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120
datasets available to search
ShareScore release 0.9.0
Dataset results
120 results for “GMP”
ValRun: GMP-grade Manufacturing and Quality Control of a Non-Virally engineered Advanced Therapy Medicinal Product for Personalized Treatment of Age-Related Macular Degeneration
<p><strong>VaLRun: </strong></p> <p><strong>Raw data of "GMP-grade Manufacturing and Quality Control of a Non-Virally engineered Advanced Therapy Medicinal Product for Personalized Treatment of Age-Related Macular Degeneration"</strong></p> <p>(Excel-, pdf-, GraphPad-files, mp4 videos and a READ-ME text file)</p> <p>The introduction of new therapeutics requires validation of Good Manufacturing Practice (GMP)-grade manufacturing including suitable quality controls. This is challenging for Advanced Therapy Medicinal Products (ATMP) with personalized batches. We have developed a person-alized, cell-based gene therapy to treat age-related macular degeneration and established a vali-dation strategy of the GMP-grade manufacture for the ATMP; manufacturing and quality control were challenging due to a low cell number, batch-to-batch variability and short production duration. Instead of patient iris pigment epithelial cells, human donor tissue was used to produce the transfected cell product (“tIPE”). We implemented an extended validation of 104 tIPE productions. Procedure, operators and devices have been validated and qualified by determining cell number, viability, extracellular DNA, sterility, duration, temperature and volume. Transfected autologous cells were transplanted to rabbits verifying feasibility of the treatment. A container has been engineered to insure a safe transport from the production to the surgery site. Criteria for successful validation and qualification were based on tIPE’s Critical Quality Attributes and Process Parameters, its manufacture and release criteria. The validated process and qualified operators are essential to bring the ATMP into clinic and offer a general strategy for the transfer to other manufacture centers and personalized ATMPs.</p>
A simple model to calculate GMP from land fraction in palaeoclimate
<p>dataset and code for a simple model which calculate GMP from land fraction in palaeoclimate</p> <p>The dataset is in Netcdf form and the code is writen by python</p>
Supplementary Movie 1 from: A genetically encoded biosensor to monitor dynamic changes of c-di-GMP with high temporal resolution
<p>This record contains<strong> Supplementary Movie 1</strong> from:</p> <p><strong>A genetically encoded biosensor to monitor dynamic changes of c-di-GMP with high temporal resolution</strong></p> <p>Andreas Kaczmarczyk, Simon van Vliet, Roman Peter Jakob, Raphael Dias Teixeira, Inga Scheidat, Alberto Reinders, Alexander Klotz, Timm Maier, Urs Jenal</p> <p>Biozentrum, University of Basel, 4056 Basel, Switzerland</p> <p>Correspondence to: urs.jenal[at]unibas.ch, andreas.kaczmarczyk[at]unibas.ch</p> <p> </p>
The files for "RlmI-c-di-GMP" molecular dynamics simulation
<p>The crystal structure files (protein RlmI), MD simulation files (input files, parameter files, topology files etc) and structures of c-Di-GMP.</p>
Endocrine Cardiomyopathy: Response to Cyclic GMP PDE5 Inhibitors in Acromegaly Cardiomyopathy
ClinicalTrials.gov study NCT02611336. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Exploration of the Activity of DNA Located Outside of Cellular Nucleus to Amplify Inflammation in Inflammatory Bowel Disease in Children Through Biological Pathway Cyclic GMP-AMP Synthase (cGAS) - Sti
ClinicalTrials.gov study NCT05916274. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Endocrine Cardiomyopathy in Cushing Syndrome: Response to Cyclic GMP PDE5 inhibitOrs
ClinicalTrials.gov study NCT02611258. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Draft genome sequence of Xylaria bambusicola isolate GMP-LS, the root and basal stem rot pathogen of sugarcane in Indonesia
<p>Supplementary Figure 1</p><p>Supplementary Table 1</p><p>Supplementary Table 2</p>
Amino Acid Kinetics of GMP-AA in Healthy Human Volunteers
ClinicalTrials.gov study NCT05971563. IPD Sharing: NO. Countries: 1. Publications: 0.
The effect of beta-glucan - induced trained immunity on the transcriptomic profile of bone marrow granulocyte-macrophage progenitors (GMP)
GEO Series GSE139452. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling in murine granulocyte-monocyte progenitors (GMP), common dendritic cell progenitors (CDP), committed precursors of classical dendritic cells (pre-cDC), Ly6C+ monocytes (Mo),
GEO Series GSE84509. Mus musculus. 16 samples. Type: Expression profiling by array.
Using single-cell RNA-Seq for unbiased analysis of developmental hierarchies (single cell RNA Seq of Irf8-GFP GMP)
GEO Series GSE70241. Mus musculus. 37 samples. Type: Expression profiling by high throughput sequencing.
Use of transcriptome data to study the c-di-GMP signaling network in Pseudomonas aeruginosa clinical isolates
GEO Series GSE233207. Pseudomonas aeruginosa PAO1; Pseudomonas aeruginosa UCBPP-PA14; Pseudomonas aeruginosa. 24 samples. Type: Expression profiling by high throughput sequencing.
Pseudomonas aeruginosa post-translational responses to elevated c-di-GMP levels
GEO Series GSE183394. Pseudomonas aeruginosa PAO1. 20 samples. Type: Expression profiling by high throughput sequencing.
The cyanobacterial phytochrome 2 regulates the expression of motility-related genes through the second messenger cyclic di-GMP
GEO Series GSE116409. Synechocystis sp. PCC 6803. 8 samples. Type: Expression profiling by array.
A neutropenia-associated transcription factor mutation differentially impacts target genes in the cell-states traversed during granulocyte specification and commitment [CITE-seq-GMP-WT]
GEO Series GSE120365. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing; Other.
AML patient granulocyte macrophage progenitor (GMP) cells
GEO Series GSE161391. Homo sapiens. 3 samples. Type: Expression profiling by array; Third-party reanalysis.
Using single-cell RNA-Seq for unbiased analysis of developmental hierarchies (single cell RNA Seq of Gfi1-GFP GMP)
GEO Series GSE70238. Mus musculus. 39 samples. Type: Expression profiling by high throughput sequencing.
Identification of Kdm4a and c target genes in MLL-AF9 transformed mouse GMPs (L-GMP) [ChIP-seq]
GEO Series GSE81299. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
RNA-seq data of effects of DCPS inhibition in mouse AML cells (CALM/AF10) and in normal GMP cells. Overall mRNA profiles of CALM/AF10 (#1/#2) and MLL/AF9 (#1/#2).
GEO Series GSE107288. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.