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125 results for “HSV-1”
Data from: A CRISPR-based rapid DNA repositioning strategy and the early intranuclear life of HSV-1
<p>The relative positions of viral DNA genomes to the host intranuclear environment play critical roles in determining virus fate. Recent advances in the application of chromosome conformation capture-based sequencing analysis (3C technologies) have revealed valuable aspects of the spatiotemporal interplay of viral genomes with host chromosomes. However, to elucidate the causal relationship between the subnuclear localization of viral genomes and the pathogenic outcome of an infection, manipulative tools are needed. Rapid repositioning of viral DNAs to specific subnuclear compartments amid infection is a powerful approach to synchronize and interrogate this dynamically changing process in space and time. Herein, we report an inducible CRISPR-based two-component platform that relocates extrachromosomal DNA pieces (5 kb to 170 kb) to the <strong>nu</strong>clear <strong>p</strong>eriphery <strong>in</strong> minutes (CRISPR-nuPin). Based on this strategy, investigations of herpes simplex virus 1 (HSV-1), a prototypical member of the human herpesvirus family, revealed unprecedently reported insights into the early intranuclear life of the pathogen: I) Viral genomes tethered to the nuclear periphery upon entry, compared with those freely infecting the nucleus, were wrapped around histones with increased suppressive modifications and subjected to stronger transcriptional silencing and prominent growth inhibition. II) Relocating HSV-1 genomes at 1 hour post infection significantly promoted the transcription of viral genes, termed an "Escaping" effect. III) Early accumulation of ICP0 was a sufficient but not necessary condition for "Escaping". IV) Subnuclear localization was only critical during early infection. Importantly, the CRISPR-nuPin tactic, in principle, is applicable to many other DNA viruses.</p>
Valacyclovir vs. Acyclovir as HSV-2 Suppressive Therapy: Effect on Plasma HIV-1 Levels Among HIV-1/HSV-2 Co-infected Persons
ClinicalTrials.gov study NCT01026454. IPD Sharing: Not stated. Countries: 1. Publications: 4.
HSV-2 Suppression to Reduce Maternal HIV-1 RNA Levels During Pregnancy and Breastfeeding
ClinicalTrials.gov study NCT00530777. IPD Sharing: Not stated. Countries: 1. Publications: 24.
Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1)
ClinicalTrials.gov study NCT03661541. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: A CRISPR-based rapid DNA repositioning strategy and the early intranuclear life of HSV-1
Open the record for dataset details and reuse information.
BX-795 inhibits HSV-1 and HSV-2 replication in a JNK/p38-dependent manner, but not through interfering PDK1 activity
<p>The two files contain the methods and result data of submitted paper, <em>BX-795 inhibits HSV-1 and HSV-2 replication in a JNK/p38-dependent manner, but not through interfering PDK1 activity.</em></p>
Mapped ATAC-seq data for mock and HSV-1 strain 17 infection and infection with null mutants of HSV-1
<p>Sample annotation:</p> <table> <tbody> <tr> <td>Mock_1</td> <td>mock infection, replicate 1</td> </tr> <tr> <td>Mock_2</td> <td>mock infection, replicate 2</td> </tr> <tr> <td>WT_1</td> <td>HSV-1 wt, strain 17, replicate 1</td> </tr> <tr> <td>WT_2</td> <td>HSV-1 wt, strain 17, replicate 2</td> </tr> <tr> <td>WT_plus_PAA_1</td> <td>HSV-1 wt, strain 17, +PAA, replicate 1</td> </tr> <tr> <td>WT_plus_PAA_2</td> <td>HSV-1 wt, strain 17, +PAA, replicate 2</td> </tr> <tr> <td>dICP0_1</td> <td>HSV-1 lacking expression of ICP0, replicate 1</td> </tr> <tr> <td>dICP0_2</td> <td>HSV-1 lacking expression of ICP0, replicate 2</td> </tr> <tr> <td>dICP22_1</td> <td>HSV-1 lacking expression of ICP22, HSV-1 strain F mutant R325, replicate 1</td> </tr> <tr> <td>dICP22_2</td> <td>HSV-1 lacking expression of ICP22, HSV-1 strain F mutant R325, replicate 2</td> </tr> <tr> <td>dICP22_3</td> <td>HSV-1 lacking expression of ICP22, HSV-1 strain F mutant R325, replicate 3</td> </tr> <tr> <td>dICP22_4</td> <td>HSV-1 lacking expression of ICP22, HSV-1 strain F mutant R325, replicate 4</td> </tr> <tr> <td>dICP22_plus_PAA_1</td> <td>HSV-1 lacking expression of ICP22, HSV-1 strain F mutant R325, +PAA, replicate 1</td> </tr> <tr> <td>dICP22_plus_PAA_2</td> <td>HSV-1 lacking expression of ICP22, HSV-1 strain F mutant R325, +PAA, replicate 2</td> </tr> <tr> <td>dICP27_1</td> <td>HSV-1 lacking expression of ICP27, KOS, replicate 1</td> </tr> <tr> <td>dICP27_2</td> <td>HSV-1 lacking expression of ICP27, KOS, replicate 2</td> </tr> <tr> <td>dVHS_1</td> <td>HSV-1 lacking expression of UL41, replicate 1</td> </tr> <tr> <td>dVHS_2</td> <td>HSV-1 lacking expression of UL41, replicate 2</td> </tr> </tbody> </table>
Fibromyalgia Outcome Research Trial Evaluating Synergistic Suppression of HSV-1
ClinicalTrials.gov study NCT04748705. IPD Sharing: NO. Countries: 1. Publications: 1.
Acyclovir in Ventilated Patients With Pneumonia and HSV-1 in BAL
ClinicalTrials.gov study NCT06134492. IPD Sharing: YES. Countries: 1. Publications: 1.
HSV-2 Suppression to Reduce HIV-1 Levels in HIV-1 Co-infected Persons
ClinicalTrials.gov study NCT00465205. IPD Sharing: Not stated. Countries: 1. Publications: 1.
HSV-2 Suppression to Reduce HIV-1 Levels in HIV-1, HSV-2 Co-infected Men.
ClinicalTrials.gov study NCT00378976. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Safety and Effectiveness of Tenofovir Gel in the Prevention of Human Immunodeficiency Virus (HIV-1) Infection in Women and the Effects of Tenofovir Gel on the Incidence of Herpes Simplex Virus (HSV-2)
ClinicalTrials.gov study NCT01386294. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Genetically Engineered HSV-1 Phase 1 Study for the Treatment of Recurrent Malignant Glioma
ClinicalTrials.gov study NCT02062827. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Ribosome profiling of HSV-1 infected cells
GEO Series GSE128322. Human alphaherpesvirus 1 strain 17; Homo sapiens. 10 samples. Type: Other.
Wide-spread disruption of transcription termination in HSV-1 infection: Next generation sequencing of total and newly transcribed (4sU-RNA) RNA from different virus strains and mutant viruses
GEO Series GSE151912. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
RPSA and proinflammatory cytokines after HSV-1 infection
GEO Series GSE204895. Mus musculus. 29 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
The HSV-1 ICP22 protein selectively impairs histone repositioning upon Pol II transcription downstream of genes (RNA-seq II)
GEO Series GSE208078. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Chromatin-associated RNA of HSV-1 infected primary human fibroblasts including infection with vhs mutants
GEO Series GSE140068. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Transcription start site profiling of HSV-1 infected cells using cRNA-seq and dRNA-seq
GEO Series GSE128323. Homo sapiens; Human alphaherpesvirus 1 strain 17. 18 samples. Type: Other.
Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells
GEO Series GSE40593. Homo sapiens. 18 samples. Type: Expression profiling by array.
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OpenNeuro
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