Pain From G-CSF in Patients With Blood Cancers
ClinicalTrials.gov study NCT07300735. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI)
ClinicalTrials.gov study NCT01110512. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Study to Evaluate the Possible Efficacy and Safety of Diosmin and Hesperidin Combined Therapy in Patients With Helicobacter Pylori Infection
ClinicalTrials.gov study NCT06546111. IPD Sharing: NO. Countries: 1. Publications: 0.
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