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opencc-by-4.0May 2022View details →

Datasets underlying the paper 'Chemotactic self-caging in active emulsions'

Datasets supporting the figures 3-5 in 'Chemotactic self-caging in active emulsions' (in press, see also https://arxiv.org/abs/2012.05170)

opencc-by-4.0Jul 2022View details →

Stability characterization of microfluidic lipid-stabilized double emulsions under physiologically-relevant conditions

Double emulsions (DEs) are water-in-oil-in-water (or oil-in-water-in-oil) droplets with the potential to deliver combinatory therapies due to their ability to co-localize hydrophilic and hydrophobic molecules in the same carrier. However, DEs are thermodynamically unstable and only kinetically trapped. Extending this transitory state, rendering DEs more stable, would widen the possibilities of real-world applications, yet characterization of their stability in physiologically-relevant conditions is lacking. In this work, we used microfluidics to produce lipid-stabilized DEs with reproducible monodispersity and high encapsulation efficiency. We investigated DE stability under a range of physico-chemical parameters such as temperature, pH and mechanical stimulus. Stability through time was inversely proportional to temperature. DEs were significantly stable up to 8 days at 4 oC, 5 days at RT and 2 days at 37 oC. When encapsulating a cargo, DE stability decreased significantly. When exposed to a pH change, unloaded DEs were only significantly unstable at the extremes (pH 1 and 13), largely outside physiological ranges. When exposed to flow, unloaded DEs behaved similarly regardless of the mechanical stimulus applied, with approximately 70% remaining after 100 flow cycles of 10s. These results indicate that lipid-stabilized DEs produced via microfluidics could be tailored to endure physiologically-relevant conditions and act as carriers for drug delivery. Special attention should be given to the composition of the solutions, e.g. osmolarity ratio between inner and outer solutions, and the interaction of the molecules, e.g. carrier and cargo, involved in the final formulation.

opencc-by-4.0Apr 2023View details →

Carnauba Wax and Beeswax as Structuring Agents for Water-in-Oleogel Emulsions without Added Emulsifiers

This dataset contains the data used in the publication:  "Carnauba Wax and Beeswax as Structuring Agents for Water-in-Oleogel Emulsions without Added Emulsifiers"  (https://doi.org/10.3390/foods12091850)       Important abbreviations:  <ul> <li>#CRW: Indicates the concentration of carnauba wax in the fat phase (e.g., 5CRW - indicates 5%w/w of carnauba wax in the fat phase)</li> <li>#BZW: Indicates the concentration of beeswax in the fat phase (e.g., 5BZW - indicates 5%w/w of beeswax in the fat phase)</li> <li>#W: The number preceding indicates the percentage of water in the sample (e.g., 40W indicates 40%w/w of water in the emulsion)</li> <li>t#: Indicates the number of days in storage (e.g. t1 indicates the sample was measured after 1 day of storage time)</li> <li>LS: Indicates that the sample was prepared on a lab scale</li> <li>PS: Indicates that the sample was prepared on a pilot scale</li> </ul> This dataset contains:  <ul> <li>Microscopies <ul> <li>PLM <ul> <li>Figure 6A - Pilot scale emulsion - 5% carnauba wax - 40% water  </li> <li>Figure 6D - Pilot scale oleogel - 5% carnauba wax  </li> <li>Figure 7A  - Pilot scale emulsion - 5% beeswax - 20% water</li> <li>Figure 7D - Pilot scale oleogel - 5% beeswax  </li> <li>Figure 8A - CRW-S - Lab scale oleogel - 5% carnauba wax</li> <li>Figure 8B - CRW-D - Pilot scale oleogel - 5% carnauba wax</li> <li>Figure 8C - BZW-S- Lab scale oleogel - 5% beeswax</li> <li>Figure 8D - BZW-D - Pilot scale oleogel - 5% beeswax  </li> </ul> </li> <li>Cryo-SEM <ul> <li>Figure 6B -  Pilot scale emulsion - 5% carnauba wax - 40% water   </li> <li>Figure 6E -  Pilot scale oleogel - 5% carnauba wax  </li> <li>Figure 7B - Pilot scale emulsion - 5% beeswax - 20% water </li> <li>Figure 7E - Pilot scale oleogel - 5% beeswax  </li> </ul> </li> <li>CLSM <ul> <li>Figure 6C - Lab scale emulsion - 5% carnauba wax - 40% water  </li> <li>Figure 6F - Lab scale oleogel - 5% carnauba wax  </li> <li>Figure 7C - Lab scale emulsion - 5% beeswax - 40% water</li> <li>Figure 7F - Lab scale oleogel - 5% beeswax <ul> </ul> </li> </ul> </li> </ul> </li> </ul>   <ul> <li>Rheology data  <ul> <li>Strain sweeps <ul> <li>LS_2.5CRW_20W_t1.txt - Lab scale emulsion  - 2.5% carnauba wax - 20% water - day 1</li> <li>LS_5CRW_0W_t1.txt - Lab scale oleogel - 5% carnauba wax - day 1</li> <li>LS_5CRW_20W_t1.txt - Lab scale emulsion - 5% carnauba wax - 20% water - day 1</li> <li>LS_5CRW_30W_t1.txt - Lab scale emulsion - 5% carnauba wax - 30% water - day 1</li> <li>LS_5CRW_40W_t1.txt - Lab scale emulsion - 5% carnauba wax - 40% water - day 1</li> <li>LS_7.5CRW_20W_t1.txt - Lab scale emulsion- 7.5% carnauba wax - 20% water - day 1  </li> <li>LS_1.5BZW_20W_t1.txt - Lab scale emulsion - 1.5% beeswax - 20% water - day 1</li> <li>LS_2.25BZW_20W_t1.txt - Lab scale emulsion - 2.25% beeswax - 20% water - day 1 </li> <li>LS_5BZW_0W_t1.txt - Lab scale oleogel - 5% beeswax - day 1</li> <li>LS_5BZW_20W_t1.txt - Lab scale emulsion - 5% beeswax - 20% water - day 1</li> <li>LS_5BZW_30W_t1.txt - Lab scale emulsion - 5% beeswax - 30% water - day 1</li> <li>LS_5BZW_40W_t1.txt - Lab scale emulsion - 5% beeswax - 40% water - day 1  </li> <li>PS_5BZW_0W_t1.txt - Pilot scale oleogel - 5% beeswax - day 1</li> <li>PS_5BZW_20W_t1.txt - Pilot scale emulsion - 5% beeswax - 20% water - day 1</li> <li>PS_5BZW_40W_t1.txt - Pilot scale emulsion - 5% beeswax - 40% water - day 1</li> <li>PS_5CRW_0W_t1.txt - Pilot scale oleogel - 5% carnauba wax - day 1</li> <li>PS_5CRW_20W_t1.txt - Pilot scale emulsion - 5% carnauba wax - 20% water - day 1</li> <li>PS_5CRW_40W_t1.txt - Pilot scale emulsion - 5% carnauba wax - 40% water - day 1  </li> </ul> </li> <li>Data compilation: <ul> <li>Rheology - Average.csv Please consider the following abbreviations in the file <ul> <li>CGC = Critical gelling concentration</li> <li>G' = Storage modulus</li> <li>G'' = Loss modulus</li> <li>G* = Complex modulus</li> <li>Strain LVE = Yield strain </li> <li>COP = Crossover point</li> <li>NaN = indicates that the system was not stable and thus not measured</li> <li>Data is presented as Avgerave ± Standard Deviation (of the three repetitions)</li> </ul> </li> </ul> </li> </ul> </li> </ul>   <ul> </ul>

opencc-by-4.0Aug 2023View details →

Dataset for article: Structure Formation in Tailor-Made Buriti Oil Emulsion During Simulated Digestion

Dataset for publication: Structure Formation in Tailor-Made Buriti Oil Emulsion During Simulated Digestion Rafael V. M. Freire, Linda Hong, Miroslav Peterek, Stéphane Canarelli, Serge Rezzi, Stefan Salentinig Advanced Funtional Materials 2023 (DOI 10.1002/adfm.202303854) Setup and conditions for the experiments are described in the experimental section of the published (open access) manuscript. Data description in README.txt file.

opencc-by-4.0Nov 2021View details →

Dataset for "Molecular modeling of the interface of an egg yolk protein-based emulsion"

Dataset for figures of upcoming article "Molecular modeling of the interface of an egg yolk protein-based emulsion" submitted to the journal "Physics of Fluids". dimerApovitellenin1_AA.pdb is the all-atom protein structure file used in MD simulations. DPDparameters.csv is the parametrization file used in DPD simulations.

opencc-by-4.0Feb 2022View details →

A Multiplexed Cell-Free Assay to Screen for Antimicrobial Peptides in Double Emulsion Droplets

Data underlying the figures in the publication “A Multiplexed Cell-Free Assay to Screen for Antimicrobial Peptides in Double Emulsion Droplets”, published in Angew. Chem. Int. Ed., 2022, e202114632. <a href="https://onlinelibrary.wiley.com/doi/10.1002/anie.202114632">https://onlinelibrary.wiley.com/doi/10.1002/anie.202114632</a>   Table of contents: 1. Figure 1b: Bright-field image of the double emulsions droplets produced on the microfluidic chip (scale bar 40 μm). 2. Figure 1c: Source video of the image in Figure 1c. Overlaid fluorescence and bright-field image of a double emulsion in a hydrodynamic trap, containing LUVs loaded with a self-quenching concentration of SRB in the cell-free extract, showing background fluorescence (scale bar 20 μm). 3. Figure 2a: Excel file containing the experimental data for Figure 2a. Cell-free protein production. Cell-free production of sfGFP in double emulsion (DE) droplets. The expression and folding of sfGFP was confirmed by the increase of fluorescence at 516 nm (ex. 488 nm). The dashed ribbon represents standard deviation (n=150). 4. Figure 2c: Excel files containing the experimental data for Figure 2c. Mean fluorescence intensities of b) after incubation at room temperature for 16 hours. no DNA: DEs without any alpha-hemolys in plasmid DNA(n=107), α-HL:DEs with the alpha-hemolys in plasmid DNA(n=258), SDS: double emulsions without any alpha-hemolys in plasmid DNA, exposed to a solution of 0.5% SDS in buffer throughout the incubation (n=204). 5. Figure 2d: Excel file containing the experimental data for Figure 2d. Fluorophore leakage kinetics from mammalian-like LUVs with SRB and from bacteria-like LUVs with 6-FAM, induced by the cell-free expression of pneumolysin in a 384 well-plate, starting at time 0. Fractional fluorescence (fF) is calculated by setting the zero level to the vesicle fluorescence in the absence of DNA, and the maximum level of fluorescence, scaled to a value of 1, to the value obtained by lysing the vesicles with 0.5% SDS. Solid lines represent the average of three independent reactions visible below. 6. Figures 2e and 2f: FACS data for Figures 2e and 2f. 7. Figure 3a: Excel file containing the experimental data for Figure 3a.   Fluorophore leakage kinetics from mammalian-like LUVs with SRB and bacteria-like LUVs with 6-FAM, induced by the cell-free expression of meucin-25 in a 384 well-plate. Each well contained 8 nM of plasmid (Supporting Information Table 1). Solid lines represent the average of three technical replicates displayed as well (the lines are overlapping, thus not visible). 8. Figure 3c: Excel file containing the experimental data for Figure 3c.   Bacterial viability assay with increasing meucin-25 concentrations, measured by flow cytometry. Propidium iodide (PI) cannot pass intact bacterial membranes and only intercalates the DNA of permeabilized dead bacteria (“PI positive”). Constitutively expressed sfGFP proteins normally efficiently retained in intact bacterial cells (“GFPpositive”) but lost in suitably permeabilized cells. Error bars indicate standard deviation (n=10000). 9. Figure SI_2: Excel files containing the experimental data for Supplementary Figure 2. 10. Figure SI_3: Excel file containing the experimental data for Supplementary Figure 3. 11. Figure SI_4a: Excel files containing the experimental data for Supplementary Figure 4a. 12. Figure SI_4b: Excel files containing the experimental data for Supplementary Figure 4b. 13. Figure SI_5: Excel files containing the experimental data for Supplementary Figure 5. 14. Figure SI_6: Excel files containing the experimental data for Supplementary Figure 6.

Figure 4 in Survival of entomopathogenic nematodes in oil emulsions and control effectiveness on adult engorged ticks (Acari: Ixodida)

Figure 4: Effectivity of EPNs at concentration of 100 IJs/tick in vegetable oil emulsions at concentration of 33% on engorged adult ticks. Bars with unequal letters are statistically different (Tukey, P <0.05).

Figure 2 in Survival of entomopathogenic nematodes in oil emulsions and control effectiveness on adult engorged ticks (Acari: Ixodida)

Figure 2: Survival of EPNs in oil emulsions of J. VirGiniana and C. CitratUS at a concentration of 13% under laboratory conditions.

Figure 3 in Survival of entomopathogenic nematodes in oil emulsions and control effectiveness on adult engorged ticks (Acari: Ixodida)

Figure 3: Effectivity of EPNs at concentration of 50 IJs/tick in vegetable oil emulsions at concentration of 33% on engorged adult ticks. Bars with unequal letters are statistically different (Tukey, P <0.05).

Figure 5 in Survival of entomopathogenic nematodes in oil emulsions and control effectiveness on adult engorged ticks (Acari: Ixodida)

Figure 5: Control effectiveness of S. websteri at 119 IJs/tick in two vegetable oil emulsions at a concentration of 33% and a Control with S. websteri in only distilled water.

opencc-by-4.0Aug 2024View details →

Raw data: Amphiphilic nanogels as versatile stabilizers for Pickering emulsions

Raw data for Journal article: "Amphiphilic nanogels as versatile stabilizers for Pickering emulsions" Abstract:  Pickering emulsions (PEs) are stabilized by particles at the water/oil interface and exhibit superior long-term stability compared to emulsions with molecular surfactants. Among colloidal stabilizers, nano-/microgels facilitate emulsification and can introduce stimuli-responsiveness. While increasing their hydrophobicity is connected to phase inversion from oil-in-water (O/W) to water-in-oil (W/O) emulsions, a predictive model to relate this phase inversion to the molecular structure of the nano/microgel network remains missing. Addressing this challenge, we developed a library of amphiphilic nanogels (ANGs) that enable adjusting their hydrophobicity while maintaining similar colloidal structures. This enabled us to systematically investigate the influence of network hydrophobicity on emulsion stabilization. We found that W/O emulsions are preferred with increasing ANG hydrophobicity, oil polarity, and oil/water ratio. For non-polar oils, increasing emulsification temperature enabled the formation of W/O PEs that are metastable at room temperature. We connected this behavior to interfacial ANG adsorption kinetics and quantified ANG deformation and swelling in both phases via atomic force microscopy. Importantly, we developed a quantitative method to predict phase inversion by the difference in Flory-Huggins parameters between ANGs with water and oil ( χwater − χ oil). Overall, this study provides crucial structure-property relations to assist the design of new nano-/microgels for advanced PEs.

opencc-by-4.0Mar 2024View details →

Decoupling the rheological responses of a soft solid emulsion with liquid inclusions

Data used to write the paper Decoupling the rheological responses of a soft solid emulsion with liquid inclusions submitted to Journal of Physics: Condensed Matter for the Focus Issue on Materials with Liquid Inclusions (DOI: 10.1088/1361-648X/ad61ad)

opencc-by-4.0Feb 2022View details →

Raw data to "Opioid sequestration by intravenous lipid emulsion – comparison of lipophilicity in a cell-free system and cellular model"

Data that resulted from the conduction of the in vitro part of the project: Intravenous lipid emulsions as a treatment in acute opioid poisoning - pharmacokinetic and pharmacodynamic evaluation in the rabbit model. It served as raw data for the publication Opioid sequestration by intravenous lipid emulsion – comparison of lipophilicity in a cell-free system and cellular model (draft title).

opencc-by-4.0Mar 2022View details →

Data release for the paper "Measurements of protons and charged pions emitted from the $\nu_{\mu}$ charged-current interactions on iron at a mean neutrino energy of 1.49 GeV using a nuclear emulsion detector"

This data release is associated with the paper "Measurements of protons and charged pions emitted from the $\nu_{\mu}$ charged-current interactions on iron at a mean neutrino energy of 1.49 GeV using a nuclear emulsion detector". It is currently available on <a href="http://arxiv.org/abs/2203.08367">arXiv:2203.08367</a> and to be submitted to Phys. Rev. D. When citing this data release, please cite as well the paper. The provided zip file contains the data as below. <ol> <li>event.root: Event by event information of 183 iron-target interactions.</li> <li>plot.root: Plot information as shown in the paper.</li> <li>detector_efficiency.root: Detectrion efficiencies for muons, charged pions, and protons.</li> <li>momentum_resolution.root: Relation between true and reconstructed momentum for muons, charged pions, and protons.</li> <li>misPID.root: Mis-PID rates of protons and pions.</li> <li>syscov.root: Covariance matrices of systematic uncertainties.</li> <li>flux.root: The neutrino flux and the covariance matrix of the flux error.</li> </ol> The zip file also contains a README.pdf file with detailed information on the included files. Please read it.

Figure 1 in Survival of entomopathogenic nematodes in oil emulsions and control effectiveness on adult engorged ticks (Acari: Ixodida)

Figure 1: Survival of IJs in five vegetable oil emulsions at concentration of 13%.

opencc-by-4.0Nov 2018View details →

High performance cation exchange membranes synthesized via in-situ emulsion polymerization without organic solvents and corrosive acids

Dataset supporting journal publication: Abstract: The synthesis of cation exchange membranes (CEMs) usually involves using organic solvents and/or sulfonation process. In this study, green and scalable synthesis of high performance CEMs is achieved without organic solvents and sulfonation. The synthesis is carried out via in-situ polymerization of lithium styrene sulfonate in porous support. Different preparation procedures are developed and optimized. Functional sulfonate groups were successfully loaded onto and into the membrane support, as verified by FTIR. Besides, water plays an important role during membrane synthesis. By reducing the amount of water used, the ratio of functional polymers to membrane support in the synthesized CEMs is increased. Therefore, the synthesized CEMs show increased ion exchange capacity (IEC). This is significant because it means that high IEC can be achieved without introducing cation exchange resins to the membranes. Finally, the synthesized membranes demonstrate high desalination performance. This new methodology may shed new light on preparing CEMs in an efficient and eco-friendly way.

restrictedIPD-UNDECIDEDFeb 2026View details →

Physician's Evaluation of Cyclosporine Ophthalmic Emulsion 0.05%

ClinicalTrials.gov study NCT00827255. IPD Sharing: Not stated. Countries: 1. Publications: 1.

restrictedIPD-UNDECIDEDFeb 2026View details →

Use of a Modified Propofol Emulsion in Adults

ClinicalTrials.gov study NCT00690495. IPD Sharing: Not stated. Countries: 1. Publications: 1.

closedIPD-NOFeb 2026View details →

Compassionate Use of an Intravenous Fish Oil Emulsion in the Treatment of Liver Injury in Infants

ClinicalTrials.gov study NCT00738101. IPD Sharing: NO. Countries: 1. Publications: 27.