Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
50
datasets available to search
ShareScore release 0.9.0
Dataset results
50 results for “Experimental autoimmune encephalomyelitis”
Flow cytometry of mesenteric lymph nodes, small and large intestinal lamina propria, and spinal cord cells from fibre-rich and fiber-free diet-fed gnotobiotic mice at baseline and after experimental autoimmune encephalomyelitis (EAE) induction
<p>We perform profiling of different immune cell populations in the small (SILP) and large intestine lamina propria (CLP), mesenteric lymph nodes (MLN) and spinal cords (SC). We are specifically interested to evaluate the impact of dietary fiber deprivation followed by mucus erosion on the immune cell profiles of T helper cells (Th cells, T cell population) of gnotobiotic mice fed a fiber-rich (FR) or fiber-free (FF) diet. This dataset aims to assess the impact of microbiome and diet on disease course in a mouse model of multiple sclerosis (experimental autoimmune encephalomyelitis, EAE) via T cell populations. Mice are either germ-free or colonized by intragastric gavage with a defined variation of a 14-member synthetic human gut microbiome (doi: 10.1016/j.cell.2016.10.043 and 10.1016/j.xpro.2021.100607): SM01 (Akkermansia muciniphila monocolonisation), SM03 (Bacteroides caccae, Bacteroides thetaiotaomicron, Barnesiella intestinihominis), SM04 (B. caccae, B. thetaiotaomicron, B. intestinihominis, A. muciniphila), SM12 (full community except mucin-specialists B. intestinihominis and A. muciniphila), SM13 (full community except mucin specialist A. muciniphila), or SM14 (full community: Roseburia intestinalis, Faecalibacterium prausnitzii, Marvinbryantia formatexigens, Collinsella aerofaciens, Desulfovibrio piger, B. caccae, B. thetaiotaomicron, Bacteroides ovatus, Bacteroides uniformis, B. intestinihominis, Eubacterium rectale, Clostridium symbiosum, Escherichia coli, and A. muciniphila). At age 5 to 8 weeks, mice were colonized with SM combinations while fed an FR diet. Mice were either maintained on an FR diet or switched to an FF diet at 5 days after initial colonization, until the end of experiment. Baseline samples were collected 20 days following the diet switch. Otherwise, EAE induction was performed 15 days after the diet switch and samples were collected 30 days after the induction.</p>
Dataset of Molecular Dynamics Simulations for the Upregulated Biomarker PSMB8: 3UNF and its G210V Mutant in Experimental Autoimmune Encephalomyelitis
<p>This dataset contains molecular dynamics simulations data generated using GROMACS for the upregulated biomarker 3UNF and its G210V mutant in the context of Experimental Autoimmune Encephalomyelitis (EAE). EAE is a widely studied animal model for multiple sclerosis, and investigating the behavior of biomarkers in this model is crucial for understanding disease progression and potential therapeutic interventions.</p> <p>The dataset includes trajectory files, coordinate files, and relevant parameters used in the simulations. These simulations provide valuable insights into the structural dynamics, conformational changes, and interactions of the PSMB8 biomarker 3UNF and its G210V mutant within the EAE system. The data offers researchers an opportunity to analyze and explore the behavior of these biomarkers at the atomic level, aiding in the identification of potential binding partners, functional sites, and mechanisms associated with disease progression.</p> <p>By sharing this dataset, we aim to contribute to the scientific community by providing a valuable resource for further analysis, validation, and comparison of the molecular behavior of the upregulated biomarker 3UNF and its G210V mutant in Experimental Autoimmune Encephalomyelitis.</p>
subventricular zone progenitors healthy vs. Experimental Autoimmune Encephalomyelitis mice
GEO Series GSE47486. Mus musculus. 4 samples. Type: Expression profiling by array.
RNA sequencing of monocytes and microglia from mice with experimental autoimmune encephalomyelitis illustrates a changing phenotype with disease course
GEO Series GSE59725. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiling of astrocyte subtypes in naive mice and during experimental autoimmune encephalomyelitis
GEO Series GSE136358. Mus musculus. 84 samples. Type: Expression profiling by high throughput sequencing.
Distinctive waves of innate immune response in the retina in experimental autoimmune encephalomyelitis
GEO Series GSE173378. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Therapeutic effects of telomerase-derived peptide GV1001 in experimental autoimmune encephalomyelitis: inhibiting neuroinflammation and promoting remyelination
GEO Series GSE304238. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Analysis of a non-obese diabetes-experimental autoimmune encephalomyelitis (NOD-EAE)
GEO Series GSE243235. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
MAIT cells in experimental autoimmune encephalomyelitis (EAE)
GEO Series GSE234291. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Single-Cell Transcriptomics Identifies Brain Endothelium Inflammatory Networks in Experimental Autoimmune Encephalomyelitis
GEO Series GSE199460. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiles of MBP-specific T cells during experimental autoimmune encephalomyelitis
GEO Series GSE75488. Rattus norvegicus. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiling and multiple machine learning methods identified novel microglia biomarkers for Experimental Autoimmune Encephalomyelitis
GEO Series GSE253318. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Interferon-gamma ameliorates experimental autoimmune encephalomyelitis by inducing homeostatic adaptation of microglia
GEO Series GSE231833. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Experimental Autoimmune Encephalomyelitis is Associated with Changes of the Microbiota Composition in the Gastrointestinal Tract
GEO Series GSE153118. Mus musculus; blank sample. 91 samples. Type: Other.
Immunoregulatory Effect of Microparticle Delivered STING Agonist in the Control of Experimental Autoimmune Encephalomyelitis (EAE) and Multiple Sclerosis (MS)
ClinicalTrials.gov study NCT05705986. IPD Sharing: Not stated. Countries: 1. Publications: 0.
CNS-endogenous TLR7 and TLR9 induce different immune responses and effects on experimental autoimmune encephalomyelitis
GEO Series GSE172083. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
miRNAs expression in spinal cords of experimental autoimmune encephalomyelitis (EAE) mice
GEO Series GSE37424. Mus musculus. 4 samples. Type: Expression profiling by RT-PCR.
Integrin α3-dependent gene expression in Th17 cells generated during experimental autoimmune encephalomyelitis
GEO Series GSE214418. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
CLIPseq of hnRNP A1 from the spinal cords of mice with experimental autoimmune encephalomyelitis
GEO Series GSE208093. Mus musculus. 22 samples. Type: Other.
Endothelial cell-derived oxysterol ablation attenuates experimental autoimmune encephalomyelitis
GEO Series GSE217431. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.