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41 results for “Dose distribution”
Repository of posterior distributions from Bayesian benchmark dose analysis
<p>This repository contains posterior distributions for all model parameters obtained from analysis of continuous dose-response studies.</p>
CyberKnife Radiosurgery for Organ-Confined Prostate Cancer: Homogenous Dose Distribution
ClinicalTrials.gov study NCT00643994. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Probabilistic interfractional motion carbon ion radiation therapy dose distribution for prostate cancer shows rectum sparing with moderate target coverage degradation
Purpose: This observational study investigates the influence of interfractional motion on clinical target volume (CTV) coverage, planning target volume (PTV) margins, and rectum tissue sparing in carbon ion radiation therapy (CIRT). It reports dose coverage to target structures and organs at risk in the presence of interfractional motion, investigates rectal tissue sparing, and provides recommendations for further lowering the rate of toxicity. We also propose probabilistic DVH for consideration in treatment planning to represent probable dose to the clinic's patient population. Methods: At Gunma University Hospital intensity-modulated x-ray therapy (IMXT, aka IMRT) prostate cancer patients are positioned on a table which is shifted twice based on cone-beam computed tomography (CBCT) to align bones and then align prostate tissue to isocenter. These shifts thereby contain interfractional motion. 1306 such tableshifts from 85 patients were collected. Normal probability distributions were fit to the difference between bone-matching and prostate-matching CBCT-to-planning CT tableshifts (i.e. interfractional motion). Between 2011 and 2016 CIRT prostate patients were treated with PTV1 and PTV2 margins as follows: PTV1 extends the prostate contour by 10/10, 5/10, 6/6 mm in the right/left, posterior/anterior, and superior/inferior directions, respectively, and the proximal seminal vesicles contour by 5 mm superiorly and inferiorly, 3 mm right and left. PTV2 reduces PTV1 posteriorly along a straight line to exclude the rectum and reduces the superior and inferior margins by 6 mm. From those treated with these margins, 40 patients' beam data were selected to create probable interfractional motion: The previously fit normal probability distributions were randomly sampled 2000 times per patient and beams shifted to simulate this motion. These shifted dose distributions were scaled down proportionately in magnitude and summed to obtain probable blurred dose distributions. Results: Probable dose to rectum is substantially less than planned for doses higher than 10 Gy(RBE). Absolute DVH show that mean clinical target volumes are about 138-670 cm3 smaller for a given probable dose than planned doses higher than 57 Gy(RBE) after accounting for standard error. Cumulative DVH show mean CTV fraction receiving a given probable dose is less than the mean fraction receiving the corresponding planned dose for doses larger than 52 Gy(RBE), up to 19% less at 57.4 Gy(RBE). Our PTV1 margins generally cover 95% of interfractional motion but seminal vesicles and inferior prostate receive less dose than planned due to insufficient PTV2 margins. Conclusion: Assuming rigidly shifting interfractional motion around the prostate region and neglecting minor changes in soft tissue stopping power, interfractional motion resulted in underdosing or tissue sparing in all cases. Given our low rates of relapse and recurrence, it appears less curative dose is needed than previously thought or else the target may be smaller than previously thought. In-room CT may be useful to lower dose, shrink target margins, conduct PET auto-activation dose verification studies and account for interfractional motion.
A Phase 1 (Ph1), Single Dose (SD), GSK961081 Absorption, Distribution, Metabolism, and Excretion (ADME) Study in Healthy Subjects
ClinicalTrials.gov study NCT02663089. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An Absorption, Distribution, Metabolism and Excretion (ADME) Study of Single Oral Dose [14C] GSK2118436 in Subjects With BRAF Mutant Solid Tumors
ClinicalTrials.gov study NCT01262963. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study Evaluating Absorption, Distribution, Metabolism and Excretion (ADME) of Single Dose [14C] Selumetinib in Volunteers
ClinicalTrials.gov study NCT01931761. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Investigate the Effect of Itraconazole on the Way the Body Absorbs, Distributes, and Gets Rid of ACT-1004-1239 Given as a Single Dose of 10 mg to Healthy Male Subjects
ClinicalTrials.gov study NCT05549531. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Probabilistic interfractional motion carbon ion radiation therapy dose distribution for prostate cancer shows rectum sparing with moderate target coverage degradation
Open the record for dataset details and reuse information.
Monte Carlo simulated absorbed dose distributions inside BluePhantom2 water phantom with PMMA walls for 220 MeV pencil proton beam
<p>This dataset consists of Monte Carlo simulated dose distributions inside 65x62x55 cm<sup>3</sup> BluePhantom<sup>2</sup> water phantom with PMMA walls for 220 MeV pencil proton beam. Contribution to the absorbed dose is provided separately for protons, photons+electron, and neutrons. Neutron and the total equivalent dose is also provided.</p> <p>Monte Carlo simulations used the MCNP6.2 code. Libraries used: HLIB=70h NLIB=00c PLIB=14p ELIB=03e PNLIB=70u. Particle cut-off energies used: CUT:P 4 keV, CUT:H 300 keV, CUT:E 2 keV, CUT:T,A,D,S,|,# j 1 MeV. Primary beam: monoenergetic 220 MeV proton pencil beam, beam profile full-width at half maximum = 1.5 cm.</p> <p>This is the result of the EMPIR 18HLT04 UHDpulse project.<br> </p>
A Pharmacodynamic Study to Evaluate Neutrophil Distribution Kinetics and Function Following Single-Dose RoActemra/Actemra (Tocilizumab) in Healthy Volunteers
ClinicalTrials.gov study NCT01991990. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study Evaluating Absorption, Distribution, Metabolism and Excretion (ADME) of Single Dose [14C]-BI 207127 in Healthy Male Volunteers
ClinicalTrials.gov study NCT01605461. IPD Sharing: Not stated. Countries: 1. Publications: 0.
iFAAM: The Impact of Proton-pump Inhibitors (Antacids) on Threshold Dose Distributions
ClinicalTrials.gov study NCT02552537. IPD Sharing: Not stated. Countries: 2. Publications: 0.
A Study to Evaluate the Distribution of Botulinum Neurotoxin Type A Administered as Intradermal Injections, Comparing Different Doses, Concentrations, and Delivery Methods
ClinicalTrials.gov study NCT05585398. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study To Assess Distribution Of RO7248824 In The Central Nervous System Following Single Intrathecal Doses Of [89zr] Labeled RO7248824 In Healthy Male Participants
ClinicalTrials.gov study NCT04863794. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study on the Safety of BAY 63-2521, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given as a Single Oral Dose of 1 mg Tablet in Participants With Renal I
ClinicalTrials.gov study NCT04364464. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Study to Evaluate the Absorption, Distribution, Metabolism, Excretion and Absolute Bioavailability of AG-348 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C]AG-34
ClinicalTrials.gov study NCT03703505. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study Evaluating Absorption, Distribution, Metabolism and Excretion (ADME) of Single Dose [14C] AZD2423 in Volunteers
ClinicalTrials.gov study NCT01223014. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Assess the Effect of Race on How a Single Dose of ASP3652 is Taken up, Metabolized and Distributed Through the Bodies of Young, Healthy Male and Female Subjects, and Its Safety and Tolerabi
ClinicalTrials.gov study NCT01958047. IPD Sharing: Not stated. Countries: 1. Publications: 0.
An Open Label Multicentre Study to Determine the Dose Distribution of Paliperidone ER in Patients With Schizophrenia
ClinicalTrials.gov study NCT00473434. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Single Dose Absorption, Distribution, Metabolism, and Excretion Study of [14C]-CORT113176 in Healthy Male Participants
ClinicalTrials.gov study NCT04990310. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.