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483
datasets available to search
ShareScore release 0.9.0
Dataset results
483 results for “Drug therapy”
The repurposing of tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug resistant Shigella spp.
<p><strong>dataset for The repurposing of tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug resistant <em>Shigella</em> spp.</strong></p> <p>Elena Fernández Alvaro <sup>1*</sup>, Phat Voong Vinh <sup>2</sup>, Cristina de Cozar <sup>1</sup>, David Wille <sup>1</sup>, Beatriz Urones <sup>1</sup>,</p> <p>Alan Price <sup>1</sup>, Nhu Tran Do Hoang <sup>2</sup>, Tuyen Ha Thanh <sup>2</sup>, Molly McCloskey <sup>3</sup>, Shareef Shaheen<sup> 3</sup>, Denise Dayao<sup> 4</sup>, Jaime de Mercado <sup>1</sup>, Pablo Castañeda <sup>1</sup>, Adolfo García-Perez <sup>1</sup>, Benson Singa <sup>5</sup>, Patricia Pavlinac <sup>6</sup>,</p> <p>Judd Walson<sup>3</sup>, Maria Santos Martínez-Martínez <sup>1</sup>, Samuel L.M. Arnold <sup>3</sup>, Tzipori Saul <sup>4</sup>, Lluis Ballell <sup>1#</sup>,</p> <p>and Stephen Baker <sup>7,8*</sup></p> <p> </p>
Special Drug Use Surveillance of Vonoprazan for "Maintenance Therapy of Reflux Esophagitis: Long-term Use"
ClinicalTrials.gov study NCT03214081. IPD Sharing: YES. Countries: 1. Publications: 0.
Preclinical developent of an innovative drug candidate in systemic fungal therapy
<p>The dataset documents results of studies in the area of drug development co-founded by the National Centre for Research and Development <strong>(Poland), grant number </strong> <strong>POIR.01.01.01-00-1990/15-00, tytuł: <em>Badania przedkliniczne i kliniczne kandydata na innowacyjny lek w terapii inwazyjnych grzybic układowych.</em></strong></p> <p>The objective of the project was to conduct preclinical and potantially Phase I clinical studies of a new compound to develop an innovative drug for treatment of invasive systemic mycoses. The compound will be selected from the group of innovative Amphotericin B derivatives developed during the BLIRT project co-funded under the 1.4–4.1 Innovative Economy Operational Programme, which have shown significant improvement of selective toxicity compared to the native drug. Moreover, the solubility of the compounds has been ensured, which enables their bioavailability. The innovative derivatives have characteristics of an ideal antifungal drug – fungicidal activity, low toxicity, aqueous solubility, no induction of resistance, activity against MDR strains, and a broad antifungal<br> spectrum. Their therapeutic efficacy has been preliminarily proven on a model of systemic candidiasis in mice.</p> <p>The project was unsuccesful due to not enough competitive advantages of developed candidates regarding their antifungla efficacy and safety which did not justify further investments of both public and private funds.</p> <p>The dataset contain reports from the conducted studies performed both in house but also in well established CROs. It cover the chemical sythesis of compounds, preparation of their liposomal formulations and preclinical studies in vitro and in vivo performed until the project was stopped, due to not achieving the set development milestone (preclinical stage). It is widely communicatd to the scientific community so that future projects could benefit form the generated know-how.</p> <p> </p> <p> </p>
Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer
ClinicalTrials.gov study NCT04406857. IPD Sharing: YES. Countries: 1. Publications: 1.
Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia
ClinicalTrials.gov study NCT00001521. IPD Sharing: NO. Countries: 1. Publications: 1.
Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers
ClinicalTrials.gov study NCT02466971. IPD Sharing: Not stated. Countries: 3. Publications: 2.
To Evaluate The Effect Of SAR153191 (REGN88) Added To Other RA Drugs In Patients With RA Who Are Not Responding To Or Intolerant Of Anti-TNF Therapy (SARIL-RA-TARGET)
ClinicalTrials.gov study NCT01709578. IPD Sharing: Not stated. Countries: 30. Publications: 10.
Ablation vs Drug Therapy for Atrial Fibrillation - Pilot Trial
ClinicalTrials.gov study NCT00578617. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Gl
ClinicalTrials.gov study NCT04396860. IPD Sharing: YES. Countries: 1. Publications: 2.
Drug Therapy for Generalized Anxiety Disorder Among the Elderly
ClinicalTrials.gov study NCT00105586. IPD Sharing: YES. Countries: 1. Publications: 4.
An Open-Label Phase 1/2 Study to Assess the Safety, Efficacy and Dose of Study Drug UX003 Recombinant Human Beta-glucuronidase (rhGUS) Enzyme Replacement Therapy in Patients With Mucopolysaccharidosis
ClinicalTrials.gov study NCT01856218. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Drug and Talk Therapy for Fibromyalgia
ClinicalTrials.gov study NCT01038323. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Oxytocin and Cognitive Behavioral Therapy in Drug Dependence
ClinicalTrials.gov study NCT00975416. IPD Sharing: Not stated. Countries: 1. Publications: 3.
AV Node Ablation and Pacemaker Therapy Compared to Drug Therapy for Atrial Fibrillation - Pilot Study
ClinicalTrials.gov study NCT00589303. IPD Sharing: Not stated. Countries: 2. Publications: 6.
Quantifying Drug Adherence and Drug Exposure to Antiretroviral Therapy
ClinicalTrials.gov study NCT02012621. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Patient Reported Outcomes inVestigation Following Initiation of Drug Therapy With Entresto (Sacubitril/Valsartan) in Heart Failure
ClinicalTrials.gov study NCT03387163. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Brief Strategic Family Therapy for Adolescent Drug Abusers
ClinicalTrials.gov study NCT00095303. IPD Sharing: Not stated. Countries: 2. Publications: 8.
Testing the Addition of a New Immunotherapy Drug, Atezolizumab (MPDL3280A), to the Usual Chemoradiation (CRT) Therapy Treatment for Limited Stage Small Cell Lung Cancer (LS-SCLC)
ClinicalTrials.gov study NCT03811002. IPD Sharing: YES. Countries: 2. Publications: 2.
Catheter Ablation vs Anti-arrhythmic Drug Therapy for Atrial Fibrillation Trial
ClinicalTrials.gov study NCT00911508. IPD Sharing: Not stated. Countries: 10. Publications: 19.
Combination Drug-Therapy for Patients With Untreated Obstructive Sleep Apnea
ClinicalTrials.gov study NCT04639193. IPD Sharing: NO. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.