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146 results for “High glucose”
Clinical evidence for high-risk CE-marked medical devices for glucose management: a systematic review and meta-analysis
<p><strong><span>Aims: </span></strong><span>High-risk medical devices are increasingly used in diabetes management, but<span><span> there are no specific European recommendations on how they should be evaluated. Within</span></span> the Coordinating Research and Evidence for Medical Devices (CORE-MD) project, we conducted a systematic review and meta-analysis evaluating CE-marked high-risk devices for glucose management. </span></p> <p><strong><span>Materials and Methods: </span></strong><span>We<span> identified interventional and observational studies evaluating the </span>efficacy and safety of 8 automated insulin delivery (AID) systems, 2 implantable insulin pumps, and 3 implantable continuous glucose monitoring (CGM) devices.<span> </span></span><span>We meta-analysed randomized controlled trials (RCTs) comparing AID systems with other treatments.</span></p> <p><strong><span>Results:</span></strong><span> 99 studies published from 2009–2022 were included, comprising 83 on AID systems, 6 on insulin pumps, and 10 on CGM; 43% reported industry funding;30% were pre-market; 45% had a comparator group. 33% were RCTs, 25% non-randomized trials, and 41% observational studies. Median sample size was 52 (interquartile range 25–111), age 37.8 years (17–45.5), and study duration 13 weeks (4.5–26). AID systems lowered HbA1c by 0.3 percentage points (absolute mean difference [MD]=-0.3; 9 RCTs; I<sup>2</sup>=85%) and increased time in target range for sensor glucose level by 10.5 percentage points (MD=10.5; 14 RCTs; I<sup>2</sup>=89%). 69% of studies reported on at least one safety outcome.</span></p> <p><strong><span>Conclusions:</span></strong><span> High-risk devices for glucose monitoring or insulin dosing, in particular AID systems, improve glucose control safely but evidence on diabetes-related end organ damage is lacking due to short study durations. Methodological heterogeneity highlights the need for d<span><span>eveloping standards for future pre- and post-market investigations of diabetes-specific high-risk medical devices.</span></span></span></p>
Managing Type 1 and High Risk Type 2 Diabetes in the Hospital Setting: Glucose as a Vital Sign
ClinicalTrials.gov study NCT03068273. IPD Sharing: NO. Countries: 1. Publications: 1.
Figure S1-S3: The ARPE-19 cells were cultured in low glucose (5 mM), osmotic Control and high glucose (25 mM) medium.
<p><span>Figure S1-S3: The ARPE-19 cells were cultured in low glucose (5 mM), osmotic Control and high glucose (25 mM) medium.</span></p>
The effect of dietary supplementation with blueberry, cyanidin-3-O-β-glucoside, yoghurt and its peptides on gene expression associated with glucose metabolism in skeletal muscle obtained from a high-fat-high-carbohydrate diet induced obesity model
<p><span>Obesity is a leading global health problem contributing to various chronic diseases, including type II diabetes mellitus</span> <span>(T2DM). The aim of this study was to investigate whether blueberries, yoghurt, and their respective bioactive components, Cyanidin-3-O-β-glucoside (C3G) and peptides alone or in combinations, alter the expression of genes related to glucose metabolism in skeletal muscles from diet-induced obese mice. In extensor digitorum longus (EDL), yoghurt up-regulated the expression of activation of 5'adenosine monophosphate-activated protein kinase (AMPK), insulin receptor substrate-1 (IRS-1), phosphatidylinositol-3 kinase (PI3K) and glucose transporter 4 (GLUT4), and down-regulated the expression of angiotensin II receptor type 1 (AGTR-1). The combination of blueberries and yoghurt down-regulated the mRNA expression of AGTR-1 and Forkhead box protein O1 (FoxO1) in the EDL. Whereas the combination of C3G and peptides down-regulated AGTR-1 and up-regulated GLUT4 mRNA expression in the EDL. In the soleus, blueberries and yoghurt alone, and their combination down-regulated AGTR-1 and up-regulated GLUT4 mRNA expression. In summary blueberries and yoghurt, regulated multiple genes associated with glucose metabolism in skeletal muscles, and therefore may play a role in the management and prevention of T2DM.</span></p>
Multi-omics analysis reveals attenuation of cellular stress by Empagliflozin in High Glucose-treated human cardiomyocytes.
<p>Mass spectrometry raw data for the manuscript <strong>Multi-omics analysis reveals attenuation of cellular stress by Empagliflozin in High Glucose-treated human cardiomyocytes.</strong></p>
Fig. 8 in Structurally diverse polycyclic polyprenylated acylphloroglucinols with protective effect on human vein endothelial cells injured by high-glucose from Hypericum acmosepalum N. Robson
Fig. 8. Screening results of protective effect of compounds 1–4, and 7–16 at 50 μg/mL on HUVECs injured by high-glucose, using 0.1 mmol/L aspirin as the positive control. *P <0.01 compared with the control group; **P <0.01 compared with the model group, respectively.
Fig. 9 in Structurally diverse polycyclic polyprenylated acylphloroglucinols with protective effect on human vein endothelial cells injured by high-glucose from Hypericum acmosepalum N. Robson
Fig. 9. The HUVECs morphologies of Control (A), Model (B), Positive Control (C), and sample groups at 1 (D), 5 (E), 50 (F) μg/mL of compound 13.
High-intensity Interval Exercise and Chocolate Milk on Blood Glucose and Cognition
ClinicalTrials.gov study NCT03305107. IPD Sharing: NO. Countries: 1. Publications: 1.
Therapies on Newly Diagnosed Type 2 Diabetes Patients With High Glucose Toxicity Which Protect Islet β Cell
ClinicalTrials.gov study NCT03180281. IPD Sharing: NO. Countries: 1. Publications: 1.
DAPAgliflozin Sodium Water glucosE EffecTs in Patients at High Cardiovascular Risk
ClinicalTrials.gov study NCT04258371. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Blood Pressure and Glucose Lowering for the Prevention of Vascular Disease in High Risk Patients With Type 2 Diabetes
ClinicalTrials.gov study NCT00145925. IPD Sharing: Not stated. Countries: 5. Publications: 50.
Effect of a Low-calorie and High-protein Diet Specially Rich in Animal Protein Compared to a Low-calorie and High-protein Diet Specially Rich in Plant Protein on Glucose Metabolism in Subjects With Pr
ClinicalTrials.gov study NCT05456347. IPD Sharing: NO. Countries: 1. Publications: 1.
The Metabolic Effects of a High Fructose Versus a High Glucose Diet in Overweight Men
ClinicalTrials.gov study NCT01050140. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of High-dose Pitavastatin on Glucose Control in Patients With Metabolic Syndrome
ClinicalTrials.gov study NCT02940366. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Comparison of the Metabolic Effects of Fructose, Glucose, High Fructose Corn Syrup and Sucrose at Normal Population Consumed Levels in Adults Aged 20-60 Years Old
ClinicalTrials.gov study NCT01797042. IPD Sharing: Not stated. Countries: 1. Publications: 1.
First Trimester Glycosylated Haemoglobin Und Plasma Glucose in Women at High Risk for Gestational Diabetes
ClinicalTrials.gov study NCT02139254. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Real-Time Continuous Glucose Monitoring (RT-CGM) in Patients With Type 1 Diabetes at High Risk for Low Glucose Values Using Multiple Daily Injections (MDI) in Germany (HYPODE-STUDY)
ClinicalTrials.gov study NCT02671968. IPD Sharing: Not stated. Countries: 1. Publications: 4.
The effect of dietary supplementation with blueberry, cyanidin-3-O-β-glucoside, yoghurt and its peptides on gene expression associated with glucose metabolism in skeletal muscle obtained from a high-fat-high-carbohydrate diet induced obesity model
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High Glucose Regulates the Cellular Dysfunction of Human Trophoblast HTR8/SVneo Cells by Downregulating GABRP Expression
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Fig. 5 in Structurally diverse polycyclic polyprenylated acylphloroglucinols with protective effect on human vein endothelial cells injured by high-glucose from Hypericum acmosepalum N. Robson
Fig. 5. Experimental and calculated ECD spectra of 4.
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International Brain Laboratory public data
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OpenNeuro
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