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42 results for “Human adenovirus”
Deep splicing plasticity of the human adenovirus type 5 transcriptome as a driver of virus evolution nanopore data 48hpi
<p>Adenovirus infected MRC5 cells direct RNA sequencing of the mRNA using nanopore. From the paper Deep splicing plasticity of the human adenovirus type 5 transcriptome as a driver of virus evolution. Both the uncorrected fastq files and the lordec corrected files together with the normalised illumina data used to correct the nanpore data are here.</p>
AYUKA Genotyper Databases - Human Adenovirus (HAdV)
<p>Database files for several k-lenghts to be used in the AYUKA method to classify adenovirus genotypes</p>
Shift in Circulating Human Adenovirus Species Leading to Nationwide Outbreak - China, January 2023-August 2024
<p><span>Detailed methodologies and data quality control standards are provided</span><span> in the supplementary materials</span></p>
Human adenovirus serotype 5 infection dysregulates cysteine, purine, and unsaturated fatty acid metabolism in fibroblasts
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Shift in Circulating Human Adenovirus Species Leading to Nationwide Outbreak - China, January 2023-August 2024
<p><span>The list of pathogens detected by the tNGS used in this study</span></p>
A Study of Heterologous Vaccine Regimen of Adenovirus Serotype 26 Mosaic4 Human Immunodeficiency Virus(Ad26.Mos4.HIV), Adjuvanted Clade C gp140 and Mosaic gp140 to Prevent HIV-1 Infection Among Cis-ge
ClinicalTrials.gov study NCT03964415. IPD Sharing: YES. Countries: 9. Publications: 1.
Data from: Alpha-defensin binding expands human adenovirus tropism
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Data from: First-in-human randomized controlled trial of an oral, replicating Adenovirus 26 vector vaccine for HIV-1
Background: Live, attenuated viral vectors that express HIV-1 antigens are being investigated as an approach to generating durable immune responses against HIV-1 in humans. We recently developed a replication-competent, highly attenuated Ad26 vector that expresses mosaic HIV-1 Env (rcAd26.MOS1.HIV-Env, "rcAd26"). Here we present the results of a first-in-human, placebo-controlled clinical trial to test the safety, immunogenicity and mucosal shedding of rcAd26 given orally. Methods: Healthy adults were randomly assigned to receive a single oral dose of vaccine or placebo at 5:1 ratio in a dosage escalation of 10^8 to 10^11 rcAd26 VP (nominal doses) at University of Rochester Medical Center, Rochester, NY, USA. Participants were isolated and monitored for reactogenicity for 10 days post-vaccination, and adverse events were recorded up to day 112. Rectal and oropharyngeal secretions were evaluated for shedding of the vaccine. Humoral and cellular immune responses were measured. Household contacts were monitored for secondary vaccine transmission. Results: We enrolled 22 participants and 11 household contacts between February 7 and June 24, 2015. 18 participants received one dose of HIV-1 vaccine and 4 participants received placebo. The vaccine caused only mild to moderate adverse events. No vaccine-related SAEs were observed. No infectious rcAd26 viral particles were detected in rectal or oropharyngeal secretions from any participant. Env-specific ELISA and ELISPOT responses were undetectable. No household contacts developed vaccine-induced HIV-1 seropositivity or vaccine-associated illness. Conclusions: The highly attenuated rcAd26.MOS1.HIV-Env vaccine was well tolerated up to 10^11 VP in healthy, HIV-1-uninfected adults, though the single dose was poorly immunogenic suggesting the replicative capacity of the vector was too attenuated. There was no evidence of shedding of infectious virus or secondary vaccine transmission following the isolation period. These data suggest the use of less attenuated viral vectors in future studies of live, oral HIV-1 vaccines. Clinical Trials Registration: NCT02366013
Data from: Multiple cross-species transmission events of human adenoviruses (HAdV) during hominine evolution
Human adenoviruses (HAdV; species HAdV-A to -G) are highly prevalent in the human population, and represent an important cause of morbidity and, to a lesser extent, mortality. Recent studies have identified close relatives of these viruses in African great apes, suggesting that some HAdV may be of zoonotic origin. We analyzed more than 800 fecal samples from wild African great apes and humans to further investigate the evolutionary history and zoonotic potential of hominine HAdV. HAdV-B and -E were frequently detected in wild gorillas (55%) and chimpanzees (25%), respectively. Bayesian ancestral host reconstruction under discrete diffusion models supported a gorilla and chimpanzee origin for these viral species. Host switches were relatively rare along HAdV evolution, with about ten events recorded in 4.5 My. Despite presumably rare direct contact between sympatric populations of the two species, transmission events from gorillas to chimpanzees were observed, suggesting that habitat and dietary overlap may lead to fecal-oral cross-hominine transmission of HAdV. Finally, we determined that two independent HAdV-B transmission events to humans occurred more than 100,000 years ago. We conclude that HAdV-B circulating in humans are of zoonotic origin and have probably affected global human health for most of our species lifetime.
Most Closely Human Leukocyte Antigen (HLA)-Matched Adenovirus-specific T Lymphocytes (Viralym-A)
ClinicalTrials.gov study NCT02276820. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Recombinant Human Adenovirus Type 5 Plus HAIC of FOLFOX for Intrahepatic Cholangiocarcinoma
ClinicalTrials.gov study NCT05124002. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Nebulized Inhalation of Recombinant Human p53 Adenovirus Injection for Treatment of Multiple Ground-Glass Lung Nodules: A Single-Arm Clinical Study
ClinicalTrials.gov study NCT07150416. IPD Sharing: YES. Countries: 1. Publications: 10.
TACE Plus Recombinant Human Adenovirus for Hepatocellular Carcinoma
ClinicalTrials.gov study NCT01869088. IPD Sharing: Not stated. Countries: 1. Publications: 32.
Data from: First-in-human randomized controlled trial of an oral, replicating Adenovirus 26 vector vaccine for HIV-1
Open the record for dataset details and reuse information.
Data from: Multiple cross-species transmission events of human adenoviruses (HAdV) during hominine evolution
Open the record for dataset details and reuse information.
Raw data Uptake without inactivation of human adenovirus type 2 by Tetrahymena pyriformis ciliates
<p>Tomograms showing HAdV2 particles inside protist slices observed via TEM</p> <p>All raw data (viral concentration, virus removal values, food vacuole count) used in the study</p> <p>R code for MPN quantification in digestion and egestion expriments</p>
Expression data from human monocyte derived macrophages infected with adenovirus expressing HIV-1 Vpr
GEO Series GSE56591. Homo sapiens. 4 samples. Type: Expression profiling by array.
The extracellular interactome of the human Adenovirus family reveals diverse strategies for immunomodulation
GEO Series GSE78518. Homo sapiens; Human mastadenovirus A. 96 samples. Type: Protein profiling by protein array.
Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans
GEO Series GSE190850. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic investigation of differential cellular reprogramming of infected cells by human adenovirus 5 E1A mutants
GEO Series GSE288390. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.