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Dataset results
27 results for “GAL4”
Data for: A zinc-finger fusion protein refines Gal4-defined neural circuits
<p>This is microscopy image data and related information for</p> <p><strong>A zinc-finger fusion protein refines Gal4-defined neural circuits</strong></p> <p>The analysis of behavior requires that the underlying neuronal circuits are identified and genetically isolated. In several major model species—most notably Drosophila, neurogeneticists identify and isolate neural circuits with a binary, heterologous, expression control system: Gal4-UASG. One limitation of Gal4-UASG is that expression patterns are often too broad to map circuits precisely. To help refine the expression of Gal4 lines, we developed an intersectional genetic AND operator. Interoperable with Gal4, the new system’s key component is a fusion protein in which the DNA-binding domain of Gal4 has been replaced with a zinc finger domain with a different DNA-binding specificity. In combination with its cognate binding site (UASZ) the zinc-finger-replaced Gal4 (‘Zal1’) was functional as a standalone transcription factor. Zal1 transgenes also refined Gal4 expression ranges when combined with UASGZ, a hybrid upstream activation sequence. In this way, combining Gal4 and Zal1 drivers captured restricted cell sets compared with single drivers and improved genetic fidelity. This intersectional genetic AND operation presumably derives from the action of a heterodimeric transcription factor: Gal4-Zal1. Configurations of Zal1-UASZ and Zal1-Gal4-UASGZ are versatile tools for defining, refining, and manipulating targeted neural expression patterns with precision.</p>
Confocal image stacks of GFP expression in Drosophila forelegs driven by Gal4 driver expression in foreleg motor neurons
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LL Behaviour of TIM Gal4 > NKCC OX and NKCC OX / + flies
<p>Dataset of activity behaviour acquired with DAM2 systems for TIM Gal4 > NKCC OX and NKCC OX / + flies. The results are shown in <a href="https://doi.org/10.1073/pnas.1606547113">https://doi.org/10.1073/pnas.1606547113</a></p>
Gal4 clustering data
<p>Gal4 clustering data</p>
Analysed data of GAL10-Gal4 burst tracking and analysis
<p>Analyzed data of GAL10-Gal4 burst tracking and analysis</p>
Survey of GPCR gene expression in apterous-GAL4/+ Drosophila wing discs
GEO Series GSE169490. Drosophila melanogaster. 3 samples. Type: Expression profiling by high throughput sequencing.
Neurobehavioral phenotypes in the pan-neuronal GAL4 zebrafish line Tg(elavl3:KalTA4) - Addition of a second elavl3:KalTA4 bulk RNA-sequencing dataset.
GEO Series GSE302688. Danio rerio. 10 samples. Type: Expression profiling by high throughput sequencing.
ChIP-seq data from fkh-Gal4::UAS-rib-GFP and sage-Gal4::UAS-rib-GFP mid- through late-stage Drosophila embryos
GEO Series GSE73780. Drosophila melanogaster. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Next Generation Sequencing Facilitates Quantitative Analysis of Drosophila larval Wild Type and TFAM RNAi (r4-gal4>TFAM RNAi) Fat body Transcriptomes
GEO Series GSE198604. Drosophila melanogaster. 12 samples. Type: Expression profiling by high throughput sequencing.
A single Gal4-like transcription factor activates the Crabtree effect in Komagataella phaffii
GEO Series GSE110624. Komagataella phaffii. 9 samples. Type: Expression profiling by high throughput sequencing.
Overexpression of IBIN (CG44404) using C564-GAL4 driver enhances a group of Toll pathway target genes and shows effects on metabolism
GEO Series GSE120437. Drosophila melanogaster. 18 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile of Tra1 GID (Gal4 interaction defective) mutants
GEO Series GSE31389. Saccharomyces cerevisiae. 6 samples. Type: Expression profiling by array.
Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4
GEO Series GSE31391. Saccharomyces cerevisiae. 12 samples. Type: Expression profiling by array.
GAL4-responsive genes in larval salivary glands of late Drosophila prepupae
GEO Series GSE8620. Drosophila melanogaster. 7 samples. Type: Expression profiling by array.
Eye imaginal disc expressing transgenic human proinsulin in Drosophila eye under regulation of GMR-GAL4
GEO Series GSE43128. Drosophila melanogaster. 20 samples. Type: Expression profiling by array.
Comparison of gene expression in control bam-Gal4 and control undriven tbrd-2RNAi Drosophila testes with tbrd-2 knockdown testes
GEO Series GSE81019. Drosophila melanogaster. 9 samples. Type: Expression profiling by array.
RNA sequencing of nos-gal4>phf7ey Drosophila ovaries
GEO Series GSE150213. Drosophila melanogaster. 2 samples. Type: Expression profiling by high throughput sequencing.
Senseless-responsive and GAL4-responsive genes in larval salivary glands of late Drosophila prepupae
GEO Series GSE8623. Drosophila melanogaster. 13 samples. Type: Expression profiling by array.
PolyA+ expression profiling of tubulin Gal4 driven targeted DamID in Drosophila melanogaster adults and gonads
GEO Series GSE115694. Drosophila melanogaster. 24 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling of Tg(14xUAS:GFP-EWSR1-ERG) x Et(E1b:Gal4-VP16)s1101t, Tg(UAS:Kaede) s1999t zebrafish embryos at 3 days post fertilization
GEO Series GSE62273. Danio rerio. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.