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41 results for “Dmrt1”
Figure 2 in Identification and expression of Dmrt1 and Sox9 during the gonadal differentiation of Rana chensinensis
Figure 2. Nucleotides and deduced amino acids of rcDmrt1. The DM domain is boxed in shaded rectangles, while the male-specific motifs and P/S-rich element are underlined with a solid and dotted line, respectively. Cysteines and histidines that coordinate Zn2+ are aligned as two intertwined binding sites: site I (circles) and site II (boxes). The stop codon is marked by an asterisk.
Figure 1 in Identification and expression of Dmrt1 and Sox9 during the gonadal differentiation of Rana chensinensis
Figure 1. Images of undifferentiated gonads and differentiated testes and ovaries of R. Chensinensis tadpoles. A, Stage 28; B, stage 46, testis; C, stage 46, ovary. Wd, Wolffian duct; Gmc, gonad-mesonephros complex; Pe, perisome; Ki, kidney; Te, testis; Ov, ovary.
Figure 6. rcDmrt1 and rcSox9 in Identification and expression of Dmrt1 and Sox9 during the gonadal differentiation of Rana chensinensis
Figure 6. rcDmrt1 and rcSox9 expression in various tissues of adult R. chensinensis. Upper two panels, RT-PCR using rcDmrt1 and rcSox9 gene-specific primers, respectively; lower panel, control RT-PCR using rpl8 gene-specific primers.
Figure 4 in Identification and expression of Dmrt1 and Sox9 during the gonadal differentiation of Rana chensinensis
Figure 4. The neighbor-joining phylogenetic trees of Dmrt1 and Sox9. Phylogenetic tree was constructed on the basis of alignment of the amino acid sequences of Dmrt1 and Sox9 homologs, showing the evolutionary relationship of rcDmrt1 (A) and rcSox9 (B) with other species of the Dmrt1 and Sox9 family. Numbers at branch nodes are percentages of bootstrap confidence values derived from 2000 replications. GenBank Accession Nos. of various species are shown in Table 2.
Figure 3 in Identification and expression of Dmrt1 and Sox9 during the gonadal differentiation of Rana chensinensis
Figure 3. Nucleotides and deduced amino acids of rcSox9. The HMG-box domain is boxed in shaded rectangles, while the Sox-N domain and PQA-rich element are underlined with a solid and dotted line, respectively. The stop codon is marked by an asterisk.
Data from: Dmrt1 polymorphism covaries with sex-determination patterns in Rana temporaria
Patterns of sex-chromosome differentiation and gonadal development have been shown to vary among populations of Rana temporaria along a latitudinal transect in Sweden. Frogs from the northern-boreal population of Ammarnäs displayed well-differentiated X and Y haplotypes, early gonadal differentiation, and a perfect match between phenotypic and genotypic sex. In contrast, no differentiated Y haplotypes could be detected in the southern population of Tvedöra, where juveniles furthermore showed delayed gonadal differentiation. Here, we show that Dmrt1, a gene that plays a key role in sex determination and sexual development across all metazoans, displays significant sex differentiation in Tvedöra, with a Y-specific haplotype distinct from Ammarnäs. The differential segment is not only much shorter in Tvedöra than in Ammarnäs, it is also less differentiated and associates with both delayed gonadal differentiation and imperfect match between phenotypic and genotypic sex. Whereas Tvedöra juveniles with a local Y haplotype tend to ultimately develop as males, those without it may nevertheless become functional XX males, but with strongly female-biased progeny. Our findings suggest that the variance in patterns of sex determination documented in common frogs might result from a genetic polymorphism within a small genomic region that contains Dmrt1. They also substantiate the view that recurrent convergences of sex determination toward a limited set of chromosome pairs may result from the co-option of small genomic regions that harbor key genes from the sex-determination pathway.
Data from: Dmrt1 polymorphism and sex-chromosome differentiation in Rana temporaria
Sex-determination mechanisms vary both within and among populations of common frogs, opening opportunities to investigate the molecular pathways and ultimate causes shaping their evolution. We investigated the association between sex-chromosome differentiation (as assayed from microsatellites) and polymorphism at the candidate sex-determining gene Dmrt1 in two Alpine populations. Both populations harboured a diversity of X-linked and Y-linked Dmrt1 haplotypes. Some males had fixed male-specific alleles at all markers ("differentiated" Y chromosomes), others only at Dmrt1 ("proto-" Y chromosomes), while still others were genetically indistinguishable from females (undifferentiated X chromosomes). Besides these XX males, we also found rare XY females. The several Dmrt1 Y haplotypes differed in the probability of association with a differentiated Y chromosome, which we interpret as a result of differences in the masculinizing effects of alleles at the sex-determining locus. From our results, the polymorphism in sex-chromosome differentiation and its association with Dmrt1, previously inferred from Swedish populations, are not just idiosyncratic features of peripheral populations, but also characterize highly diverged populations in the central range. This implies that an apparently unstable pattern has been maintained over long evolutionary times.
Data from: Dmrt1 polymorphism covaries with sex-determination patterns in Rana temporaria
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Data from: Dmrt1 polymorphism and sex-chromosome differentiation in Rana temporaria
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Figure 5 in Identification and expression of Dmrt1 and Sox9 during the gonadal differentiation of Rana chensinensis
Figure 5. Expression of rcDmrt1 and rcSox9 in GMC/gonads of R. chensinensis tadpoles at stages 26–46. M, Male; F, female.
Data from: Trans-species variation in Dmrt1 is associated with sex determination in four European tree-frog species
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Sexual cell fate reprogramming in the ovary by DMRT1
GEO Series GSE64960. Mus musculus. 144 samples. Type: Expression profiling by high throughput sequencing.
Regulation of human germline commitment by DMRT1 [scRNA-Seq]
GEO Series GSE223033. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Distruption of DMRT1 induces feminization in Chicken
GEO Series GSE150339. Gallus gallus. 24 samples. Type: Expression profiling by high throughput sequencing.
Regulation of human germline commitment by DMRT1
GEO Series GSE223036. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Other; Genome binding/occupancy profiling by high throughput sequencing.
The conserved sex regulator/pioneer factor DMRT1 recruits SOX9 in sexual cell fate reprogramming
GEO Series GSE154484. Mus musculus. 119 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Regulation of human germline commitment by DMRT1 [CUT&RUN]
GEO Series GSE223035. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dmrt1 (doublesex and mab-3 related transcription factor 1) knockout expression analyses in E13.5 testes in S6 background
GEO Series GSE18396. Mus musculus. 6 samples. Type: Expression profiling by array.
Conditional Dmrt1 knockout gene expression (phase 8)
GEO Series GSE22508. Mus musculus. 4 samples. Type: Expression profiling by array.
Regulation of human germline commitment by DMRT1 [Bisulfite-Seq]
GEO Series GSE223034. Homo sapiens. 12 samples. Type: Methylation profiling by high throughput sequencing.
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