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72 results for “Enterovirus”
Field data for: Enterovirus sequence data obtained from primate samples in Central Africa suggest a high prevalence of enteroviruses with possible zoonotic potential
<p>Enteroviruses infect humans and animals, can cause disease, and some may be transmitted across species barriers. We collected different types of samples from various species of Central African wildlife, including data on sampling location and tested the samples for the presence of Enterovirus RNA using a family level PCR. Specimen collection was approved by an Institutional Animal Care and Use Committee (IACUC) of the University of California Davis, and the Governments of Cameroon and the Democratic Republic of the Congo. Enterovirus RNA was detected in samples from 17 primates and 2 rodents. Some sequences were very similar while others were dissimilar to known species, highlighting the unexplored enterovirus diversity in wildlife.</p> <p>The samples and filed data were collected by field ecologists as part of the USAID funded PREDICT project (https://ohi.vetmed.ucdavis.edu/programs-projects/predict-project) and screened for enterovirus RNA using consensus PCR. Maps were generated using basic maps from Paintmaps (http://www.paintmaps.com), a free tool for educational and academic use. The dataset contains the metadata on enterovirus screening among wildlife in Cameroon and the Democratic Republic of the Congo from 2003-2014 as part of the USAID funded PREDICT project. Please refer to the article for more information on methods and references.</p>
Data for Corre et al., Bacterial matrix metalloproteases and serine proteases contribute to the extra-host inactivation of enterovirus in lake water, ISMEJ 2022
<p>Data for Corre et al., <em>Bacterial matrix metalloproteases and serine proteases contribute to the extra-host inactivation of enterovirus in lake water</em>, ISMEJ 2022</p> <p>The first file contains all data pertaining to experiments with isolates: collection date, isolation temperature, protease activity measured by 4 different approaches, antiviral effect on E11 and CVA9 (three replicates each); this table corresponds to the data shown in Supplementary Table 2.</p> <p>The second file contains the raw data for all lake water experiments (Figures 1 and 6): information on sample type, antiviral effect (measured in triplicate), presence of a protease inhibitor.</p>
Structure and dynamics of enterovirus genotype networks
<p>Like all biological populations, viral populations exist as networks of genotypes connected through mutation. Mapping the topology of these networks and quantifying population dynamics across them is crucial to understanding how populations adapt to changes in their selective environment. The influence of mutational networks is especially profound in viral populations which rapidly explore their mutational neighborhoods via high mutation rates. Using a novel single-cell sequencing method, scRNAseq-Enabled Acquisition of mRNA and Consensus Haplotypes Linking Individual Genotypes and Host Transcriptomes (SEARCHLIGHT), we captured and assembled viral haplotypes from hundreds of individual infected cells to reveal the complexity of viral populations. We obtained these genotypes in parallel with host cell transcriptome information, enabling us to link host cell transcriptional phenotypes to the genetic structures underlying virus adaptation. Our examination of these structures reveals the common evolutionary dynamics of enterovirus populations and illustrates how viral populations reach through mutational 'tunnels' to span evolutionary landscapes and maintain connection with multiple adaptive genotypes simultaneously.</p>
Uncovering structural plasticity of Enterovirus A through deep insertional and deletional scanning
<p>Insertions and deletions (InDels) are essential sources of novelty in protein evolution. In RNA viruses, InDels cause dramatic phenotypic changes that contribute to the emergence of viruses with altered immune profiles and host engagement. This work aims to comprehensively quantify the mutational tolerance of an RNA virus to insertion, deletion, and substitution. Using Enterovirus A71 (EV-A71) as a prototype for the Enterovirus A species (EV-A) of picornaviruses, we engineered approximately 45,000 insertions, 6,000 deletions, and 41,000 amino acid changes across the 2,193 coding positions of the EV-A71 proteome, quantifying their effects on viral fitness and comprehensively mapping evolutionary constraint across the viral proteome. In contrast with amino acid changes, the vast majority of InDels are lethal to virus growth. Most that are tolerated reside at a few hotspot regions. These tolerant sites highlight structurally flexible and mutationally plastic regions of EV-A71 proteins that avoid core structural and functional elements, but often overlap with key sites of host- and immune recognition, suggesting a complex evolutionary role for InDels and substitutions at these sites. Phylogenetic analysis examining EV-A species isolated from diverse mammalian hosts reveals that many of the experimentally identified hotspots also correspond to sites of natural InDel diversity across the more diverse EV-A species, suggesting these hotspots of mutational tolerance in EV-A genomes may have contributed to past phenotypic diversification of EV-A. Insights from this and future mutational scanning studies mapping viral evolutionary potential will inform better epidemiological monitoring and Enterovirus vaccine development.</p>
Data for: Selective elimination of enterovirus genotypes by activated sludge and chlorination
<p>Raw data underlying the journal article "Selective elimination of enterovirus genotypes by activated sludge and chlorination" by Larivé et al., <em>Environmental Science: Water Research and Technology</em>, 2023 (doi: 10.1039/d3ew00050h)</p> <p>One CSV file for each of Figures 2-6 of the main manuscript $</p> <p>One CSV file for each of Figures S5, S6 and S7 of the Supplementary information. The data for Figures S2, S3 and S4 are summarized in a single CSV file.</p>
Structure and dynamics of enterovirus genotype networks
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A comprehensive map of evolutionary constraints across the enterovirus A genome
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Data from: Major group-B enterovirus populations deleted in the noncoding 5' region of genomic RNA modulate activation of the type I interferon pathway in cardiomyocytes and induce myocarditis
<p>Major 5'-terminally deleted (5'TD) RNA forms of group-B coxsackievirus (CVB-5'TD) has been associated with myocarditis in both mice and humans. Although it is known that interferon-β (IFN-β) signaling is critical for an efficient innate immune response against CVB-induced myocarditis, the link between CVB-5'TD RNA forms and type I IFN signaling in cardiomyocytes remains to be explored. In a mouse model of CVB3/28-induced myocarditis, major early-emerging forms of CVB-5'TD RNA have been characterized as replicative viral populations that impair IFN-β production in the heart. Synthetic CVB3/28 RNA forms mimicking each of these major 5'TD virus populations were transfected in mice and have been shown to modulate innate immune responses in the heart and to induce myocarditis in mice. Remarkably, transfection of synthetic viral RNA with deletions in the secondary structures of the 5'-terminal CVB3 RNA domain I, modifying stem-loops "b", "c" or "d", were found to impair IFN-β production in human cardiomyocytes. In addition, the activation of innate immune response by Poly(I:C), was found to restore IFN-β production and to reduce the burden of CVB-5'TD RNA-forms in cardiac tissues, thereby reducing the mortality rate of infected mice. Overall, our results indicate that major early-emerging CVB3 populations deleted in the domain I of genomic RNA, in the 5' noncoding region, modulate the activation of the type I IFN pathway in cardiomyocytes and induce myocarditis in mice. These findings shed new light on the role of replicative CVB-5'TD RNA forms as key pathophysiological factors in CVB-induced human myocarditis.</p>
Phase 1, Randomized, Double-Blind, Placebo-controlled Study to Evaluate the Safety and Tolerability of an Enterovirus D68-specific Monoclonal Antibody in Healthy Adults
ClinicalTrials.gov study NCT06444048. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Major group-B enterovirus populations deleted in the noncoding 5' region of genomic RNA modulate activation of the type I interferon pathway in cardiomyocytes and induce myocarditis
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Data for: Torii et al.,Observed Kinetics of Enterovirus Inactivation by Free Chlorine Are Host Cell-Dependent, Environmental Science and Technology, 10.1021/acs.est.2c07048
<p>This folder contains the experimental data to the figures shown in the main manuscript and Supporting Information.</p> <p>- Figure 1 (Inactivation curves for E11 by free chlorine, UV, and heat)</p> <p>- Figure 2 (Inactivation curves for CVA9, CVB1, E7, E9, and E13)</p> <p>- Figure S1 (Loss of attachment and the PCR-target by free chlorine treatment)</p> <p>- Figure S2 (Flow cytometric analysis)</p> <p> </p> <p> </p> <p> </p>
Immunogenicity and Safety of Three Consecutive Lots of a New Inactivated Enterovirus Type 71 (EV71) Vaccine
ClinicalTrials.gov study NCT01636245. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Five-year Immune Persistence Study of Inactivated Enterovirus Type 71 (EV71) Vaccine
ClinicalTrials.gov study NCT03281174. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An Efficacy Trial in Inactivated Enterovirus Type 71 (EV71) Vaccine
ClinicalTrials.gov study NCT01507857. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Phase IVb of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Children
ClinicalTrials.gov study NCT03001986. IPD Sharing: NO. Countries: 1. Publications: 1.
Characterization of Cytokines Expression During Enterovirus Meningitis in Paediatric Populations.
ClinicalTrials.gov study NCT04711876. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Live Enterovirus Vaccine and Type 1 Diabetes
ClinicalTrials.gov study NCT02961595. IPD Sharing: NO. Countries: 0. Publications: 1.
Clinical Trial of Enterovirus 71（EV71） Inactivated Vaccine in Children Aged 36-71 Months
ClinicalTrials.gov study NCT03909074. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety of an Inactivated Enterovirus Type 71 Vaccines in Healthy Children
ClinicalTrials.gov study NCT01273246. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Safety of an Inactivated Enterovirus Type 71 Vaccine in Healthy Adults
ClinicalTrials.gov study NCT01273233. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.