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Dataset results
27 results for “Impact disruption”
Data for a publication "Impact disruption of Bjurböle porous chondritic projectile"
<p>This archive contains raw and processed research data and photographic documentation for a publication "<em><strong>Impact disruption of Bjurböle porous chondritic projectile</strong></em>" by Kohout et al. The sample identifiers are consistent with the one used in the publication.</p> <p>Content:</p> <ol> <li><strong>Bjurböle photos.zip</strong>, <strong>Bjurböle photos II.zip</strong>, and <strong>Bjurböle photos III.zip</strong> - Photographs of studied Bjurböle meteorites from Finnish Museum of Natural History as well as from worldwide collections. Unless specified otherwise in the photographs (worldwide collections) the photo credits are Tomas Kohout, Assi-Johanna Soini, Arto Luttinen, University of Helsinki.</li> <li><strong>Meteoriteidentifier.ply</strong> - 3D shape reconstructions of studied Bjurböle and Chelyabinsk meteorites. By default a 3D mesh reconstruction with relaxed fitting was applied to partial aligned laser scans. In certain cases where multiple reconstruction techniques were applied (e.g. volume merge) this is indicated in file name.</li> <li><strong>All tables.xlsx</strong> - Spreadsheet file containing the tables presented in the publication</li> </ol>
Endocrine disruption: the noise in available data adversely impact the models' performance
<p>This paper is devoted to the analysis of available experimental data and preparation of predictive models for binding affinity of molecules with respect to two nuclear receptors involved in endocrine disruption: the Estrogen (ER) and the Androgen (AR) receptor. The ED-relevant data were retrieved from multiple sources, including the CERAP, CoMPARA, and the Tox21 data challenge projects as well as ChEMBL and PubChem databases. Data analysis performed with the help of Generative Topographic Mapping technique revealed the problem of a low agreement between experimental values issued from different sources.</p> <p>Collected data were used to train both classification models for AR and ER binding activities and regression models for Relative Binding Affinity (RBA) and median Inhibition Concentration (IC50) models. These models displayed relatively poor performance in classification (sensitivities ER = 0.34, AR = 0.49) and in regression (determination coefficient R<sup>2</sup> for the RBA and IC50 models in external validation varied from 0.44 to 0.76). Our analysis demonstrates that low models performances resulted from misinterpreted experimental endpoints or wrongly reported values.</p> <p>Developed models and collected data sets included of 6215 (ER) and 3789 (AR) unique compounds; they are freely available.</p> <p>The repository includes data on estrogen and androgen receptor binding behavior (binder, non-binder), median inhibitory concentration (IC50) and relative binding affinity (RBA). </p> <p><strong>SDF fields:</strong></p> <ul> <li><em>DB</em> = database; where: COMPARA = Collaborative Modelling Project for Androgen Receptor Activity; CERAPP = Collaborative Estrogen Receptor Activity Prediction Project; Tox-DC = data from Tox21 program; PubChem = data from PubChem. </li> <li><em>Set</em> = whether the compound was used in training or test set for the given model</li> <li><em>Receptor</em> = AR stands for Androgen Receptor and ER stands for Estrogen Receptor</li> <li><em>binding_prp</em> = binding behaviour for the classification model (ER and AR). 1 = binder; = non-binder</li> <li><em>IC50 (nM) </em>and <em>logIC50</em> = median inhibitory concentration values in nanoMolar and log.</li> <li><em>RBA(%) </em>and <em>logRBA</em> = relative binding affinity values in % and log.</li> </ul>
Data for Marshall et al, "Microbial metabolism disrupts cytokine activity to impact host immune response"
<p>Raw data for publication "Microbial metabolism disrupts cytokine activity to impact host immune response", Marshall EKP et al. The archive is organized into folders containing raw data pertaining to each figure.</p>
The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU
ClinicalTrials.gov study NCT04737200. IPD Sharing: NO. Countries: 1. Publications: 1.
Impact of Chronic Circadian Disruption vs. Chronic Sleep Restriction on Metabolism
ClinicalTrials.gov study NCT02171273. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Disrupting butterfly caterpillar microbiomes does not impact their survival and development
Open the record for dataset details and reuse information.
Data and R code for Anthropogenic stressors impact fish sensory development and survival via thyroid disruption
<p>The zip document contains all the data and R code used in the manuscript "Anthropogenic stressors impact fish sensory development and survival via thyroid disruption".</p>
Data from: Towards large scale automated cage monitoring – Diurnal rhythm and impact of interventions on in-cage activity of C57BL/6J mice recorded 24/7 with a non-disrupting capacitive-based technique
Abstract Background and aims Automated recording of laboratory animal's home cage behavior is receiving increasing attention since such non-intruding surveillance will aid in the unbiased understanding of the normal animal cage behavior potentially improving animal experimental reproducibility. Material and methods Here we investigate activity of group held (5 mice/cage) female C57BL/6J mice (mus musculus) housed in standard Individually Ventilated Cages (IVC cages) across three test-sites: Consiglio Nazionale delle Ricerche (Rome, Italy), The Jackson Laboratory (Bar Harbor, USA) and Karolinska Insititutet (Stockholm, Sweden). Additionally, comparison of female and male C57BL/6J mice was done at KI. Activity was recorded using a capacitive-based sensor placed non-intrusively on the cage rack under the home cage collecting activity data every 250 msec, 24/7. The data collection was analyzed using non-parametric rank-based analysis of variance (nparLD) for longitudinal data comparing sites, weekdays and sex. Results The system detected an increase in activity preceding and peaking around lights-on followed by a decrease to a rest pattern. At lights off, activity increased substantially displaying a distinct temporal variation across this period. We also documented impact on mouse activity that standard animal handling procedures have, e.g. cage-changes, and show that even simple procedures are stressors impacting in-cage activity. These key observations replicated across the three test-sites, however, it is also clear that, apparently minor local environmental differences generate significant behavioral variances between the sites and within sites across weeks. Comparison of gender revealed differences in activity in the response to cage-change lasting for days in male but not female mice; and apparently also impacting the response to other events such as lights-on in males. Females but not males showed a larger tendency for week-to-week variance in activity possibly reflecting estrous cycling. Conclusions These data demonstrate that real-time home cage monitoring is scalable and run in real time, providing complementary information for animal welfare measures, experimental design and phenotype characterization.
Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving
ClinicalTrials.gov study NCT01822587. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Investigating the Impact of Methylphenidate on Neural Response in Disruptive Behavioral Disorder
ClinicalTrials.gov study NCT02247986. IPD Sharing: Not stated. Countries: 0. Publications: 3.
Disrupted Connections: The Impact of Acute Stress on Memory Integration
ClinicalTrials.gov study NCT07055555. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: Towards large scale automated cage monitoring – Diurnal rhythm and impact of interventions on in-cage activity of C57BL/6J mice recorded 24/7 with a non-disrupting capacitive-based technique
Open the record for dataset details and reuse information.
The impact of late gestation circadian disruption, by two weeks of exposure to chronic light dark phase from 5 weeks before expected calving to 3 weeks expected calving, on dairy cattle hepatic and ma
GEO Series GSE168914. Bos taurus. 24 samples. Type: Expression profiling by high throughput sequencing.
Molecular mechanism impacted by circadian disruption underscores the importance of timed anti-cancer treatment
GEO Series GSE119668. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Evaluating the endocrine disrupting impacts of paper mill exposure on the Eastern Mosquitofish (Gambusia holbrooki) by gene expression analysis
GEO Series GSE49238. Gambusia holbrooki. 8 samples. Type: Expression profiling by array.
Impact of Sleep Disruption on the Menstrual Cycle
ClinicalTrials.gov study NCT00456222. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact of Exogenous Ketones on Sleep Disruption in Vulnerable Populations
ClinicalTrials.gov study NCT06655649. IPD Sharing: YES. Countries: 1. Publications: 0.
Extracellular Impact of Ultrasound-induced Blood-brain Barrier Disruption
ClinicalTrials.gov study NCT05733312. IPD Sharing: NO. Countries: 1. Publications: 0.
From cohorts to molecules: adverse impacts of endocrine disrupting mixtures. Transcriptomics Analysis
GEO Series GSE171566. Homo sapiens. 171 samples. Type: Expression profiling by high throughput sequencing.
Zinc deficiency impacts CO2 assimilation and disrupts copper homeostasis in Chlamydomonas reinhardtii
GEO Series GSE41096. Chlamydomonas reinhardtii. 1 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.