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568 results for “Glucose metabolism”
Data from: "Non-metabolizable" glucose analogue shines new light on priming mechanisms: Triggering of microbial metabolism
<p>Raw data for the article:</p> <p>Kyle Mason-Jones*, Yakov Kuzyakov (2017)<br> “Non-metabolizable” glucose analogue shines new light on priming mechanisms: Triggering of microbial metabolism</p> <p>Soil Biology and Biochemistry 107, 68-76</p> <p>https://doi.org/10.1016/j.soilbio.2016.12.015</p> <p>* corresponding author: kmasonj@gwdg.de</p>
Glucose-1-phosphate metabolism (Saccharomyces cerevisiae)
<p>The glucose-1-phosphate metabolism pathway in Saccharomyces cerevisiae from 2017</p>
Effects of Pioglitazone on Insulin and Glucose Metabolism in Women With Polycystic Ovary Syndrome (PCOS)
ClinicalTrials.gov study NCT00868140. IPD Sharing: NO. Countries: 2. Publications: 1.
Photoreceptor glucose metabolism determines normal retinal vascular growth
<p>The neural cells and factors determining normal vascular growth are not well defined even though vision-threatening neovessel growth, a major cause of blindness in retinopathy of prematurity (ROP) (and diabetic retinopathy), is driven by delayed normal vascular growth. We examined if hyperglycemia and low adiponectin (APN) levels delayed normal retinal vascularization, driven primarily by dysregulated photoreceptor metabolism.</p> <p>One part of the experiments was to use targeted quantitative proteomics to measure the expression of proteins with selected reaction monitoring. We measured the enzymes in glycolysis, the Krebs cycle, and several addition mitochondrial proteins.</p> <p>We found that in a neonatal mouse model of postnatal hyperglycemia modeling early ROP, hyperglycemia caused photoreceptor dysfunction and delayed neurovascular maturation associated with changes in the APN pathway; recombinant mouse APN or APN receptor agonist adipoRon treatment normalized vascular growth. APN deficiency decreased retinal mitochondrial metabolic enzyme levels particularly in photoreceptors, suppressed retinal vascular development and decreased photoreceptor platelet-derived growth factor (Pdgfb). APN pathway activation reversed these effects. Blockade of mitochondrial respiration abolished adipoRon-induced Pdgfb increase in photoreceptors. Photoreceptor-knockdown of Pdgfb delayed retinal vascular formation. Stimulation of the APN pathway might prevent hyperglycemia-associated retinal abnormalities andsuppress Phase I ROP in premature infants.</p>
Glycerol suppresses glucose consumption in trypanosomes through metabolic contest
<p>The file contains all the source data presented in the manuscript:</p> <p>Allmann S., M. Wargnies, E. Cahoreau, M. Biran, N. Plazolles, P. Morand, E. Pineda, H. Kulyk-Babier, C. Asencio, O. Villafraz, L. Rivière, E. Tetaud, B. Rotureau, A. Mourier, J.-C. Portais, & F. Bringaud (<strong>2021</strong>) Glycerol suppresses glucose consumption in Trypanosomes through metabolic contest. <strong><em>PLoS</em></strong> <strong><em>Biol</em></strong>.</p>
Sirtuin3 ensures the metabolic plasticity of neurotransmission during glucose deprivation
<p>Neurotransmission is an energetically expensive process that underlies cognition. During intense electrical activity or dietary restrictions, glucose levels in the brain plummet, forcing neurons to utilize alternative fuels. However, the molecular mechanisms of neuronal metabolic plasticity remain poorly understood. Here, we demonstrate that glucose-deprived neurons activate the CREB and PGC1α transcriptional program that induces the expression of the mitochondrial deacetylase Sirtuin 3 (Sirt3) both <em>in vitro</em> and i<em>n vivo</em>. We show that Sirt3 localizes to axonal mitochondria and stimulates mitochondrial oxidative capacity in hippocampal nerve terminals. Sirt3 plays an essential role in sustaining synaptic transmission in the absence of glucose by powering the retrieval of synaptic vesicles after release. These results demonstrate that the transcriptional induction of Sirt3 ensures the metabolic plasticity of synaptic transmission.</p>
Chronic hyperadiponectinemia induced by transgenic overexpression increases plasma exosomes without significantly improving glucose and lipid metabolism
<p><span>The fat</span><span>-derived factor, adiponectin, is considered a salutary circulating factor.</span> <span>We recently demonstrated that native adiponectin binds T-cadherin and promotes intracellular biogenesis and secretion of the exosome. Exosomes play important roles in various aspects of homeostasis, including glucose and energy metabolism. However, it remains unclear whether and how the promotion of exosome production by adiponectin <em>in vivo</em> is beneficial for glucose and lipid metabolism. In the present study, overexpression of human adiponectin in mice resulted in an increased number of circulating exosomes, but it did not significantly improve glucose metabolism, change body weights, or change triglyceride clearance under a high-fat diet. Multiple small doses of streptozotocin increased blood glucose and decreased triglyceride clearance similarly in both wild-type and transgenic mice. Thus, these results indicated that human adiponectin overexpression in mice increases plasma exosomes but does not significantly influence glucose and lipid metabolism.</span></p>
Central Mechanisms That Regulate Glucose Metabolism in Humans
ClinicalTrials.gov study NCT01028846. IPD Sharing: NO. Countries: 1. Publications: 1.
Thyroid and Glucose and Energy Metabolism
ClinicalTrials.gov study NCT00106119. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Exercise Training and Glucose Metabolism in Aging
ClinicalTrials.gov study NCT00701051. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Welchol on Glucose Metabolism in Type 2 Diabetics
ClinicalTrials.gov study NCT00951899. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Intermittent Calorie Restriction on MASLD Patients With Abnormal Glucose Metabolism
ClinicalTrials.gov study NCT04283942. IPD Sharing: NO. Countries: 1. Publications: 17.
Acute Effects of Coffee on Appetite and Inflammation Markers, Glucose Metabolism and Energy Intake
ClinicalTrials.gov study NCT01174576. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Rosiglitazone for Clozapine Induced Glucose Metabolism Impairment
ClinicalTrials.gov study NCT00337350. IPD Sharing: Not stated. Countries: 1. Publications: 24.
Acute Effect of Exenatide on Brain Glucose Metabolism
ClinicalTrials.gov study NCT01588418. IPD Sharing: NO. Countries: 1. Publications: 2.
Post-Prandial Liver Glucose Metabolism in PCOS
ClinicalTrials.gov study NCT03041129. IPD Sharing: NO. Countries: 1. Publications: 1.
Sleep Loss and Mechanisms of Impaired Glucose Metabolism
ClinicalTrials.gov study NCT00555750. IPD Sharing: Not stated. Countries: 1. Publications: 17.
The Effects of Potassium on Glucose Metabolism in African Americans
ClinicalTrials.gov study NCT02236598. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Probiotic Impact on Cognitive Performance, and Metabolic Outcomes in Overweight Young Adults With Impaired Glucose Regulation
ClinicalTrials.gov study NCT07073781. IPD Sharing: YES. Countries: 1. Publications: 14.
Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism
ClinicalTrials.gov study NCT01503164. IPD Sharing: Not stated. Countries: 1. Publications: 5.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.