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12 results for “Gilles de la Tourette syndrome”
Brain functional connectivity in chronic tic disorders and Gilles de la Tourette syndrome
<p>The pathophysiology of chronic tic disorder (cTD) and Gilles de la Tourette syndrome (GTS) is characterized by the dysfunction of both motor and non - motor cortico - striatal - thalamo - cortical (CSTC) circuitries, which leads to tic release and comorbids. A role of fronto - parietal network (FPN) connectivity breakdown has been postulated for tic pathogenesis, given that the FPN entertain connections with limbic, paralimbic, and CSTC networks. Our study was aimed at characterizing the FPN functional connectivity in cTD and GTS in order to assess the role of its deterioration in tic severity and the degree of comorbids. We recorded scalp EEG during resting state in patients with cTD and GTS. The eLORETA current source densities were analyzed, and the lagged phase synchronization (LPS) was calculated to estimate nonlinear functional connectivity between cortical areas. We found that the FPN functional connectivity in delta band was more detrimental in more severe GTS patients. Also, the sensorimotor functional connectivity in beta2 band was stronger in more severe cTD and GTS patients. FPN functional connectivity deterioration correlated with comorbids presence and severity in patients with GTS. Our data suggest that a FPN disconnection may contribute to the motoric symptomatology and comorbid severity in GTS, whereas sensorimotor disconnection may contribute to tic severity in cTD and GTS. Although preliminary, our study points out a differently disturbed brain connectivity between patients with cTD and GTS. This may serve as diagnostic marker and potentially interesting base to develop pharmacological and noninvasive neuromodulation trials aimed at reducing tic symptomatology.</p>
Pallidal Stimulation and Gilles de la Tourette Syndrome
ClinicalTrials.gov study NCT00478842. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 2: 7T MRI
ClinicalTrials.gov study NCT05233306. IPD Sharing: UNDECIDED. Countries: 1. Publications: 19.
Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 1: Simultaneous PET and 3T MRI
ClinicalTrials.gov study NCT05232955. IPD Sharing: UNDECIDED. Countries: 1. Publications: 19.
Cognitive and Brain Development in Adolescents With Gilles de la Tourette Syndrome
ClinicalTrials.gov study NCT04179435. IPD Sharing: NO. Countries: 0. Publications: 1.
Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome
ClinicalTrials.gov study NCT00664300. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Role of Frontal Cortex in the Pathophysiology of Gilles de la Tourette Syndrome (GTS)
ClinicalTrials.gov study NCT03604510. IPD Sharing: NO. Countries: 1. Publications: 0.
Gilles de la Tourette Syndrome (TS) and Seasonality
ClinicalTrials.gov study NCT04076852. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impulse Control in Gilles de la Tourette Syndrome
ClinicalTrials.gov study NCT04197804. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Repetitive Transcranial Magnetic Stimulation of the Posterior Parietal Cortex in Patients Suffering From Gilles de la Tourette Syndrome
ClinicalTrials.gov study NCT01043549. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dataset related to article "Automatic imitation in youngsters with Gilles de la Tourette syndrome: A behavioral study"
<p>dataset related to article mentioned at title</p>
Voluntary tic suppression and the normalization of motor cortical beta power in Gilles de la Tourette syndrome: an EEG study
<p>Gilles de la Tourette syndrome (GTS) is a neurological condition characterized by motor and vocal tics. Previous studies suggested that this syndrome is associated with abnormal sensorimotor cortex activity at rest, as well as during the execution of voluntary movements. It has been hypothesized that this abnormality might be interpreted as a form of increased tonic inhibition, probably to suppress tics; how- ever, this hypothesis has not been tested so far. The present study was designed to formally test how voluntary tic suppression in GTS influences the activity of the sensorimotor cortex during the execution of a motor task. We used EEG to record neural activity over the contralateral sensorimotor cortex during a finger movement task in adult GTS patients, in both free ticcing and tic suppression conditions; these data were then compared with those collected during the same task in age‐matched healthy subjects. We focused on the levels of activity in the beta frequency band, which is typically associated with the activation of the motor system, during three different phases: a pre‐movement, a movement, and a post‐movement phase. GTS patients showed decreased levels of beta modulation with respect to the healthy con- trols, during the execution of the task; however, this abnormal pattern returned to be normal when they were explicitly asked to suppress their tics while moving. This is the first demonstration that voluntary tic suppression in GTS operates through the normalization of the EEG rhythm in the beta frequency range during the execution of a voluntary finger movement.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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