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44 results for “EPILEPSY SURGERY”
Intracranial EEG Structure-Function Coupling and Seizure Outcomes After Epilepsy Surgery
<p>iEEGnetworksFC: Functional Connectivity Networks</p> <p>iEEGnetworkSCPre: Structural Connectivity Networks before surgery</p> <p>iEEGnetworkSCPost: Structural Connectivity Networks expected after surgery</p> <p>iEEGnetworkSCPre5mm: Structural Connectivity Networks before surgery with alternate ROI size of 5mm at each contact</p> <p> </p>
The Prevalence and Risk Factors of Coagulopathy in Pediatric Epilepsy Surgery Patients
ClinicalTrials.gov study NCT05675254. IPD Sharing: NO. Countries: 1. Publications: 1.
Structural brain network abnormalities and the probability of seizure recurrence after epilepsy surgery
<p>Supplementary code and data for "Structural brain network abnormalities and the probability of seizure recurrence after epilepsy surgery<strong>" </strong></p> <p>https://doi.org/10.1212/WNL.0000000000011315</p>
Simulation results and lambda value data for structural connectome based simulations of temporal lobe epilepsy surgery.
<p>This data file contains a number of matlab matrices holding the results of simulations carried out using structural connectome data from healthy individuals and individuals with a diagnosis of temporal lobe epilepsy (TLE). The results are in the form of either time values, representing the time at which brain regions in the simulations 'escaped' into a seizure state, or corresponding node labels which represent the region that escaped at that time. Simulations were stopped after the first three nodes escaped, and then repeated over 100 iterations. There were 39 controls and 22 left TLE patients. Simulations were also carried out for altered structural connectomes simulating surgery influence on the time taken for nodes to escape. Clinical resection (clinres), subject-specific resections (subspecres) or random resections (ranres). 'Lmdas' shows the deviation from the control average of surface areas for each region in each subject, normalised to lie between 0 and 1. 'Names' is a cell array containing the node labels for the 82 regions.</p>
Psychological and Psychiatric Assessment in Patients Eligible for Epilepsy Surgery
ClinicalTrials.gov study NCT06792383. IPD Sharing: NO. Countries: 1. Publications: 9.
Readiness Brain Operation Optimization Training (ReBOOT) for Epilepsy Surgery
ClinicalTrials.gov study NCT05992402. IPD Sharing: NO. Countries: 1. Publications: 15.
The Impact of Epilepsy Surgery on Dream Content
ClinicalTrials.gov study NCT02731443. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Radiosurgery or Open Surgery for Epilepsy Trial
ClinicalTrials.gov study NCT00860145. IPD Sharing: YES. Countries: 2. Publications: 1.
Study of Specimens Obtained During Epilepsy Surgery
ClinicalTrials.gov study NCT00025714. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery
ClinicalTrials.gov study NCT04344626. IPD Sharing: NO. Countries: 2. Publications: 16.
Surgery as a Treatment for Medically Intractable Epilepsy
ClinicalTrials.gov study NCT01273129. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
The Effectiveness and Safety of Resective Epilepsy Surgery for TRE
ClinicalTrials.gov study NCT04198181. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
A New Method for Delineation of Epileptic Brian Tissue During Epilepsy Surgery (The HFO Study)
ClinicalTrials.gov study NCT02207673. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Structural brain network abnormalities and the probability of seizure recurrence after epilepsy surgery: supplementary material
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Data from: Long-term employment outcomes after epilepsy surgery in childhood
Objective: To analyse long-term employment outcomes in a population-based cohort of adults who underwent epilepsy surgery in childhood or adolescence and to compare the results to general population reference data. Methods: Prospective data on epilepsy surgery procedures performed on patients <19 years of age between 1995 and 2012 were extracted from the Swedish National Epilepsy Surgery Register. Five-, 10-, 15- and 20-year follow-up data were analysed. Patients aged ≥19 years at follow-up were eligible for inclusion. Educational attainment and employment status were analysed in relation to seizure outcome. Education and employment outcomes of seizure-free patients with a preoperative IQ of ≥70 were compared to general population reference data. Results: A total of 203 patients were included. The mean age at surgery was 13.6 years and 66% had IQ≥70. Of these, a majority had attained at least high school education five years after surgery. Employment rates were 44%, 69%, 71% and 77% at the 5-, 10-, 15- and 20-year follow-ups, respectively. Seizure-free patients were significantly more likely to work full-time. Educational attainment and rates of full-time employment of seizure-free patients were similar to the general population. A majority of patients with IQ<70 had attended special education and were reliant on social benefits. Conclusion: Long-term overall employment rates were higher compared to most previous studies on surgery in adults. Seizure-free patients with a preoperative IQ≥70 showed rates of full-time employment similar to the general population. Further research is needed to determine whether this also applies for occupational complexity and wages.
Seizure outcome of pediatric epilepsy surgery: systematic review and meta-analyses
<p><b>Objective:</b> This systematic review and meta-analyses assessed seizure outcome following pediatric epilepsy surgery.</p> <p><b>Methods: </b>MEDLINE, Embase and Cochrane were searched for pediatric epilepsy surgery original research from 1990 to 2017. The outcome was seizure freedom at 12 months or longer follow-up. Using random effects models, the effect sizes for controlled studies, uncontrolled studies on surgery locations (temporal lobe [TL], extra-temporal lobe [ETL] or hemispheric surgery), pathologies, non-lesional epilepsy and incomplete resection were estimated. Meta-regression assessed the relationship between age at surgery, age at seizure onset and seizure outcome. Random-effects network meta-analysis was conducted for surgery locations.</p> <p><b>Results:</b> 258 studies were included. Surgery achieved higher seizure freedom than medical therapy (OR=6.49 [95%CI: 2.87, 14.70], p<0.001). Seizure freedom declined over time after surgery, from 64.8% (95%CI: 51.2%, 76.4%; p=0.034) at 1 year, to 60.3% (95%CI: 52.9%, 67.4%; p=0.007) at 5 years, and 39.7% (95%CI: 28.4%, 52.2%, p=0.106) at 10 years. Seizure freedom was (i) highest for hemispheric surgery, followed by TL, and ETL surgery; and (ii) highest for tumor, and lower for malformations of cortical development. Seizure freedom was lower for non-lesional than lesional epilepsy (OR=0.54 [95%CI: 0.34, 0.88], p=0.013), and incomplete than complete resection (OR=0.13 [95%CI: 0.08, 0.21], p<0.001). Age at surgery and age at seizure onset were associated with seizure freedom for mixed pathologies and surgery locations, and TL surgery.</p> <p><b>Conclusion:</b> Epilepsy surgery was more effective than medical therapy to control seizures. Understanding seizure outcomes of different surgery locations, pathologies, non-lesional epilepsy and incomplete resection will assist with pre-surgical counselling.</p>
The cost effectiveness of surgery for drug resistant temporal lobe epilepsy in the US
<p><strong>Objective:</strong> Surgery is an effective but costly treatment for many patients with drug resistant temporal lobe epilepsy (DR-TLE). We aim to evaluate whether, in the United States, 1) surgery is cost-effective compared to medical management for patients deemed surgical candidates, 2) surgical evaluation is cost-effective for DR-TLE patients in general.</p> <p><strong>Methods:</strong> We use a semi-Markov model to assess the cost-effectiveness of surgery and surgical evaluation over a lifetime horizon. We use 2<sup>nd</sup> order Monte Carlo simulations to conduct probabilistic sensitivity analyses to estimate variation in model output. We adopt both healthcare and societal perspectives, including direct healthcare costs (e.g. surgery, AEDs) and indirect costs (e.g. lost earnings by patients and care providers.) We compare incremental cost-effectiveness ratio (ICER) to societal willingness-to-pay (~$100,000 per Quality Adjusted Life Year) to determine whether surgery is cost-effective.</p> <p><strong>Results:</strong> Epilepsy surgery is cost effective compared to medical management in surgically eligible patients by virtue of being cost saving ($328K vs. 423K) and more effective (16.6 QALY vs. 13.6 QALY) than medical management in the long run. Surgical evaluation is cost-effective in DR-TLE patients even if the probability of being deemed a surgical candidate is only 5%. From a societal perspective, surgery becomes cost effective within 3 years and 89% of simulations favor surgery over the lifetime horizon.</p> <p><strong>Conclusion:</strong> For surgically eligible DR-TLE patients, surgery is cost-effective. For DR-TLE patients in general, referral for surgical evaluation (and possible subsequent surgery) is cost-effective. DR-TLE patients should be referred for surgical evaluation without hesitation on cost-effectiveness grounds.</p>
High Frequency Oscillation in Pediatric Epilepsy Surgery
ClinicalTrials.gov study NCT03790280. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Seizure outcome of pediatric epilepsy surgery: systematic review and meta-analyses
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Data from: Epilepsy duration and seizure outcome in epilepsy surgery: a systematic review and meta-analysis
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