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1,383 results for “Estrogen”
Dataset for FigS2F in "DNA is the allosteric driver for the asymmetric binding of homodimer estrogen-related receptor"
<p><strong>Abstract</strong></p> <p>The estrogen-related receptors (ERRs, NR3B), orphan members of the steroid hormone receptor (SR) subfamily (NR3), are crucial for the transcriptional control of cellular energy metabolism. As basal members of NR3 subfamily, the ERRs are key elements for the understanding of how the binding of SRs to DNA evolved from monomeric to dimeric palindromic binding sites. To unravel the initial steps of DNA selection by SRs, we combined structural, biophysical and phylogenetic studies. Our results unveil the molecular mechanisms of the ERR dimerization which are imprinted in the protein itself with DNA acting as an allosteric driver by allowing the formation of a novel extended asymmetric dimerization region (KR-box). Phylogenetic analyses suggest that the dimerization asymmetry used by ERRs is an ancestral feature necessary for establishing a strong overall dimerization interface, which was progressively lost in the course evolution by other SRs.</p> <p><strong>Methods</strong></p> <p>Ancestral character reconstruction and stochastic mapping were performed under R version 4.1.2 using the make.simmap function as implemented in the phytools package version 1.0-1. Character evolution was inferred using a model of symmetrical transition rates between the character states (SYM). 10 000 character histories were sampled to allow the incorporation of the uncertainty associated with the transition between different states. Inferred state frequencies for ancestral nodes were plotted using the describe.simmap function.</p> <p><strong>Usage Notes</strong></p> <p>This dataset contains all the files necessary to reproduce Figure S2 of the associated paper (Patel et al., in preparation). Those files are:</p> <p>- script_FigS2F.R : the R script necessary to load the data and process them as indicated in the methods section. The outputs of character mappings are also indicated in the script file, in order that the user can compare them with the results he would get on his/her own computer.</p> <p>- tree_FigS2F.nex: the backbone tree used for character mapping</p> <p>- FigS2F_KR_box.csv: the data table containing the presence-absence data regarding the KR box motif for each nuclear receptor.</p>
Training data for ChIP-seq data analysis (Galaxy Training Material): Identification of the binding sites of the Estrogen receptor
<p>The data provided here are part of a Galaxy Training Network tutorial that analyzes ChIP-seq data from a study published by Ross-Inness et al., 2012 (DOI:10.1038/nature10730) to identify the binding sites of the Estrogen receptor, a transcription factor known to be associated with different types of breast cancer.</p>
Safety and Efficacy Study of Sapanisertib in Combination With Exemestane or Fulvestrant in Postmenopausal Women With Estrogen Receptor Positive/Human Epidermal Growth Factor Receptor 2 Negative (ER+/H
ClinicalTrials.gov study NCT02049957. IPD Sharing: YES. Countries: 3. Publications: 1.
A Study of Everolimus Plus Exemestane in Chinese Postmenopausal Women With Estrogen Receptor Positive, Locally Advanced, Recurrent, or Metastatic Breast Cancer After Recurrence or Progression on Non-s
ClinicalTrials.gov study NCT03312738. IPD Sharing: YES. Countries: 1. Publications: 1.
Selective Estrogen Receptor Modulators to Enhance the Efficacy of Viral Reactivation With Histone Deacetylase Inhibitors
ClinicalTrials.gov study NCT03382834. IPD Sharing: YES. Countries: 2. Publications: 1.
Phase 1/2 Study of Amcenestrant (SAR439859) Single Agent and in Combination With Other Anti-cancer Therapies in Postmenopausal Women With Estrogen Receptor Positive Advanced Breast Cancer
ClinicalTrials.gov study NCT03284957. IPD Sharing: YES. Countries: 10. Publications: 1.
Selected Fungicides as Potential EDC Estrogenic Micropollutants in the Environment
<p>The aim of the conducted studies was to check the activity of active substances of selected fungicides: boscalid, cyprodinil and iprodione and to analyze their potential estrogenic activity. The studies were carried out using two model cell lines MCF-7 and T47D- KBluc. The cells were selected for their response to 17ß-estradiol, which meant that they could be used to study estrogenic or antiestrogenic activity of chemical substances. The cytotoxic activity of the fungicides tested was assessed using the MTT test on two cell lines. The estrogen receptor (ER) reporter gene test was performed, which is referred to as the T47D-KBluc test. The E-Screen test was performed on the MCF-7 line, the principle of which is based on the increased proliferation of human breast cancer cells in the presence of substances with potential estrogenic activity. ROS content and zeta potential were also estimated. </p>
Pulsed administration for physiological estrogen replacement in mice
<p>In this study, mice were ovariectomized and treated with physiological doses of 17β-estradiol-3-benzoate (E2) dissolved in miglyol or PBS. Subcutaneous injections were performed every 4 days to resemble the estrus cycle in mice. Results show that OVX induces an osteoporotic phenotype, fat accumulation and impairment of the locomotor ability, as expected. Pulsed administration of physiological doses of E2 dissolved in miglyol rescues the phenotypes induced by OVX. However, when E2 is dissolved in PBS the effects are less pronounced, possibly due to rapid wash out of the steroid.</p>
Seasonal changes of vomeronasal responses to chemosensory cues associated with circulating estrogen in the female muskrats (Ondatra zibethicus)
<p>In numerous animals, the vomeronasal organ (VNO) is a crucial chemosensory organ that receives chemical signals, which is involved in species-specific behaviors, including social and sexual behaviors. Muskrat (<em>Ondatra</em> <em>zibethicus</em>) has a sensitive VNO system that detects specific chemicals such as pheromones and hormones and induces seasonal breeding behaviors. The purpose of this study is to investigate the distributions and expression patterns of vomeronasal receptor type-1 (V1R), vomeronasal receptor type-2 (V2R), estrogen receptors α and β (ERα and ERβ) in the female muskrats' VNO during the different periods. V1R, V2R, ERα and ERβ were found in sensory epithelial cells, non-sensory epithelial cells and lamina propria cells of the female muskrats' VNO. V2R and ERα mRNA levels in the VNO of the breeding period declined sharply, in comparison to those of the non-breeding period, while V1R and ERβ mRNA levels were detected reversely. Additionally, a transcriptomic study in the VNO identified that differentially expressed genes might be related to estrogen signals and metabolic pathways. These findings suggested that the seasonal structural and functional changes of VNO in the female muskrats within different reproductive statuses, and estrogen regulated its function through binding to ERα and ERβ in the female muskrats' VNO.</p>
A INTERVENTIONAL CROSS SECTIONAL STUDY BETWEEN INTRA VAGINAL PLATELET RICH PLASMA AND ESTROGEN FOR TREATMENT OF GENITO-URINARY SYNDROME IN POST MENOPAUSAL WOMEN.
<p>Genitourinary syndrome of menopause (GSM) is a new term for a condition more renowned as atrophic vaginitis. It is used to describe a variety of menopausal symptoms and signs that are related to the physical changes of the vulva, vagina and lower urinary tract. The etiology of GSM is secondary to decreased levels of endogenous estrogens and represents a common but underreported condition. Currently Intra-Vaginal application of oestrogen has been considered an effective treatment of atrophic vaginitis.Recently, PRP has becoming popular as a non-operative treatment option for GSM symptoms.Our study focuses on the use platelet rich plasma for the treatment of GSM as it has natural mechanisms of cell regeneration and requires less frequent dosing and have better compliance when compared to estrogen creams. Purpose of the study is to compare the effectiveness of intra vaginal estrogen cream with intravaginal PRP in treatment of GSM.</p>
A Study Evaluating the Efficacy and Safety of Giredestrant Compared With Physician's Choice of Endocrine Monotherapy in Participants With Previously Treated Estrogen Receptor-Positive, HER2-Negative L
ClinicalTrials.gov study NCT04576455. IPD Sharing: YES. Countries: 17. Publications: 2.
Synthetic vs Natural Estrogen in Combined Oral Contraception
ClinicalTrials.gov study NCT02352090. IPD Sharing: Not stated. Countries: 1. Publications: 4.
BI 836845 in Estrogen Receptor Positive Metastatic Breast Cancer
ClinicalTrials.gov study NCT02123823. IPD Sharing: YES. Countries: 10. Publications: 2.
Zoledronic Acid - Letrozole Adjuvant Synergy Trial (ZFAST) - Cancer Treatment Related Bone Loss in Postmenopausal Women With Estrogen Receptor Positive and/or Progesterone Receptor Positive Breast Can
ClinicalTrials.gov study NCT00050011. IPD Sharing: Not stated. Countries: 2. Publications: 1.
The Menopause Transition: Estrogen Variability, Stress Reactivity and Mood
ClinicalTrials.gov study NCT03003949. IPD Sharing: YES. Countries: 1. Publications: 1.
Study Evaluating The Effects Of Bazedoxifene/Conjugated Estrogens On Endometrial Safety And Postmenopausal Osteoporosis
ClinicalTrials.gov study NCT00808132. IPD Sharing: Not stated. Countries: 12. Publications: 2.
A Clinical Trial to Evaluate the Safety and Efficacy of DR-2041(Synthetic Conjugated Estrogens, A) for Treatment of Vulvovaginal Atrophy
ClinicalTrials.gov study NCT00361569. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Estrogen and Hot Flashes on Mood in Postmenopausal Women
ClinicalTrials.gov study NCT01126801. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pilot Study of Femring Estrogen Supplementation During Depo-Provera Initiation
ClinicalTrials.gov study NCT00563576. IPD Sharing: Not stated. Countries: 1. Publications: 17.
The Role of Estrogen in Luteinizing Hormone Surge and Ovulation
ClinicalTrials.gov study NCT01999569. IPD Sharing: NO. Countries: 1. Publications: 7.
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