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ShareScore release 0.9.0
Dataset results
19 results for “Genetic Circuits”
Plasmid Sequences for Brophy et al., 2022: Synthetic genetic circuits as a means of reprogramming plant roots
<p>Plasmid Sequences for Brophy et. al. 2022: Synthetic genetic circuits as a means of reprogramming plant roots</p>
Data for: Cooperative assembly confers regulatory specificity and long-term genetic circuit stability
<p>A ubiquitous feature of eukaryotic transcriptional regulation is cooperative self-assembly between transcription factors (TFs) and DNA cis-regulatory motifs. It is thought that this strategy enables specific regulatory connections to be formed in gene networks between otherwise weakly-interacting, low-specificity molecular components. Here, using synthetic gene circuits constructed in yeast, we find that high regulatory specificity can emerge from cooperative, multivalent interactions among artificial zinc finger-based TFs. We show that circuits 'wired' using the strategy of cooperative TF assembly are effectively insulated from aberrant misregulation of the host cell genome. As we demonstrate in experiments and mathematical models, this mechanism is sufficient to rescue circuit-driven fitness defects, resulting in genetic and functional stability of circuits in long-termcontinuous culture. Our naturally-inspired approach offers a simple, generalizable means for building high-fidelity, evolutionarily robust gene circuits that can be scaled to a wide range of host organisms and applications.</p>
Data for: Cooperative assembly confers regulatory specificity and long-term genetic circuit stability
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Data from: Phylogeography in continuous space: coupling species distribution models and circuit theory to assess the effect of contiguous migration at different climatic periods on genetic differentiation in Busseola fusca (Lepidoptera: Noctuidae)
Current population genetic models fail to cope with genetic differentiation for species with large, contiguous and heterogeneous distribution. We show that in such a case, genetic differentiation can be predicted at equilibrium by circuit theory, where conductance corresponds to abundance in species distribution models (SDM). Circuit-SDM approach was used for the phylogeographic study of the lepidopteran cereal stemborer Busseola fusca Füller (Noctuidae) across sub-Saharan Africa. Species abundance was surveyed across its distribution range. SDM models were optimized and selected by cross validation. Relationship between observed matrices of genetic differentiation between individuals, and matrices of resistance distance was assessed through Mantel tests and redundancy discriminant analyses (RDA). A total of 628 individuals from 130 localities in 17 countries were genotyped at 7 microsatellite loci. Six population clusters were found based on a Bayesian analysis. The eastern margin of Dahomey Gap between East and West Africa was the main factor of genetic differentiation. The SDM projections at present, last interglacial and last glacial maximum periods were used for estimation of circuit resistance between locations of genotyped individuals. For all periods of time, when using either all individuals or only East-African individuals, partial Mantel r and RDA analyses conditioning on geographic distance were found significant. Under future projections (year 2080), partial r and RDA significance were different. From this study, it is concluded that analytical solutions provided by circuit theory are useful for the evolutionary management of populations and for phylogeographic analysis when coalescence times are not accessible by approximate Bayesian simulations.
Data from: Phylogeography in continuous space: coupling species distribution models and circuit theory to assess the effect of contiguous migration at different climatic periods on genetic differentiation in Busseola fusca (Lepidoptera: Noctuidae)
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Static electric equivalent circuit of commercial lithium-ion battery cells using genetic algorithms
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A GENETIC, GENOMIC, AND COMPUTATIONAL RESOURCE FOR EXPLORING NEURAL CIRCUIT FUNCTION
GEO Series GSE116969. Drosophila melanogaster. 266 samples. Type: Expression profiling by high throughput sequencing.
Redesign of an Escherichia coli Nissle treatment for phenylketonuria using insulated genomic landing pads and genetic circuits to reduce burden
GEO Series GSE228761. Escherichia coli Nissle 1917. 96 samples. Type: Expression profiling by high throughput sequencing.
Genetic circuit 0x58 replicates and modified
GEO Series GSE98890. Escherichia coli. 19 samples. Type: Expression profiling by high throughput sequencing.
Genetic Encoding of an Esophageal Motor Circuit
GEO Series GSE202760. Mus musculus. 288 samples. Type: Expression profiling by high throughput sequencing.
Perturb-seq: Dissecting molecular circuits with scalable single cell RNA profiling of pooled genetic screens
GEO Series GSE90063. Homo sapiens; Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Genetic circuit 0x58
GEO Series GSE88835. Escherichia coli. 16 samples. Type: Expression profiling by high throughput sequencing.
Genetic circuit characterization by inferring RNA polymerase movement and ribosome usage
GEO Series GSE152664. Escherichia coli. 18 samples. Type: Expression profiling by high throughput sequencing.
Generation of highly diverse peptide library by linear-double-stranded DNA based AND gate genetic circuit in mammalian cells
GEO Series GSE134671. Homo sapiens. 18 samples. Type: Other.
A genetically defined mPFC-thalamic circuit underlies pain chronicity
GEO Series GSE243136. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Construction of Nanobody Library in Mammalian Cells by Linear-double-stranded DNA Based AND Gate Genetic Circuit
GEO Series GSE155159. Homo sapiens. 3 samples. Type: Other.
Cooperative assembly confers regulatory specificity and long-term genetic circuit stability
GEO Series GSE203146. Saccharomyces cerevisiae. 51 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Cooperative assembly confers regulatory specificity and long-term genetic circuit stability [RNA-seq]
GEO Series GSE203145. Saccharomyces cerevisiae. 19 samples. Type: Expression profiling by high throughput sequencing.
Cooperative assembly confers regulatory specificity and long-term genetic circuit stability [ChIP-Seq]
GEO Series GSE203144. Saccharomyces cerevisiae. 32 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.