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108 results for “ECM”
Dataset related to article "Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin"
<p>This record contains raw data related to article "Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin"</p> <p>Abstract</p> <p>Control of synapse number and function in the developing central nervous system is critical to the formation of neural circuits. Astrocytes play a key role in this process by releasing factors that promote the formation of excitatory synapses. Astrocyte-secreted thrombospondins (TSPs) induce the formation of structural synapses, which however remain post-synaptically silent, suggesting that completion of early synaptogenesis may require a two-step mechanism. Here, we show that the humoral innate immune molecule Pentraxin 3 (PTX3) is expressed in the developing rodent brain. PTX3 plays a key role in promoting functionally-active CNS synapses, by increasing the surface levels and synaptic clustering of AMPA glutamate receptors. This process involves tumor necrosis factor-induced protein 6 (TSG6), remodeling of the perineuronal network, and a β1-integrin/ERK pathway. Furthermore, PTX3 activity is regulated by TSP1, which directly interacts with the N-terminal region of PTX3. These data unveil a fundamental role of PTX3 in promoting the first wave of synaptogenesis, and show that interplay of TSP1 and PTX3 sets the proper balance between synaptic growth and synapse function in the developing brain.</p> <p> </p>
Data rom: Stiffness anisotropy coordinates supracellular contractility driving long-range myotube-ECM alignment
<p>The ability of cells to organize into tissues with proper structure and function requires the effective coordination of proliferation, migration, polarization, and differentiation across length scales. Skeletal muscle is innately anisotropic; however, few biomaterials can emulate mechanical anisotropy to determine its influence on tissue patterning without introducing confounding topography. Here, we demonstrate that substrate stiffness anisotropy coordinates contractility-driven collective cellular dynamics resulting in C2C12 myotube alignment over millimeter-scale distances. When cultured on mechanically anisotropic liquid crystalline polymer networks (LCNs) lacking topography, C2C12 myoblasts collectively polarize in the stiffest direction. Cellular coordination is amplified through reciprocal cell-ECM dynamics that emerge during fusion, driving global myotube-ECM ordering. Conversely, myotube alignment was restricted to small local domains with no directional preference on mechanically isotropic LCNs of the same chemical formulation. These findings provide valuable insights for designing biomaterials that mimic anisotropic microenvironments and underscore the significance of stiffness anisotropy in orchestrating tissue morphogenesis.</p>
A Post Market Study on the Use of Cormatrix® Cangaroo ECM® (Extracellular Matrix) Envelope
ClinicalTrials.gov study NCT02530970. IPD Sharing: Not stated. Countries: 1. Publications: 1.
TECR & ECM Placement for Esophageal High Grade Dysplasia
ClinicalTrials.gov study NCT02396745. IPD Sharing: NO. Countries: 1. Publications: 16.
Obtain Additional Information on Use of CorMatrix ECM (Extracellular Matrix)
ClinicalTrials.gov study NCT02073331. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data rom: Stiffness anisotropy coordinates supracellular contractility driving long-range myotube-ECM alignment
Open the record for dataset details and reuse information.
Microscopy images from: A cadherin-integrin-ECM code for presomitic mesoderm fluidity
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Progressive virtual transverse section through a porcine MV leaflet sample to demonstrate the visualization of the heterogeneous organization of the ECM fibers using Hf-WD 1:2 POM-based cryo-CECT
<p>The atrial side is at the top and the ventricular side at the bottom. At the beginning of the video, the yellow and blue arrows indicate the presence of adipocytes and blood vessels, respectively.</p>
Investigation of A-ECM for the Correction of Soft Tissue Defects
ClinicalTrials.gov study NCT01992315. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Epicardial Infarct Repair Using CorMatrix®-ECM: Clinical Feasibility Study
ClinicalTrials.gov study NCT02887768. IPD Sharing: YES. Countries: 1. Publications: 2.
Hyaluronic acid-binding, anionic, nanoparticles inhibit ECM degradation and restore compressive strength in aggrecan-depleted articular cartilage explants
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CorMatrix ECM for Carotid Repair Following Endarterectomy Registry
ClinicalTrials.gov study NCT01569594. IPD Sharing: Not stated. Countries: 1. Publications: 0.
CorMatrix ECM Study: To Identify Inflammatory Markers Following CABG With/Without ECM
ClinicalTrials.gov study NCT01535807. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer
GEO Series GSE297099. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing.
Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice [mRNA-seq]
GEO Series GSE241577. Mus musculus. 46 samples. Type: Expression profiling by high throughput sequencing.
Fibroblast starvation activates ECM remodeling gene transcription and putative enhancers despite inducing quiescence [bruseq]
GEO Series GSE272506. Homo sapiens. 6 samples. Type: Other.
A human pancreatic ECM hydrogel optimized for 3-D modeling of the islet microenvironment
GEO Series GSE166505. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
D2.0R mouse breast cancer cells cultured on stiff or soft ECM hydrogels
GEO Series GSE189803. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through in-situ delivery of nucleus pulposus progenitor cell-derived exosomes [RNA-Seq]
GEO Series GSE290271. Rattus norvegicus. 12 samples. Type: Expression profiling by high throughput sequencing.
ECM-dependent gene expression in normal and tumor-derived mammary organoids
GEO Series GSE39173. Mus musculus. 13 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.