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63 results for “IGF1”
Ojeok-san Enhances Platinum Sensitivity in Ovarian Cancer by Regulating Adipocyte Paracrine IGF1 Secretion
<p><strong>Figure 1 Adipocytes promote platinum drug resistance in OvCa cells</strong></p> <p>(A-B) The effects of Adipo-CM treatment on cell viability and apoptosis level were detected by CCK-8 and flow cytometry. (C) The expression of proliferation-related and apoptosis-related proteins was detected by western blot. (D) The IC<sub>50</sub> values of different concentrations of cisplatin and carboplatin treatment on OvCa cells were detected by CCK-8. * <em>p</em><0.05.</p> <p> </p> <p><strong>Figure 2 Adipocytes promote OvCa resistance to platinum drugs through paracrine secretion of IGF1</strong></p> <p>(A) The expression of IGF1 in HPAd cells was detected by western blot. (B) The concentration of IGF1 in culture media of HPAd cells was detected by ELISA. (C-D) The effects of different treatments on SKOV3 cell viability and apoptosis level were detected by CCK-8 and flow cytometry. (E) The expression of proliferation-related and apoptosis-related proteins was detected by western blot. (F) The IC<sub>50</sub> values of different concentrations of cisplatin and carboplatin treatment on SKOV3 cells were detected by CCK-8. *VS oe-NC+DMSO, #VS oe-IGF1+DMSO, * <em>p</em><0.05.</p> <p> </p> <p><strong>Figure 3 OJS inhibits adipocyte paracrine secretion of IGF1 to regulate OvCa progression</strong></p> <p>(A-B) The expression of IGF1 in HPAd cells and cell culture supernatant was detected by western blot and ELISA, respectively. (C-D) The effects of different treatments on SKOV3 cell viability and apoptosis level were detected by CCK-8 and flow cytometry. (E) The expression of proliferation-related and apoptosis-related proteins was detected by western blot. (F) The IC<sub>50</sub> values of different concentrations of cisplatin and carboplatin treatment on SKOV3 cells were detected by CCK-8. *VS Adipo-CM, #VS Adipo-CM2, <em>p</em><0.05.</p> <p> </p> <p><strong>Figure 4 OJS enhances the anticancer activity of cisplatin in SKOV3 and HPAd xenograft models</strong></p> <p>(A-C) Tumor growth under different treatments. (D) The effects of OJS and cisplatin on the damage and morphological changes of major organs in mice were detected by H&E staining. (E) The expression of proliferation-related and apoptosis-related proteins was detected by IHC. *VS control, #VS cisplatin, <em>p</em><0.05.</p> <p> </p>
Establishment of Reference Values for Insulin-like Growth Factor 1 (IGF1) in the General Population
ClinicalTrials.gov study NCT01831648. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Cinnamomum Cassia Effect on IGF1 and Metabolic Control in Patients With DM2 Without Glycemic Control Metformin Treated
ClinicalTrials.gov study NCT03610412. IPD Sharing: YES. Countries: 1. Publications: 32.
The Association Between Diabetes Mellitus, Oral Lichen Planus and Insulin-like Growth Factors 1 and 2 (IGF1 and IGF2)
ClinicalTrials.gov study NCT03257228. IPD Sharing: NO. Countries: 0. Publications: 3.
Serum IGF1 on Female HFpEF Patients
ClinicalTrials.gov study NCT07015554. IPD Sharing: NO. Countries: 1. Publications: 0.
Autocrine IGF1 signaling mediates pancreatic tumor cell dormancy in the absence of oncogenic drivers
GEO Series GSE93946. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Kupffer cells control neonatal hepatic glucose metabolism via Igf1 signaling
GEO Series GSE283799. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Amino acids and IGF1 regulation of fish muscle growth revealed by transcriptome and microRNAome integrative analyses of pacu (Piaractus mesopotamicus) myotubes [RNA-seq]
GEO Series GSE192681. Piaractus mesopotamicus. 9 samples. Type: Expression profiling by high throughput sequencing.
A distal super enhancer mediates estrogen-dependent mouse uterine–specific gene transcription of Insulin-like growth factor 1 (Igf1)
GEO Series GSE125972. Mus musculus. 38 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
NECTIN1 controls an IGF1-dependent adhesion switch in melanoma spreading
GEO Series GSE149481. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1
GEO Series GSE296073. Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing.
Hyperactive PDGFRβ signaling induces cataractogenesis via TGFβ and STAT5-IGF1
GEO Series GSE302408. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
IGF1-receptor signalling attenuates the age-related decline of diastolic cardiac function
GEO Series GSE32936. Mus musculus. 8 samples. Type: Expression profiling by array.
Decline in IGF1 in CXCL12-Abundant Reticular (CAR) Cells Causes Myeloid-Biased Hematopoiesis Observed During Aging
GEO Series GSE210584. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche
GEO Series GSE126488. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing.
Activation of the IGF1 pathway mediates changes in cellular contractility and motility in single-suture craniosynostosis
GEO Series GSE75524. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Elucidating oncogenic effects of androgen signaling in prostate tumorigenesis through aberrant activation of IGF1 and WNT signaling pathways [scRNA-Seq 1]
GEO Series GSE164969. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional analysis of IGF1 treatment of mouse tenocytes over a 24 hour time course
GEO Series GSE131786. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Amino acids and IGF1 regulation of fish muscle growth revealed by transcriptome and microRNAome integrative analyses of pacu (Piaractus mesopotamicus) myotubes [miRNA-seq]
GEO Series GSE192682. Piaractus mesopotamicus. 9 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Mir-483 regulates the senescence of human adipose-derived mesenchymal stem cells through IGF1
GEO Series GSE138879. Homo sapiens. 2 samples. Type: Non-coding RNA profiling by high throughput sequencing.
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