Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
33
datasets available to search
ShareScore release 0.9.0
Dataset results
33 results for “IgH locus”
Altered 3D chromatin structure permits inversional recombination at the IgH locus
<p>Immunoglobulin heavy chain (<i>IgH</i>) genes are assembled by two sequential DNA rearrangement events that are initiated by recombinase activating gene products (RAG) 1 and 2. Diversity gene segments (D<sub>H</sub>) rearrange first, followed by variable (V<sub>H</sub>) gene rearrangements. Here we provide evidence that each rearrangement step is guided by different rules of engagement between rearranging gene segments. D<sub>H</sub> gene segments, that recombine by deletion of intervening DNA, must be located within a RAG1/2 scanning domain for efficient recombination. In the absence of intergenic control region 1, a regulatory sequence that delineates the RAG scanning domain on WT <i>IgH</i> alleles, V<sub>H</sub> and D<sub>H</sub> gene segments can recombine with each other by both deletion and inversion of intervening DNA. We propose that V<sub>H</sub> gene segments find their targets by diffusion-controlled mechanisms. These distinct mechanisms may underlie differential allelic choice associated with each step of <i>IgH</i> gene assembly.</p>
Altered 3D chromatin structure permits inversional recombination at the IgH locus
Open the record for dataset details and reuse information.
5C Chromatin interactions in the Igh locus in activated splenic B cells
GEO Series GSE183195. Mus musculus. 2 samples. Type: Other.
Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes
GEO Series GSE208602. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing; Other.
Enhancers of the PAIR4 regulatory module promote distal VH gene recombination at the Igh locus
GEO Series GSE214869. Mus musculus. 59 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
5C Chromatin interactions in the Igh locus in resting splenic B cells
GEO Series GSE183574. Mus musculus. 2 samples. Type: Other.
Non-coding transcription within the Igh distal VH region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells
GEO Series GSE40822. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Flexible chromatin loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire
GEO Series GSE43008. Mus musculus. 112 samples. Type: Other; Genome binding/occupancy profiling by high throughput sequencing.
Wapl repression by Pax5 promotes loop extrusion and V gene recombination at the Igh locus
GEO Series GSE140975. Mus musculus. 170 samples. Type: Other; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Med1 facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination.
GEO Series GSE62969. Mus musculus. 18 samples. Type: Other.
Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes [Hi-C]
GEO Series GSE208600. Mus musculus. 16 samples. Type: Other.
5C Chromatin interactions in the Igh locus in B cell progenitors
GEO Series GSE76086. Mus musculus. 6 samples. Type: Other.
Polymorphism of the IgH Locus Regulatory Region as a Prognostic Factor During Immune Pathologies.
ClinicalTrials.gov study NCT01715623. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Altered 3D chromatin structure permits inversional recombination at the IgH locus
GEO Series GSE135763. Mus musculus. 12 samples. Type: Other.
Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes [RNA-seq]
GEO Series GSE208601. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Sequential enhancer sequestration dysregulates recombination center formation at the IgH locus
GEO Series GSE109631. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
A distinct motif for numerous CTCF binding sites in the murine IgH locus
GEO Series GSE124153. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by genome tiling array.
Analysis of the effect of two IgH superenhancer deletion on IgH locus transcription
GEO Series GSE90760. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination at the IgH locus in a cell-type specific manner
GEO Series GSE75018. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by genome tiling array.
Altered 3D chromatin structure permits inversional recombination at the IgH locus
GEO Series GSE133185. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.