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84 results for “HNF4A”
Data from: High-throughput mRNA sequencing-based DEGs: HNF4A mitigates sepsis-associated lung injury by upregulating NCOR2/GR/STAB1 axis and promoting macrophage polarization towards M2 phenotype
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Data from: Frequency and characteristics of MODY 1 (HNF4A mutation) and MODY 5 (HNF1B mutation) - Analysis from the DPV database
Objective. To characterize initial presentation and clinical course of patients with hepatocyte nuclear factor (HNF) 4A- and HNF1B-MODY in a multinational registry. Design, setting and participants. Within the Diabetes Patienten Verlaufsdokumentation (DPV) registry, 44 patients with HNF4A- and 35 patients with HNF1B-MODY were characterized and compared with patients < 20years old with type 1 diabetes (T1D)/type 2 diabetes (T2D). Main outcome measure. Clinical and laboratory parameters, therapy, metabolic control, and extrapancreatic symptoms in patients with HNF1B-MODY. Results. Patients with both MODY types were significantly older than T1D patients at diagnosis (HNF4A, 13.8 years and HNF1B, 13.5 years, vs. T1D, 8.8 years, P<0.0001). Mean C-peptide at diagnosis was higher for HNF4A-MODY than for T1D (1.8 vs. 0.9 ng/ml, P <0.01). 36.4% of patients with HNF4A-MODY and 65.7% of patients with HNF1B-MODY were treated with insulin, 20.5% and 8.6% received oral antidiabetics only (p<0.05 and p<0.01 vs. T2D). At the most recent visit, glycated hemoglobin levels were lower in HNF4A- and HNF1B-MODY compared to T1D (mean, 6.5% and 6.1%) than in T1D. In 40% of patients with HNF1B-MODY, extrapancreatic symptoms were reported. Several clinical predictors previously described to differentiate between MODY and T1D or T2D could be revalidated by logistic regression analyses in this cohort.Conclusion The DPV registry enabled us to precisely characterize phenotype and treatment in these two rare MODY types. Although phenotype of HNF4A-and HNF1B-MODY shows distinct differences to T1D and T2D, 38% of patients were initially misclassified as having T1D or T2D.
Data from: TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation
The functions of the TAF subunits of mammalian TFIID in physiological processes remain poorly characterised. Here we describe a novel function of TAFs in directing genomic occupancy of a transcriptional activator. Using liver-specific inactivation in mice, we show that the TAF4 subunit of TFIID is required for post-natal hepatocyte maturation. TAF4 promotes pre-initiation complex (PIC) formation at post-natal expressed liver function genes and down-regulates a subset of embryonic expressed genes by increased RNA polymerase II pausing. The TAF4-TAF12 heterodimer interacts directly with HNF4A and in vivo TAF4 is necessary to maintain HNF4A-directed embryonic gene expression at post-natal stages and promotes HNF4A occupancy of functional cis-regulatory elements adjacent to the transcription start sites of post-natal expressed genes. Stable HNF4A occupancy of these regulatory elements requires TAF4-dependent PIC formation highlighting that these are mutually dependent events. Local promoter-proximal HNF4A-TFIID interactions therefore act as instructive signals for post-natal hepatocyte differentiation.
Comprehensive characterization of HNF4A and HNF1A genomic targets in pancreatic beta cells and hepatic cells reveals common and tissue-specific gene regulation
<p>Molecular dynamics simulation input files, initial and final coordinate files</p>
Data from: TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation
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Data from: Frequency and characteristics of MODY 1 (HNF4A mutation) and MODY 5 (HNF1B mutation) - Analysis from the DPV database
Open the record for dataset details and reuse information.
Hnf4a chromatin interactions in PDAC [ChIP-seq]
GEO Series GSE138452. Mus musculus. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
HNF4A regulation of transcription profiles in the mouse ileal and colonic epithelial cells
GEO Series GSE199416. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Bulk RNA-seq of wild type, HNF4A-knockout (KO), HNF4G-KO, and HNF4A/4G-double KO (DKO) kidney organoids
GEO Series GSE226439. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Hnf4a regulated transcriptome in organoid cultures derived from murine pancreas where HNnf4a is deleted after tumor initiation. [organoid]
GEO Series GSE138142. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Effects of overexpressing HNF4A on 3D cultured mouse and human colon organoid
GEO Series GSE245288. Homo sapiens; Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
HNF4A regulation of transcription profiles in the mouse cecal epithelial cells
GEO Series GSE199415. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells
GEO Series GSE188827. Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing.
[E-MTAB-115] ChIP-seq for FOXA2 HNF4a and NRF2 / GABP in HepG2
GEO Series GSE25694. Homo sapiens. 11 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Changes in chromatin accessibility landscape induced by Hnf4a in PDAC [ATAC-seq]
GEO Series GSE138451. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Extrahepatic tumors induce inflammation causing liver depletion of HNF4a and driving a systemic metabolic rewiring II
GEO Series GSE223835. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Therapeutic delivery of transcription factor HNF4A mRNA attenuates liver fibrosis
GEO Series GSE165277. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
HNF4A-binding sites in HepG2 hepatoblastoma cells treated with TGF-beta
GEO Series GSE28845. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Transcription Factors GATA4 and HNF4A Control Distinct Aspects of Intestinal Homeostasis in Conjunction With the Transcription Factor CDX2
GEO Series GSE62633. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
A critical role for Hepatocyte Nuclear Factor 4 alpha in polymicrobial sepsis-associated metabolic reprogramming and death: effect of IL6 in Hnf4a WT and KO mice
GEO Series GSE246053. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.