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Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus
<p>This is supplementary data and source data for the manuscript, <em>"Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus"</em>.</p> <p><strong>Abstract</strong>: Schizophrenia is a complex neuropsychiatric disorder with sexually dimorphic features, including differential symptomatology, drug responsiveness, and male incidence rate. Prior large-scale transcriptome analyses for sex differences in schizophrenia have focused on the prefrontal cortex. Analyzing BrainSeq Consortium data (caudate nucleus: n=399, dorsolateral prefrontal cortex: n=377, and hippocampus: n=394), we identified 831 unique genes that exhibit sex differences across brain regions, enriched for immune-related pathways. We observed X-chromosome dosage reduction in the hippocampus of male individuals with schizophrenia. Our sex interaction model revealed 148 junctions dysregulated in a sex-specific manner in schizophrenia. Sex-specific schizophrenia analysis identified dozens of differentially expressed genes, notably enriched in immune-related pathways. Finally, our sex-interacting expression quantitative trait loci analysis revealed 704 unique genes, nine associated with schizophrenia risk. These findings emphasize the importance of sex-informed analysis of sexually dimorphic traits, inform personalized therapeutic strategies in schizophrenia, and highlight the need for increased female samples for schizophrenia analyses.</p>
Data associated with "A weakened recurrent circuit in the hippocampus of Rett syndrome mice disrupts long-term memory representations"
<p><strong>Datasets used in <em>A weakened recurrent circuit in the hippocampus of Rett syndrome mice disrupts long-term memory representations.</em></strong></p> <p><strong>Datatypes:</strong></p> <ol> <li>Multi-index pandas dataframe (.pkl)</li> <li>Numpy array (.npy)</li> <li>Collection of numpy arrays (.npz)</li> <li>Python dictionary objects (.pkl)</li> </ol> <p><strong>Datasets:</strong></p> <p><strong>alignments.pkl: A dataframe containing numpy arrays of image displacements for each mouse in each memory context.</strong></p> <p>This multi-index dataframe has rows indexed by genotype ('wt' or 'het') and mouse_id. The columns are ['T', 'F1', 'N1', 'F2', 'N2'] for the training, recall 1-hour, neutral, recall 1-day, neutral day 2 memory contexts respectively. Each element of this dataframe is a numpy array of shape images x 2 that hold x and y image displacements respectively. These alignments are computed after the inscopix software motion correction and are used in Supplemental Figure 2 of the paper.</p> <p><strong>behavior_df.pkl: A dataframe of behavior readouts recorded by a camera positioned above the mice in each context chamber.</strong></p> <p>This multi-index dataframe has rows indexed by genotype ('wt' or 'het') and mouse_id.The columns are; sample times (*_time), freezing boolean arrays (*_freeze), x-positions in context chamber (*_x) and y-positions in the context chamber (*_y) for each context (*) in ('Train', 'Fear', 'Neutral', 'Fear_2', 'Neutral_2').</p> <p><strong>correlated_pairs_df.pkl: A dataframe containing arrays of neuron indices that have a correlation in activity pattern > 0.3.</strong></p> <p>This multi-index dataframe has rows indexed by genotype ('wt' or 'het') and mouse_id and treatment ('NA'). The columns contain ['Train', 'Fear', 'Neutral', 'Fear_2', 'Neutral_2'] representing each memory context. Each element of the dataframe is a numpy array with three columns. The first two columns are the neuron indices that are correlated and the last column is the strength of the correlation.</p> <p><strong>dredd_freezes_df.pkl: A dataframe containing freezing percentages for SOM-Cre and RTT-SOM-Cre mice treated with DREADDS.</strong></p> <p>This multi-index dataframe has rows indexed by genotype ('wt' or 'het') and mouse_id and treatment (mcherry, hm3d, hm4d). The columns contain one of ['Neutral', 'Fear', 'Fear_2']. Each element of the dataframe is a freezing percentage for a single mouse. This dataframe is built from reading the dredd_behavior.xlsx excel file. This is used to generate figure 5E of the paper.</p> <p><strong>high_degree_df.pkl: A dataframe containing list of high degree neuron indices.</strong></p> <p>This multi-index dataframe has rows indexed by genotype ('wt' or 'het') and mouse_id and treatment ('NA'=not applicable since no DREADD used). The columns contain ['Train', 'Fear', 'Neutral', 'Fear_2', 'Neutral_2'] representing each memory context. Each element of the dataframe is a list of neuron indices that are high-degree cells.</p> <p><strong>N006_wt_basis.npz: a dict containing three numpy arrays representing the basis images for mouse N006 of genotype wild-type.</strong></p> <p>This dict has three arrays stored under the variable names 'U', 'sigma' and 'img_shape'. U is a matrix of column vector basis images. Each column is the vector representation of a basis image (row pixels x column pixels). There are 220 basis images (columns) in U. The sigma variable is the singular value associated with each basis image vector in U. img_shape can be used to reshape each basis column vector into a 2-D image for viewing. This data is used in Supplemental Figure 2 of the paper.</p> <p><strong>N006_wt_cxtbasis.pkl: A dictionary containing arrays for basis images and singular values for each context.</strong></p> <p>This dictionary has keys, ['Train', 'Fear', 'Neutral', 'Fear_2', 'Neutral_2'] representing the memory contexts. Each value is a 2 element list containing the U-basis images as column vectors and singular values, one per basis image in U. The shape of the basis images is the same shape stored in N006_wt_basis.pkl. This dataset is used in Supplementary Figure 2 to track cells across contexts of the CFC task (see also N006_wt_cxtsources.pkl)</p> <p><strong>N006_wt_cxtsources.pkl: A dictionary containing the independent component source images computed from the basis images for automatically identifying regions of interest (ROIs). </strong></p> <p>The dictionary is keyed on ['Train', 'Fear', 'Neutral', 'Fear_2', 'Neutral_2'] contexts. Each value in the dictionary at a given key is a 3-D numpy array of shape sources x height x width. These data were used to construct the source images and max intensity projection image of the sources in Supplemental Figure 2F-J of the paper.</p> <p><strong>N006_wt_rois.pkl: A dictionary containing the boundaries and annuli coordinates of all rois for mouse N006 of genotype wild-type.</strong></p> <p>This dictionary is keyed on ['boundaries', 'annuli'] contexts and each value is a 179 element list of arrays of boundary line coordinates or annulus point coordinates one per ROI detected for this mouse.</p> <p><strong>N006_wt_sources.npy: A numpy array containing all source images computed from all contexts of the CFC task for mouse N006 of genotype wild-type.</strong></p> <p>This numpy array has shape n x height x width where n=205 source images, height=517 pixels and width=704 pixels. This data was used to construct Supplemental Figure 3F.</p> <p><strong>N019_wt_basis.npz: a dict containing three numpy arrays representing the basis images for mouse N019 of genotype wild-type.</strong></p> <p>This dict has three arrays stored under the variable names 'U', 'sigma' and 'img_shape'. U is a matrix of column vector basis images. Each column is the vector representation of a basis image (row pixels x column pixels). There are 220 basis images (columns) in U. The sigma variable is the singular value associated with each basis image vector in U. img_shape can be used to reshape each basis column vector into a 2-D image for viewing. This data is used in Figure 1C of the paper.</p> <p><strong>N019_wt_sources.npy: A numpy array containing all source images computed from all contexts of the CFC task for mouse N019 of genotype wild-type.</strong></p> <p>This numpy array has shape n x height x width where n=204 source images, height=516 pixels and width=698 pixels. This data was used to construct Figure 1C of the paper.</p> <p><strong>P80_animals.pkl: A pandas multi-index object containing the genotype, mouse_id and treatment of the top 80% behavioral performance animals.</strong></p> <p>In this study, we drop the lowest 20% performing WT and RTT animals based on freezing percentage during the recall contexts. This multi-index is used to filter the data before each computation or plot in this study. So for example Figure 1B contains only the top 80% performing WT and RTT mice.</p> <p><strong>pc_sipscs_amps.pkl: A dictionary containing the amplitudes of spontaneous IPSCs recorded in pyramidal cells of WT and RTT mice.</strong></p> <p>This dictionary is keyed on ['wt', 'mecp2_pos', 'mecp2_neg'] representing whether the pyramidal cell was recorded from a wild-type mouse ('wt') or is an MeCP2 negative or MeCP2 positive RTT cell. This value under each key is an array of IPSC amplitudes, one per recorded cell. This data was used to construct Figure 4C in the paper.</p> <p><strong>pc_sipscs_freqs.pkl: A dictionary containing the frequencies of spontaneous IPSCs recorded in pyramidal cells of WT and RTT mice.</strong></p> <p>This dictionary is keyed on ['wt', 'mecp2_pos', 'mecp2_neg'] representing whether the pyramidal cell was recorded from a wild-type mouse ('wt') or is an MeCP2 negative or MeCP2 positive RTT cell. This value under each key is an array of IPSC frequencies, one per recorded cell. This data was used to construct Figure 4C in the paper.</p> <p><strong>rois_df.pkl: A multi-index dataframe containing all ROI information for each non-DREADD treated cell in this study (Figures 1-3).</strong></p> <p>This dataframe index contains the genotype ('wt', 'het'), the mouse_id, the treatment ('NA'=not applicable since no DREADD used), and the cell index starting from 0. The columns are ['centroid', 'cell_boundary', 'annulus_boundary']. The centroid for each cell is a 2-tuple of row, column pixel centroid coordinates. The cell_boundary is a two-column array of row, col boundary points for each ROI. The annulus_boundary is a two-column array of row, column interior points in the annulus. The annulus region excludes points of overlap with nearby cell bodies (See STAR methods of the paper).</p> <p><strong>signals_df.pkl: A multi-index dataframe containing calcium signals, inferred spikes and metadata for all Non-DREADD experiments used in this study (Figs 1-3).</strong></p> <p>This dataframe index contains the genotype ('wt', 'het'), the mouse_id, the treatment ('NA'=not applicable since no DREADD used), and the cell index starting from 0 and going up to 5771 cells. The columns are ['channels', 'channel', 'num_pages', 'width', 'height', 'bits', 'Train_signals', 'Fear_signals', 'Neutral_signals', 'Cue_signals', 'Fear_2_signals', 'Neutral_2_signals', 'Cue_2_signals', 'Train_spikes', 'Fear_spikes', 'Neutral_spikes', 'Cue_spikes', 'Fear_2_spikes', 'Neutral_2_spikes', 'Cue_2_spikes', 'sample_rate']. The channels are all the recorded channels, the channels is the channel on which ROIs were detected, the width and height are the image dimensions, the bits is the image bit depth of the calcium movie. The *_signals' are the df/f signals for each cell in each context. Each signal is a numpy array with the first 800 samples have been set to NAN due to settling time of the miniscope. The '*_spikes' are the inferred spikes for each cell stored as an image index. This signal and spike indices can be converted to time using the sample column. This dataframe is used in the construction of Figures 1-3 in the paper.</p> <p><strong>som_behavior_df.pkl: A dataframe of behavior readouts recorded by a camera positioned above the mice in each context chamber.</strong></p> <p>This multi-index dataframe has rows indexed by genotype ('wt' or 'het') and mouse_id. The columns are; sample times (*_time), freezing boolean arrays (*_freeze), x-positions in context chamber (*_x) and y-positions in the context chamber (*_y) for each context in *=('Train', 'Fear', 'Neutral', 'Fear_2', 'Neutral_2'). This dataframe was not used in the paper but may still be useful for further analysis.</p> <p><strong>som_sepsc_amplitudes:</strong> <strong>A dictionary containing the amplitudes of spontaneous EPSCs recorded in SOM cells of WT and RTT mice with and without MeCP2.</strong></p> <p>A dictionary with keys ['som', 'som_rett_pos', 'som_rett_neg'] for WT SOM and RTT-SOM cells with and without MeCP2 respectively. Each value is a list of sEPSC amplitudes. This data was used in Figure 4E-G.</p> <p><strong>som_sepsc_freqs:</strong> <strong>A dictionary containing the amplitudes of spontaneous EPSCs recorded in SOM cells of WT and RTT mice with and without MeCP2.</strong></p> <p>A dictionary with keys ['som', 'som_rett_pos', 'som_rett_neg'] for WT SOM and RTT-SOM cells with and without MeCP2 respectively. Each value is a list of sEPSC frequencies. This data was used in Figure 4E-G.</p> <p><strong>som_signals_df.pkl: A multi-index dataframe containing calcium signals, inferred spikes and metadata for all Non-DREADD SOM cell recordings used in this study (Figs 5).</strong></p> <p>This dataframe index contains the genotype ('wt', 'het'), the mouse_id, the treatment ('NA'=not applicable since no DREADD used), and the cell index starting from 0 and going up to 710 cells. The columns are ['channels', 'channel', 'num_pages', 'width', 'height', 'bits', 'Train_signals', 'Fear_signals', 'Neutral_signals', 'Cue_signals', 'Fear_2_signals', 'Neutral_2_signals', 'Cue_2_signals', 'Train_spikes', 'Fear_spikes', 'Neutral_spikes', 'Cue_spikes', 'Fear_2_spikes', 'Neutral_2_spikes', 'Cue_2_spikes', 'sample_rate']. The channels are all the recorded channels, the channels is the channel on which ROIs were detected, the width and height are the image dimensions, the bits is the image bit depth of the calcium movie. The *_signals' are the df/f signals for each cell in each context. Each signal is a numpy array with the first 800 samples have been set to NAN due to settling time of the miniscope. The '*_spikes' are the inferred spikes for each cell stored as an image index. This signal and spike indices can be converted to time using the sample column. This data was used to construct Figure 5B-C.</p> <p><strong>ssn33_sstcre_basis.npz: a dict containing three numpy arrays representing the basis images for mouse ssn33 of genotype sst-cre.</strong></p> <p>This dict has three arrays stored under the variable names 'U', 'sigma' and 'img_shape'. U is a matrix of column vector basis images. Each column is the vector representation of a basis image (row pixels x column pixels). There are 100 basis images (columns) in U. The sigma variable is the singular value associated with each basis image vector in U. img_shape can be used to reshape each basis column vector into a 2-D image for viewing. This data is used in Figure 5A of the paper.</p> <p><strong>ssn33_sstcre_sources.npy: A numpy array containing all source images computed from all contexts of the CFC task for mouse N019 of genotype wild-type.</strong></p> <p>This numpy array has shape n x height x width where n=86 source images, height=516 pixels and width=654 pixels. This data was used to construct Figure 5A of the paper.</p>
Voxel-level summary statistics of hippocampus shape, white matter microstructure, and cortical surface curvature in UK Biobank (n=33,324)
<p>This deposit hosts GWAS summary statistics of hippocampus shape (n=33,324), white matter microstructure (n=33,324), and cortical surface curvature (n=15,752) using UKB unrelated white subjects. The data was generated by using the highly efficient imaging genetics (<a href="https://github.com/Zhiwen-Owen-Jiang/heig">HEIG v1.1.0</a>) framework where only the triplets - summary statistics of low-dimensional representations (LDRs), the functional bases, and the variance-covariance matrix LDRs - are shared, which is sufficient to recover all voxel-variant pairs as well as to conduct voxel-level heritability and (cross-trait) genetic correlation analysis. Check the <a href="https://github.com/Zhiwen-Owen-Jiang/heig/wiki">tutorial</a> and the <a href="../records/13770930">example data</a> used in the tutorial. </p> <p>The shared data includes:</p> <p>1. Triplets for hippocampus shape measured by the radial distance from the medial model for each vertex. The original images contain 30,000 vertices while the shared data contains 49 LDRs. Left and right hemispheres were analyzed separately, each with 15,000 vertices.</p> <p>2. Triplets for 21 white matter tracts measured by fractional anisotropy. The original images contain 32,217 voxels and each tract contains 88 ~ 3503 voxels while the shared data contains 1,034 LDRs. Tracts were analyzed separately.</p> <p>3. Triplets for cortical surface curvature. The original images contain 59,412 vertices while the shared data contains 1,750 LDRs. The entire brain was analyzed as a whole.</p> <p>4. LD matrix and its inverse for 22 chromosomes including 460k genotyped SNPs. LD matrix and its inverse were estimated by using two separate datasets each containing 8.4k white unrelated subjects in UKB. Two regularization levels are provided: {85%, 80%} for heritability and genetic correlations within images and {75%, 70%} for cross-trait genetic correlations.</p> <p>5. LD matrix and its inverse for 22 chromosomes including 1.2 million imputed HapMap3 SNPs. LD matrix and its inverse were estimated by using two separate datasets each containing 42k white unrelated subjects in UKB. Two regularization levels are provided: {98%, 95%} for heritability and genetic correlations within images and {90%, 85%} for cross-trait genetic correlations.</p>
Extracellular recordings and juxtacellular labelling with glass electrodes in the mouse medial septum and hippocampus
<p>This repository contains MAT files consisting of simultaneously recorded mouse medial septal and hippocampal local field potentials (20 kHz sampling rates) and spikes from single medial septal cells. Data were recorded with glass electrodes during spontaneous movement and rest periods, followed by juxtacellular labelling of the medial septal cell. Text files of the spike times and detected hippocampal CA1 theta (5-12 Hz) oscillation trough times are associated with each MAT file.</p> <p>The files are organised by cell (neuron) name. For further details, see the CSV file included with the dataset. These recorded and labelled single cells were originally reported in Joshi et al 2017, Viney et al 2018, and Salib et al 2019.</p> <p>Each MAT file contains the following channels, exported from the original Spike2 (smr) recording files:</p> <p>(1) Details of the recording</p> <p>(2) Detected spikes (in seconds) from the single medial septal cell</p> <p>(3) Movement detection (eg. accelerometer or rotary encoder)</p> <p>(4) Local field potential (medial septum), in mV</p> <p>(5) Local field potential (hippocampal CA1), in mV; see CSV file for precise location (e.g. within stratum pyramidale)</p> <p>This dataset is made available under a Creative Commons Attribution 4.0 International (CC BY 4.0) license: If you share or adapt these data you must give appropriate credit, provide a link to the license, and indicate if changes were made.</p>
Associative Prediction of Visual Shape in the Hippocampus
Open the record for dataset details and reuse information.
Data and scripts related to: Rapid coordination of effective learning by the human hippocampus
<p>This data set contains intracranial EEG data (ASCII format), eye-tracking data from an EyeLink 1000 remote system (edf format), behavioral data, and MATLAB code to reproduce the analyses reported in the manuscript, “Rapid coordination of effective learning by the human hippocampus” published in <em>Science Advances.</em></p> <p>The file <strong>KragelEtal21_SciAdv.zip</strong> contains the raw data divided into folders according to content type, for each of the six participants in the study, and the MATLAB code necessary to reproduce all analyses. MATLAB live scripts provide examples of how to reproduce the main analyses reported in the manuscript.</p> <p>External datasets:</p> <p>In addition to the dataset provided here, three open-access datasets are analyzed in the manuscript.</p> <p> - The <a href="http://figrim.mit.edu/">FIGRIM Dataset</a> contains eye-tracking data during a continuous recognition task.</p> <p> - Two additional eye-tracking datasets during free viewing of repeated scenes are provided in “<a href="https://datadryad.org/stash/dataset/doi:10.5061/dryad.9pf75">An extensive dataset of eye movements during viewing of complex images</a>,” namely the Memory I and Memory II datasets.</p> <p>To reproduce region of interest analyses outside of the hippocampus, both the seven-network cortical parcellation developed by <a href="https://surfer.nmr.mgh.harvard.edu/fswiki/CorticalParcellation_Yeo2011">Yeo, Krienen et al.</a>, and the <a href="https://identifiers.org/neurovault.image:1702">Harvard-Oxford cortical atlas</a> are required.</p> <p>Stimuli:</p> <p>The scenes used in this study are part of <a href="https://cocodataset.org">Microsoft COCO</a>. Scenes were selected from the 2017 Train images. Image identifiers are maintained.</p> <p>Salience model:</p> <p>To reproduce analyses that consider the visual salience of each scene, DeepGaze II model predictions for each stimulus are required. Tensorflow models and a Jupyter notebook demonstrating their use are available for <a href="https://deepgaze.bethgelab.org/">download</a>.</p> <p>Software dependencies:</p> <p>The code in this project was developed using MATLAB r2017b. The following external packages are required for code execution. Some external packages are included in the repository.</p> <p>- fieldtrip (<a href="https://github.com/fieldtrip/fieldtrip">https://github.com/fieldtrip/fieldtrip</a>)<br> - spm12 (<a href="https://github.com/spm/spm12">https://github.com/spm/spm12</a>)<br> - BOSC (<a href="https://doi.org/10.1016/j.neuroimage.2010.08.064">https://doi.org/10.1016/j.neuroimage.2010.08.064</a>)<br> - Edf2Mat (<a href="https://github.com/uzh/edf-converter">https://github.com/uzh/edf-converter</a>)<br> - boundedline (<a href="https://github.com/kakearney/boundedline-pkg">https://github.com/kakearney/boundedline-pkg</a>)<br> - export_fig (https://github.com/altmany/export_fig)</p> <p>License:</p> <p>The included code is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, either version 3 of the License, or any later version. See the file COPYING for more details. The release of this software includes functions from other toolboxes that are covered under their respective licenses.</p>
Data set for "Reward-based learning drives rapid sensory signals in medial prefrontal cortex and dorsal hippocampus necessary for goal-directed behavior"
<p>Data set for: Le Merre P, Esmaeili V, Charrière E, Galan K, Salin P-A, Petersen CCH, Crochet S (2018) Reward-based learning drives rapid sensory signals in medial prefrontal cortex and dorsal hippocampus necessary for goal-directed behavior. Neuron, https://doi.org/10.1016/j.neuron.2017.11.031</p> <p>There are 44 files in this data upload:<br> 1. '2018_LeMerre_Neuron.pdf' - this is a pdf version of the online publication.<br> 2. 'Chronic_LFP_data.mat' - this is a Matlab data structure, which contains all the chronic LFP data for the publication.<br> 3. 'Silicon_Probe_data.mat' - this is a Matlab data structure, which contains all the mPFC silicon probe recording data for the publication.<br> 4. 'Opto_Inactivation_data.mat' - this is a Matlab data structure, which contains all the optogenetic inactivation data for the publication.<br> 5. 'Mus_Inactivation_data.mat' - this is a Matlab data structure, which contains all the pharmacological (Muscimol) inactivation data for the publication.<br> 6. 'Learning_Days_Mtrx.mat' - this is a Matlab data file, which contains the selected training days analyzed for the Trained condition in the Detection Task.<br> 7. 'Exposed_Days_Mtrx.mat' - this is a Matlab data file, which contains the selected days analyzed for the Exposed condition in the Neutral Exposure.<br> 8. 'p_value_colormap.mat' - this is a Matlab data file, which contains the color map used to display the p value in the Matlab codes 'plot_fig2A_SEP_D1_vs_Trained.m'; 'plot_fig2B_Amplitude_D1_vs_Trained.m'; 'plot_fig3A_SEP_D1_vs_Exposed.m'; 'plot_fig4A_SEP_H_vs_M.m’.<br> 9. 'p_value_colormap2.mat' - this is a Matlab data file, which contains the color map used to display the p value in the Matlab code 'plot_figS3B_Stim_vs_Catch_for_significantly_inc_dec_units.m’; ’plot_figS4A_H_vs_M_for_inc_dec_units_and_zscored_PSTH.m’.<br> 10. 'scatterplot_colormap.mat' - this is a Matlab data file, which contains the color map used to display the p value in the Matlab code 'plot_fig2C_Scatterplot_Amplitude_vs_dprime.m'.<br> 11. 'SEP_colormtrx.mat' - this is a Matlab data file, which contains the color map used to display the p value in the Matlab code 'plot_fig1B_Sensory_Evoked_Potentials.m'; 'plot_figS3A_SEP_EMG_amplitude_ReactionTime.m'.<br> 12. 'zscore_colormap.mat' - this is a Matlab data file, which contains the color map used to display the p value in the Matlab code 'plot_fig3D_mPFC_PSTH_and_zscore_DT_vs_NE.m'; 'plot_figS4A_H_vs_M_for_inc_dec_units_and_zscored_PSTH.m’.<br> 13. 'Chronic_LFP_dataViewer.fig' - this is a Matlab Figure file, which is the GUI layout for 'Chronic_LFP_dataViewer.m'.<br> 14. 'Chronic_LFP_dataViewer.m' - this is a Matlab code, which displays the data contained in 'Chronic_LFP_data.mat'.<br> 15. 'Silicon_Probe_dataViewer.fig' - this is a Matlab Figure file, which is the GUI layout for 'Silicon_Probe_dataViewer.m'.<br> 16. 'Silicon_Probe_dataViewer.m' - this is a Matlab code, which displays the data contained in 'Silicon_Probe_data.mat'.<br> 17. 'plot_fig1B_Sensory_Evoked_Potentials.m' - this is a Matlab code, which analyses the data in 'Chronic_LFP_data.mat', and displays the results published in figure 1, panel B (Le Merre et al., 2018).<br> 18. 'plot_fig1C_Silicon_Probe_Hit_trials.m' - this is a Matlab code, which analyses the data in 'Silicon_Probe_data.mat', and displays the results in the same way as the published figure 1, panel C (Le Merre et al., 2018).<br> 19. 'plot_fig2A_SEP_D1_vs_Trained.m' - this is a Matlab code, which analyses the data in 'Chronic_LFP_data.mat', and displays the results in the same way as the published figure 2, panel A (Le Merre et al., 2018).<br> 20. 'plot_fig2B_Amplitude_D1_vs_Trained.m' - this is a Matlab code, which analyses the data in 'Chronic_LFP_data.mat', and displays the results in the same way as the published figure 2, panel B (Le Merre et al., 2018).<br> 21. 'plot_fig2C_Scatterplot_Amplitude_vs_dprime.m' - this is a Matlab code, which analyses the data in 'Chronic_LFP_data.mat', and displays the results in the same way as the published figure 2, panel C (Le Merre et al., 2018).<br> 22. 'plot_fig3A_SEP_D1_vs_Exposed.m' - this is a Matlab code, which analyses the data in 'Chronic_LFP_data.mat', and displays the results in the same way as the published figure 3, panel A (Le Merre et al., 2018).<br> 23. 'plot_fig3B_Amplitude_D1_vs_Exposed.m' - this is a Matlab code, which analyses the data in 'Chronic_LFP_data.mat', and displays the results in the same way as the published figure 3, panel B (Le Merre et al., 2018).<br> 24. 'plot_fig3C_ROC_Trained_vs_Exposed.m' - this is a Matlab code, which analyses the data in 'Chronic_LFP_data.mat', and displays the ROCs in the same way as the published figure 3, panel C (Le Merre et al., 2018).<br> 25. 'plot_fig3C_ROC_Randomization.m' - this is a Matlab code, which analyses the data in 'Chronic_LFP_data.mat', and displays the label shuffled ROCs in the same way as the published figure 3, panel C (Le Merre et al., 2018).<br> 26. 'plot_fig3D_mPFC_PSTH_and_zscore_DT_vs_NE.m' - this is a Matlab code, which analyses the data in 'Silicon_Probe_data.mat', and displays the results in the same way as the published figure 3, panel D (Le Merre et al., 2018).<br> 27. 'plot_fig4A_SEP_H_vs_M.m' - this is a Matlab code, which analyses the data in 'Chronic_LFP_data.mat', and displays the results in the same way as the published figure 4, panel A (Le Merre et al., 2018).<br> 28. 'plot_fig4B_Amplitude_ H_vs_M.m' - this is a Matlab code, which analyses the data in 'Chronic_LFP_data.mat', and displays the results in the same way as the published figure 4, panel B (Le Merre et al., 2018).<br> 29. 'plot_fig4C_mPFC_PSTH_Hit_vs_Miss.m' - this is a Matlab code, which analyses the data in 'Silicon_Probe_data.mat', and displays the results in the same way as the published figure 4, panel C, left panel (Le Merre et al., 2018).<br> 30. 'plot_fig4C_Scatterplot_modulation_Hit_vs_Miss.m' - this is a Matlab code, which analyses the data in 'Silicon_Probe_data.mat', and displays the results in the same way as the published figure 4, panel C, right panel (Le Merre et al., 2018).<br> 31. 'plot_fig4D_Photoinhibitions.m' - this is a Matlab code, which analyses the data in 'Opto_Inactivation_data.mat', and displays the results published in figure 4, panel D (Le Merre et al., 2018).<br> 32. 'plot_figS2D_Performance_DetectionTask_NeutralExposition.m' - this is a Matlab code, which analyses the data in 'Chronic_LFP_data.mat', and displays the results in the same way as the published figure S2, panel D (Le Merre et al., 2018).<br> 33. 'plot_figS3A_SEP_EMG_amplitude_ReactionTime.m' - this is a Matlab code, which analyses the data in 'Chronic_LFP_data.mat', and displays the results in the same way as the published figure S3, panel A (Le Merre et al., 2018).<br> 34. 'plot_figS3B_Stim_vs_Catch_for_significantly_inc_dec_units.m' - this is a Matlab code, which analyses the data in 'Silicon_Probe_data.mat', and displays the results in the same way as the published figure S3, panel B (Le Merre et al., 2018).<br> 35. 'plot_figS4A_H_vs_M_for_inc_dec_units_and_zscored_PSTH.m' - this is a Matlab code, which analyses the data in 'Silicon_Probe_data.mat', and displays the results in the same way as the published figure S4, panel A (Le Merre et al., 2018).<br> 36. 'plot_figS4B_Pharmacological_Inactivations.m' - this is a Matlab code, which analyses the data in 'Mus_Inactivation_data.mat', and displays the results published in figure S4 (Le Merre et al., 2018).<br> 37. 'Load_LFP_Multisite_database.m' - this is a Matlab code, which is called in the Matlab codes that analyze the data in 'Chronic_LFP_data.mat'.<br> 38. 'Load_Silicon_Probe_database.m' - this is a Matlab code, which is called in the Matlab codes that analyze the data in 'Silicon_Probe_data.mat'.<br> 39. 'Load_Optogenetic_Inactivation_database.m' - this is a Matlab code, which is called in the Matlab code that analyzes the data in 'Opto_Inactivation_data.mat'.<br> 40. 'Load_Pharmacological_Inactivation_database.m' - this is a Matlab code, which is called in the Matlab code that analyzes the data in 'Mus_Inactivation_data.mat'.<br> 41. 'bonf_holm.m' - this is a Matlab code developed by D. M. Groppe, which is called in the Matlab code 'plot_figS4B_Pharmacological_Inactivations.m':<br> https://ch.mathworks.com/matlabcentral/fileexchange/28303-bonferroni-holm-correction-for-multiple-comparisons<br> 42. 'boundedline.m' - this is a Matlab code developed by K. Kearney, which is called in the Matlab codes 'plot_fig1C_Silicon_Probe_Hit_trials.m'; 'plot_fig2A_SEP_D1_vs_Trained.m'; 'plot_fig3A_SEP_D1_vs_Exposed.m’; 'plot_fig3C_ROC_Trained_vs_Exposed.m'; 'plot_fig3D_mPFC_PSTH_and_zscore_DT_vs_NE.m'; 'plot_fig4A_SEP_H_vs_M.m'; 'plot_fig4C_mPFC_PSTH_Hit_vs_Miss.m'; 'plot_figS3B_Stim_vs_Catch_for_significantly_inc_dec_units.m'; 'plot_figS4A_H_vs_M_for_inc_dec_units_and_zscored_PSTH.m':<br> https://ch.mathworks.com/matlabcentral/fileexchange/27485-boundedline-m<br> 43. 'inpaint_nans.m' - this is a Matlab code, which is called in the Matlab code 'boundedline.m'.<br> 44. 'PSTH_Simple.m' - this is a Matlab code developed by V. Esmaeili, which is called in the Matlab codes 'plot_fig1C_Silicon_Probe_Hit_trials.m'; 'plot_fig3D_mPFC_PSTH_and_zscore_DT_vs_NE.m'; 'plot_fig4C_mPFC_PSTH_Hit_vs_Miss.m'; 'plot_figS3B_Stim_vs_Catch_for_significantly_inc_dec_units.m'; 'plot_figS4A_H_vs_M_for_inc_dec_units_and_zscored_PSTH.m’.</p>
Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus: optogenetical stimulation data
<p>This dataset contains 2-photon calcium imaging data from the paper 'Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus'. This is the calcium imaging data from CA1 pyramidal cells and interneurons, including both spontaneous activity and activity in response to optogenetic stimulation.</p> <p><strong>Data organization</strong></p> <p>This dataset contains all the data related to the all-optical part of the paper and was analyzed using the code from the <a href="https://gitlab.com/cossartlab/bocchio-vorobyev-et-al-2023/-/tree/main/Optogenetical%20stimulation?ref_type=heads">lab repository</a>. The original calcium imaging movies are excluded due to size limitations.</p> <p><strong>Further information</strong></p> <p>Please email vorobev[a t]phystech.edu if you need further information on the data or if you wish to access the raw calcium imaging movies (not uploaded here due to storage limitations).</p>
Neurometabolic changes in a rat pup model of type C HE - 1H MRS dataset (hippocampus)
<p>1H MRS in hippocampus was used to study longitudinally the effect of chronic liver disease (bile duct ligated rat model) in the brain (type C hepatic encephalopathy) of animals having developed disease a post natal day 15 (p15) corresponding to ~4 months old human brain. The dataset contains MR spectra and LCModel Quanifications from 7 bile duct ligated and 8 control animals at week 2, 4 and 6 after surgery.</p> <p>Please cite the following manuscript if you are using these data</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/37148431/">Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset - PubMed (nih.gov)</a></p>
Structural and Molecular Analysis of Adult Mouse Astrocytes and Vascular Connectivity in the Cortex and Hippocampus
<p>After image acquisition (0-RAW_CL230331_E2_serie1) and deconvolution (1-Deconvolved_CL230331_E2_serie1) using confocal microscopy and the SVI Huygens software,respectively, the image processing was conducted using Imaris, Fiji, and Matlab software. This process involved a sequence of manual operations (2-Imaris_surfaces_CL230331_E2_serie1) and custom Groovy scripts (5-Groovy scripts).</p> <p>The dataset analysis (3-Imaris_final_CL230331_E2_serie1_ims) allowed for a deeper investigation of morphological and molecular properties of adult mouse astrocytes (4-Image analysis_CL230331_E2_serie1) in two brain regions, the Isocortex and the Hippocampus, known to be interconnected to support multiple cognitive functions.</p>
MR Spectra from rat hippocampus with LCModel quantification and the corresponding basis set
<p>This folder contains the LCModel quantifications of spectra acquired in hippocampus from 7 rats. The spectra were quntified using six different DKNTMN (spline stiffness) values (0.1, 0.25, 0.4, 0.5, 1, 5). In the folder Control_files_Basis_set you can find all the control files used in this quantification along with the corresponding basis set (metabolites/simulated using NMRScopeB from jMRUI and <em>in vivo </em>parameters + full MM spectrum).</p> <p>Please cite the following manuscript if you are using the data</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/34268821/">In vivo macromolecule signals in rat brain 1 H-MR spectra at 9.4T: Parametrization, spline baseline estimation, and T2 relaxation times - PubMed (nih.gov)</a><br> </p>
Cell type specificity of glucocorticoid signaling in the adult mouse hippocampus
<p>The present study is based on the 10X scRNA-seq dataset published by the Allen Institute for Brain Science and publicly available at: <a href="https://portal.brain-map.org/atlases-and-data/RNA-seq/mouse-whole-cortex-and-hippocampus-10x">https://portal.brain-map.org/atlases-and-data/RNA-seq/mouse-whole-cortex-and-hippocampus-10x</a>. The cells from the hippocampus region were selected from the gene count expression matrix and pre-processed in R v3.6.1 according to the Seurat v3.1.5 standard pre-processing workflow for quality control, normalization, and analysis of scRNA-seq data. Here we make the final seurat object and other datasets further used in the code (<a href="https://github.com/eviho/10XHip2021_VihoEMG">https://github.com/eviho/10XHip2021_VihoEMG</a>) available for download. </p>
Fig. 4. Hippocampus colemani, this specimen not collected. A in A New Pygmy Seahorse (Pisces: Syngnathidae: Hippocampus) from Lord Howe Island
Fig. 4. Hippocampus colemani, this specimen not collected. A probable male as it appears to have a pouch. Photo by Neville Coleman.
Fig. 1. Hippocampus colemani, holotype AMS I41181-001 in A New Pygmy Seahorse (Pisces: Syngnathidae: Hippocampus) from Lord Howe Island
Fig. 1. Hippocampus colemani, holotype AMS I41181-001 (left) and paratype AMS I41181-002 (right), both female.
Barcoding of episodic memories in the hippocampus of a food-caching bird
<p>The hippocampus is critical for episodic memory. Although hippocampal activity represents place and other behaviorally relevant variables, it is unclear how it encodes numerous memories of specific events in life. To study episodic coding, we leveraged the specialized behavior of chickadees – food-caching birds that form memories at well-defined moments in time whenever they cache food for subsequent retrieval. Our recordings during caching revealed very sparse, transient barcode-like patterns of firing across hippocampal neurons. Each "barcode" uniquely represented a caching event and transiently reactivated during the retrieval of that specific cache. Barcodes co-occurred with the conventional activity of place cells, but were uncorrelated even for nearby cache locations that had similar place codes. We propose that animals recall episodic memories by reactivating hippocampal barcodes. Similarly to computer hash codes, these patterns assign unique identifiers to different events and could be a mechanism for rapid formation and storage of many non-interfering memories.</p>
FIGURE 4 in Population structure of the seahorse Hippocampus reidi (Syngnathiformes: Syngnathidae) in a Brazilian semi-arid estuary
FIGURE 4 | Proportion of color patterns (A) and holdfast use (B) of Hippocampus reidi in the Pacoti River estuary, Ceará, Brazil, between December 2017 and November 2018.
FIGURE 3 in Population structure of the seahorse Hippocampus reidi (Syngnathiformes: Syngnathidae) in a Brazilian semi-arid estuary
FIGURE 3 | Spatial variation in the proportion of pregnant males of Hippocampus reidi along the salinity gradient in the Pacoti River estuary, Ceará, Brazil, between December 2017 and November 2018. Y = pregnant male record, N = non-pregnant male record.
FIGURE 2 in Population structure of the seahorse Hippocampus reidi (Syngnathiformes: Syngnathidae) in a Brazilian semi-arid estuary
FIGURE 2 | Temporal variation of environmental variables: (A) salinity and (B) water transparency (cm), and Hippocampus reidi population variables: (C) population density (ind.m-2), (D) proportion of pregnant males (Y = pregnant male record, N = non-pregnant male record) and (E) individual height (cm), in the Pacoti River estuary, Ceará, Brazil, between December 2017 and November 2018. The months of the rainy season are highlighted in blue.
FIGURE 1 in Population structure of the seahorse Hippocampus reidi (Syngnathiformes: Syngnathidae) in a Brazilian semi-arid estuary
FIGURE 1 | Geographic location of the Pacoti River estuary, Ceará, Brazil (A, B), indicating Hippocampus reidi sampling locations (A to K) (C).
Fig. 3 in Scientific Note Novel sex-related characteristics of the longsnout seahorse Hippocampus reidi Ginsburg, 1933
Fig. 3. Occurrence of dorsolateral spots according to height in males of Hippocampus reidi. Males presenting dorsolateral spots (black bars); males without dorsolateral spots (grey bars).
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.