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Dataset results
22 results for “ESCRT”
Data from: ESCRT-III-dependent adhesive and mechanical changes are triggered by a mechanism detecting alteration of Septate Junction integrity in Drosophila epithelial cells
<p><span>Barrier functions of proliferative epithelia are constantly challenged by mechanical and chemical constraints. How epithelia respond to and cope with disturbances of barrier functions to allow tissue integrity maintenance is poorly characterized. Cellular junctions play an important role in this process and intracellular traffic contribute to their homeostasis. Here, we reveal that, in <em>Drosophila</em> pupal <em>notum</em>, alteration of the bi- or tricellular septate junctions (SJs) triggers a mechanism with two prominent outcomes. On one hand, there is an increase in the levels of E-cadherin, F-Actin and non-muscle Myosin II in the plane of adherens junctions. On </span><span>the other hand, β-integrin/Vinculin-positive cell contacts are reinforced along the lateral and basal membranes. We found that the weakening of SJ integrity, caused by the depletion of bi- or tricellular SJ components, alters ESCRT-III/Vps32/Shrub distribution, reduces degradation, and instead favours recycling of SJ components, an effect that extends to other recycled transmembrane protein cargoes including Crumbs, its effector β-Heavy Spectrin</span><span> Karst, and </span><span>β-integrin</span><span>. We propose a mechanism by which epithelial cells, upon sensing alterations of the septate junction</span><span>,</span><span> reroute the function of Shrub to adjust the balance of degradation/recycling of junctional cargoes and thereby compensate for barrier junction defects to maintain epithelial integrity.</span></p>
Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters, data part 1
<p>Part one of the data used for the generation of the article <em>Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters.</em></p>
Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters, data part 2
<p>Part 2 of data for the article <em>Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters.</em></p>
Secretome dataset for: The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence
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Proteomic dataset for: The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence
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Data from: ESCRT-III-dependent adhesive and mechanical changes are triggered by a mechanism detecting alteration of Septate Junction integrity in Drosophila epithelial cells
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Transcriptome dataset for: The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence
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Data: An ESCRT-III polymerization sequence drives membrane deformation and fission
<p>Raw data to "an ESCRT-III polymerization sequence drives membrane deformation and fission"</p>
Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters, data part 6
<p>Part 6 of data for the article Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters.</p>
Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters, data part 4
<p>Part 4 of data for the article Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters.</p>
Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters, data part 3
<p>Part 3 of data for the article <em>Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters.</em></p>
Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters, data part 5
<p>Part 5 of data for the article Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters.</p>
Data from: Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding
The ESCRT machinery mediates reverse membrane scission. By quantitative fluorescence lattice light-sheet microscopy, we have shown that ESCRT-III subunits polymerize rapidly on yeast endosomes, together with the recruitment of at least two Vps4 hexamers. During their 3-45 second lifetimes, the ESCRT-III assemblies accumulated 75-200 Snf7 and 15-50 Vps24 molecules. Productive budding events required at least two additional Vps4 hexamers. Membrane budding was associated with continuous, stochastic exchange of Vps4 and ESCRT-III components, rather than steady growth of fixed assemblies, and depended on Vps4 ATPase activity. An all-or-none step led to final release of ESCRT-III and Vps4. Tomographic electron microscopy demonstrated that acute disruption of Vps4 recruitment stalled membrane budding. We propose a model in which multiple Vps4 hexamers (four or more) draw together several ESCRT-III filaments. This process induces cargo crowding and inward membrane buckling, followed by constriction of the nascent bud neck and ultimately ILV generation by vesicle fission.
Vps60 initiates alternative ESCRT-III filaments
<p>Source data for :"Vps60 initiates alternative ESCRT-III filaments"</p>
Data from: Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding
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The ESCRT-III protein CHMP1A mediates secretion of sonic hedgehog on a novel class of extracellular vesicles
GEO Series GSE115867. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
PTPN23-dependent ESCRT machinery functions as a cell death checkpoint in restraining multiple cell death pathways
GEO Series GSE272123. Homo sapiens. 76 samples. Type: Expression profiling by high throughput sequencing.
ESCRT-I controls lysosomal membrane protein homeostasis and restricts MCOLN1-dependent TFEB/TFE3 signaling.
GEO Series GSE178665. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
USP8 coordinates ESCRT-mediated membrane repair, xenophagy, and oxidative stress responses during Mycobacterium tuberculosis infection
GEO Series GSE240372. Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing.
Components of the ESCRT machinery act downstream of MLKL to regulate necroptotic cell death and its consequences
GEO Series GSE85660. Mus musculus. 9 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.