Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
75
datasets available to search
ShareScore release 0.7.1
Dataset results
75 results for “Ferritin”
The Efficacy of Daily versus Weekly Ferrous Sulfate in Maintaining Normal Serum Ferritin Levels During Pregnancy: A Randomized Controlled Trial
<p>Serum ferritin is the most reliable indication of stored iron in pregnancy, offering a<br>noninvasive way to detect iron deficiency anemia before it occurs. Therefore, this study aimed to<br>determine serum ferritin levels among women receiving daily versus weekly iron supplementation,<br>with a secondary focus on comparing the proportion developing iron deficiency anemia and compli-<br>ance rates between the two groups.<br>Methods: This non-blinded randomized control trial involved non-anaemic pregnant women attend-<br>ing antenatal clinics at two Teaching Hospitals in Osun State. One hundred twenty-five subjects were<br>recruited to receive 65mg in the control group, while another 125 subjects in the active group re-<br>ceived three tablets (195mg) of ferrous sulfate (Fesulf) once weekly for 17 weeks from the 20th to<br>37th weeks of gestation. The primary outcome measure was comparing mean serum ferritin levels in<br>both groups at 37 weeks.<br>Results: Among the 240 subjects analyzed, the 37-week serum ferritin level was higher in the daily<br>group (73.26±26.67µg/L) compared to the weekly group (63.04±30.71 µg/L), p value=0.006. Four<br>(3.36%) and 10 (8.26%) of our subjects had Iron deficiency anaemia. Nine subjects (3.75%) reported<br>dyspepsia as a side effect. Daily 65 mg of Felsulf proved more effective than weekly 195mg in main-<br>taining normal blood ferritin levels during pregnancy.<br>Conclusions: Daily iron supplementation with 65mg ferrous sulfate was more effective at main-<br>taining adequate maternal iron concentration in this group of non-anaemic pregnant women. This<br>dosage is recommended for routine iron supplementation in our environment.</p>
Dose, Safety, Tolerability and Immunogenicity of an Influenza H1 Stabilized Stem Ferritin Vaccine in Healthy Adults
ClinicalTrials.gov study NCT03814720. IPD Sharing: NO. Countries: 1. Publications: 5.
Influenza HA Ferritin Vaccine, Alone or in Prime-Boost Regimens With an Influenza DNA Vaccine in Healthy Adults
ClinicalTrials.gov study NCT03186781. IPD Sharing: NO. Countries: 1. Publications: 5.
Dose, Safety, Tolerability and Immunogenicity of an Influenza H10 Stabilized Stem Ferritin Vaccine, VRC-FLUNPF0103-00-VP, in Healthy Adults
ClinicalTrials.gov study NCT04579250. IPD Sharing: NO. Countries: 1. Publications: 4.
Epstein-Barr Virus (EBV) gH/gL/gp42-Ferritin Nanoparticle Vaccine With or Without gp350-Ferritin in Healthy Adults With or Without EBV Infection
ClinicalTrials.gov study NCT06908096. IPD Sharing: YES. Countries: 1. Publications: 3.
Data from: Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila
Open the record for dataset details and reuse information.
Data from: Increased dietary intake of saturated fatty acid heptadecanoic acid (C17:0) associated with decreasing ferritin and alleviated metabolic syndrome in dolphins
Similar to humans, bottlenose dolphins (Tursiops truncatus) can develop metabolic syndrome and associated high ferritin. While fish and fish-based fatty acids may protect against metabolic syndrome in humans, findings have been inconsistent. To assess potential protective factors against metabolic syndrome related to fish diets, fatty acids were compared between two dolphin populations with higher (n = 30, Group A) and lower (n = 19, Group B) mean insulin (11 ± 12 and 2 ± 5 μIU/ml, respectively; P < 0.0001) and their dietary fish. In addition to higher insulin, triglycerides, and ferritin, Group A had lower percent serum heptadecanoic acid (C17:0) compared to Group B (0.3 ± 0.1 and 1.3 ± 0.4%, respectively; P < 0.0001). Using multivariate stepwise regression, higher percent serum C17:0, a saturated fat found in dairy fat, rye, and some fish, was an independent predictor of lower insulin in dolphins. Capelin, a common dietary fish for Group A, had no detectable C17:0, while pinfish and mullet, common in Group B's diet, had C17:0 (41 and 67 mg/100g, respectively). When a modified diet adding 25% pinfish and/or mullet was fed to six Group A dolphins over 24 weeks (increasing the average daily dietary C17:0 intake from 400 to 1700 mg), C17:0 serum levels increased, high ferritin decreased, and blood-based metabolic syndrome indices normalized toward reference levels. These effects were not found in four reference dolphins. Further, higher total serum C17:0 was an independent and linear predictor of lower ferritin in dolphins in Group B dolphins. Among off the shelf dairy products tested, butter had the highest C17:0 (423mg/100g); nonfat dairy products had no detectable C17:0. We hypothesize that humans' movement away from diets with potentially beneficial saturated fatty acid C17:0, including whole fat dairy products, could be a contributor to widespread low C17:0 levels, higher ferritin, and metabolic syndrome.
Data from: Concholepas concholepas Ferritin H-like subunit (CcFer): molecular characterization and single nucleotide polymorphism associated to innate immune response
Ferritin has been shown as the principal protein of iron storage and iron detoxification, playing a pivotal role for the cellular homeostasis in living organisms. However, recent studies in marine invertebrates have suggested its association with innate immune system. In the present study, one Ferritin subunit was identified from the gastropod Concholepas concholepas (CcFer), which was fully characterized by Rapid Amplification of cDNA Ends technique. Simultaneously, a challenge test was performed to evaluate the immune response against Vibrio anguillarum. The full length of cDNA Ccfer was 1,030 bp, containing 513 bp of open reading frame that encodes 170 amino acid peptides, which was similar to the Ferritin-H subunit described in vertebrates. Untranslated Regions (UTRs) were identified with a 5'UTR of 244 bp that contains iron responsive element (IRE), and a 3'UTR of 273 pb. The predicted molecular mass of deduced amino acid of CcFer was 19.66 kDa and isoelectric point of 4.92. Gene transcription analysis revealed that CcFer increases against infections with V. anguillarum, showing a peak expression at 6 hours post-infection. Moreover, a single nucleotide polymorphism was detected at -64 downstream 5'UTR sequence (SNP-64). Quantitative real time analysis showed that homozygous mutant allele (TT) was significantly associated with higher expression levels of the challenged group compared to wild (CC) and heterozygous (CT) variants. Our findings suggest that CcFer is associated to innate immune response in C. concholepas and that the presence of SNPs may involve differential transcriptional expression of CcFer.
Data from: In vivo tracking of dendritic cell using MRI reporter gene, ferritin
The noninvasive imaging of dendritic cells (DCs) migrated into lymph nodes (LNs) can provide helpful information on designing DCs-based immunotherapeutic strategies. This study is to investigate the influence of transduction of human ferritin heavy chain (FTH) and green fluorescence protein (GFP) genes on inherent properties of DCs, and the feasibility of FTH as a magnetic resonance imaging (MRI) reporter gene to track DCs migration into LNs. FTH-DCs were established by the introduction of FTH and GFP genes into the DC cell line (DC2.4) using lentivirus. The changes in the rate of MRI signal decay (R2*) resulting from FTH transduction were analyzed in cell phantoms as well as popliteal LN of mice after subcutaneous injection of those cells into hind limb foot pad by using a multiple gradient echo sequence on a 9.4 T MR scanner. The transduction of FTH and GFP did not influence the proliferation and migration abilities of DCs. The expression of co-stimulatory molecules (CD40, CD80 and CD86) in FTH-DCs was similar to that of DCs. FTH-DCs exhibited increased iron storage capacity, and displayed a significantly higher transverse relaxation rate (R2*) as compared to DCs in phantom. LNs with FTH-DCs exhibited negative contrast, leading to a high R2* in both in vivo and ex vivo T2*-weighted images compared to DCs. On histological analysis FTH-DCs migrated to the subcapsular sinus and the T cell zone of LN, where they highly expressed CD25 to bind and stimulate T cells. Our study addresses the feasibility of FTH as an MRI reporter gene to track DCs migration into LNs without alteration of their inherent properties. This study suggests that FTH-based MRI could be a useful technique to longitudinally monitor DCs and evaluate the therapeutic efficacy of DC-based vaccines.
Ferritin and Iron Burden in SAH sIRB
ClinicalTrials.gov study NCT03754725. IPD Sharing: NO. Countries: 1. Publications: 1.
Serum Ferritin Concentration and Fetal MCA Doppler as Predictors for Preterm Delivery
ClinicalTrials.gov study NCT02420743. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Ferritin Screening And IRon Treatment for Maternal Anemia and FGR Prevention Trial
ClinicalTrials.gov study NCT04228627. IPD Sharing: YES. Countries: 1. Publications: 3.
Maternal Serum Ferritin and Low Neonatal Birth Weight
ClinicalTrials.gov study NCT02738463. IPD Sharing: YES. Countries: 1. Publications: 5.
The Effect of Vitamin D3 Supplementation on Hepcidin and Ferritin Serum Levels in Children With Chronic Kidney Disease
ClinicalTrials.gov study NCT06706271. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety and Immunogenicity of an Epstein-Barr Virus (EBV) gp350-Ferritin Nanoparticle Vaccine in Healthy Adults With or Without EBV Infection
ClinicalTrials.gov study NCT04645147. IPD Sharing: YES. Countries: 1. Publications: 3.
Association of Serum Ferritin and Bone Mineral Density With Bone Metabolism in Chinese Healthy Postmenopausal Women
ClinicalTrials.gov study NCT03512743. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin)
ClinicalTrials.gov study NCT00224081. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Donor Breast Milk and Serum Ferritin Levels in Very Preterm Infants
ClinicalTrials.gov study NCT06843278. IPD Sharing: NO. Countries: 1. Publications: 13.
PHASE 1 SARS-COV-2-Spike-Ferritin-Nanoparticle (SpFN) Vaccine With ALFQ Adjuvant for Prevention of COVID-19
ClinicalTrials.gov study NCT04784767. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: In vivo tracking of dendritic cell using MRI reporter gene, ferritin
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.