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1,831 results for “Infarction”
SHOCK Trial - Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock
<p>The leading cause of death in patients hospitalized for acute myocardial infarction is cardiogenic shock. We conducted a randomized trial to evaluate early revascularization in patients with cardiogenic shock. In patients with cardiogenic shock, emergency revascularization did not significantly reduce overall mortality at 30 days. However, after six months there was a significant survival benefit. Our conclusion was that early revascularization should be strongly considered for patients with acute myocardial infarction complicated by cardiogenic shock. We are making original data that was collected for this trial available here for further analysis.</p>
Diversity in the Expressed Genomic Host Response to Myocardial Infarction - Validation Dataset
<p>External validation was performed by separately hierarchically clustering 934 patients with STEMI in an independent cohort[1] into 2 groups (232 and 702 individuals) based on Illumina HT12v4-profiled PBMC expression (median time 21 hour between cardiac catheterization and blood sampling). Probes with most variable expression intensities (SD≥0.5, 216 probes, excluding ribosomal genes) were used. From the 20 most differentially expressed genes in the discovery cohort described in the manuscript Toma et al. 2022 [2], 19 were available in the validation cohort.</p> <p>Column names include the Illumina identifyer and the mapped gene name as used in the discovery cohort. Values are log2-transformed, quantile-normalized, batch-corrected values, see also [1] for methodological details.</p> <p>Acknowledgement:</p> <p>This work is supported by LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig. LIFE is funded by means of the European Union, by the European Regional Development Fund (ERDF) and by means of the Free State of Saxony within the framework of the excellence initiative.</p> <p> </p> <p>1) Teren A, Kirsten H, Beutner F, Scholz M, Holdt LM, Teupser D, Gutberlet M, Thiery J, Schuler G, Eitel I. Alteration of multiple leukocyte gene expression networks is linked with magnetic resonance markers of prognosis after acute st-elevation myocardial infarction. <em>Scientific Reports</em>. 2017;7:41705</p> <p>2) Toma A, dos Santos C, Burzyńska B, Góra M, Kiliszek M, Stickle N, Kirsten H, Kosyakovsky L, Wang B, van Diepen S, Epelman S, Szekely Y, Marshall JC, Billia F, Lawler PR (2022), Diversity in the Expressed Genomic Host Response to Myocardial Infarction, submitted.</p>
Instantaneous In Vivo Imaging of Acute Myocardial Infarct by NIR‐II Luminescent Nanodots
<p>Fast and precise localization of ischemic tissues in the myocardium after an acute infarct is required by clinicians as the first step toward accurate and efficient treatment. Nowadays, diagnosis of a heart attack at early times is based on biochemical blood analysis (detection of cardiac enzymes) or by ultrasound‐assisted imaging. Alternative approaches are investigated to overcome the limitations of these classical techniques (time‐consuming procedures or low spatial resolution). As occurs in many other fields of biomedicine, cardiological preclinical imaging can also benefit from the fast development of nanotechnology. Indeed, bio‐functionalized near‐infrared‐emitting nanoparticles are herein used for in vivo imaging of the heart after an acute myocardial infarct. Taking advantage of the superior acquisition speed of near‐infrared fluorescence imaging, and of the efficient selective targeting of the near‐infrared‐emitting nanoparticles, in vivo images of the infarcted heart are obtained only a few minutes after the acute infarction event. This work opens an avenue toward cost‐effective, fast, and accurate in vivo imaging of the ischemic myocardium after an acute infarct.</p>
ADIPOQ Gene Variants (rs266729, rs2241766, rs1501299) and Acute Myocardial Infarction in Vietnamese Patients with Type 2 Diabetes Mellitus
<p>This data is from a study project about ADIPOQ Gene Variants (rs266729, rs2241766, rs1501299) and Acute Myocardial Infarction in Vietnamese Patients with Type 2 Diabetes Mellitus. The data contains information from 550 patients with their identification removed to ensure confidentiality.</p>
Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations
<p>This dataset includes the meshes, model parameters, and Alya executable binary for simulating acute and chronic stage post-myocardial infarct using Alya, to replicate the results in the article <a href="https://doi.org/10.7554/eLife.93002.1">https://doi.org/10.7554/eLife.93002.1</a></p> <p>For each scenario simulated, a baseline simulation folder is provide with all the required meshes, fields, and model parameters necessary to run an Alya simulation. An additional series of models with variability in ionic conductances is also included for each scenario under the folder <scenario>_pom/, under which 20 simulations are included. For each simulation, only the file describing the ionic conductance scaling factors (ventricular_cell.txt) are included, all other files required to run each particular simulation can be found in the <scenario>_baseline/ version. </p> <p>The file structure is as follows:</p> <ul> <li>Alya executable binary</li> <li>control_baseline</li> <li>control_pom</li> <li>75%_transmural_scar <ul> <li>acute <ul> <li>bz1_baseline</li> <li>bz1_pom <ul> <li>pom_id_0</li> <li>...</li> <li>pom_id_19</li> </ul> </li> <li>bz2_baseline</li> <li>bz2_pom <ul> <li>pom_id_0</li> <li>...</li> <li>pom_id_19</li> </ul> </li> <li>bz3_baseline</li> <li>bz3_pom <ul> <li>pom_id_0</li> <li>...</li> <li>pom_id_19</li> </ul> </li> </ul> </li> <li>chronic <ul> <li>rz1_baseline</li> <li>rz1_pom <ul> <li>pom_id_0</li> <li>...</li> <li>pom_id_19</li> </ul> </li> <li>rz2_baseline</li> <li>rz2_pom <ul> <li>pom_id_0</li> <li>...</li> <li>pom_id_19</li> </ul> </li> </ul> </li> <li>fast_pacing <ul> <li>alternans1</li> <li>alternans4</li> </ul> </li> </ul> </li> </ul> <p>The simulation files in alternans4/ was use to generate results Figure 6 of the accompanying article, and alternans1/ was used to generate results Figure 7. </p> <p>The Alya executable binary has been built on ARCHER2 with the following loaded modules:</p> <p>1) craype-x86-rome <br>2) libfabric/1.12.1.2.2.0.0<br>3) craype-network-ofi <br>4) perftools-base/22.12.0 <br>5) xpmem/2.5.2-2.4_3.30__gd0f7936.shasta <br>6) bolt/0.8 <br>7) epcc-setup-env <br>8) load-epcc-module <br>9) gcc/11.2.0 <br>10) craype/2.7.19 <br>11) cray-dsmml/0.2.2 <br>12) cray-mpich/8.1.23 <br>13) cray-libsci/22.12.1.1 <br>14) PrgEnv-gnu/8.3.3 <br>15) tk/8.6.13 <br>16) tcl/8.6.13 <br>17) cray-python/3.9.13.1<br>18) matplotlib/3.7.2<br><br>To replicate the study, access to an installation of the code in the Nord supercomputer can be requested to <a title="mailto:mariano@elem.bio" href="mailto:mariano@elem.bio">mariano@elem.bio</a></p>
Synthetic recovery of impulse propagation in myocardial infarction via silicon carbide semiconductive nanowires
<p><strong> DataSet for the publication "Synthetic recovery of impulse propagation in myocardial infarction via silicon carbide semiconductive nanowires"</strong></p> <p>Pre-processed Confocal data for Figure 3 and Supplementary Figure 3. Acquired with Leica SP8 Laser-Scanning Confocal Microscope</p> <p>Pre-processed HPICM raw data for Figure 2, Supplementary Figure 2 Acquired with Ionscope Hopping Software</p> <p>Pre-processed double-patch clamp data for Figure 2b-c. Acquired with Clampfit 10.6</p> <p>Pre-processed EP raw data for Figure 6-7-8, supplementary Figure 4. Acquired with Clampfit 10.6</p> <p>Post-processed Kinematic trajectories for Supplementary Figure 5, Supplementary Figure 6 acquired with Video Spot Tracker V 8.00</p> <p> </p> <p> </p> <p> </p>
Intracellular delivery of nitric oxide enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction
<p>Cell therapy by autologous mesenchymal stem cells (MSCs) is a clinically acceptable strategy for treating various diseases. Unfortunately, the therapeutic efficacy is largely affected by the low quality of MSCs collected from patients. Herein, we showed that the gene expression of MSCs from patients with diabetes was differentially regulated compared to that of MSCs from healthy controls. Then, MSCs were genetically engineered to catalyse an NO prodrug to release NO intracellularly. Compared to extracellular NO conversion, intracellular NO delivery effectively prolonged survival and enhanced the paracrine function of MSCs, as demonstrated by in vitro and in vivo assays. The enhanced therapeutic efficacy of engineered MSCs combined with intracellular NO delivery was further confirmed in mouse and rat models of myocardial infarction, and a clinically relevant cell administration paradigm through secondary thoracotomy has been attempted.</p>
Raw Data - Part 2 : Spatial multi-omic map of human myocardial infarction
<p>We provide here the raw data of snATAC-seq and snRNA-seq for the manuscript: Kuppe, Ramirez Flores, Li et al. "Spatial multi-omic map of human myocardial infarction", 2022</p>
Raw Data - Part 4 : Spatial multi-omic map of human myocardial infarction ---- Raw image
<p>We provide here the raw image for the visium data for the manuscript: Kuppe, Ramirez Flores, Li et al. "Spatial multi-omic map of human myocardial infarction", 2022</p>
Unravelling pain in Göttingen Minipigs undergoing experimentally induced closed-chest myocardial infarction.
<p>This file contains mechanical and thermal pain thresholds recorded in adult Göttingen Minipigs before and after experimentally induced myocardial infarction. </p> <p>Mechanical thresholds were recorded with a manual algometer (tip size 1 cm2); thermal thresholds consisted in heat contact stimuli. Thresholds were recorded at different body sites, namely: LC: left chest; RC: right chest; LF: left forearm; RF: right forearm; LN: left neck; RN: right neck. </p> <p>The Excel file also provides demographic data, physiological parameters (heart rate and respiratory rate), biomarkers (troponin I and cytokines), and feasibility scores. </p> <p> </p>
3D bioprinted alginate-gelatin hydrogel patches containing cardiac spheroids recover heart function in a mouse model of myocardial infarction
<p>Datasets for Roche et al (2023), '3D bioprinted alginate-gelatin hydrogel patches containing cardiac spheroids recover heart function in a mouse model of myocardial infarction'.</p>
The INFUSE - Anterior Myocardial Infarction (AMI) Study
ClinicalTrials.gov study NCT00976521. IPD Sharing: Not stated. Countries: 6. Publications: 8.
Cangrelor in ST-Elevation Myocardial Infarction to Decrease Infarct Size
ClinicalTrials.gov study NCT03043274. IPD Sharing: NO. Countries: 1. Publications: 6.
Single Catheter Primary Percutaneous Coronary Intervention Method in Patients With ST Elevation Myocardial Infarction
ClinicalTrials.gov study NCT05604976. IPD Sharing: NO. Countries: 1. Publications: 7.
Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction
ClinicalTrials.gov study NCT05462730. IPD Sharing: NO. Countries: 1. Publications: 2.
HMO Research Network CERT: Acute Myocardial Infarction
ClinicalTrials.gov study NCT00211172. IPD Sharing: Not stated. Countries: 1. Publications: 1.
CMR in Myocardial Infarction with Nonobstructive Coronary Arteries
ClinicalTrials.gov study NCT06502899. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Effects of Recombinant Human Erythropoietin on Platelet Function in Patients With Acute Myocardial Infarction
ClinicalTrials.gov study NCT00367991. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Evaluate the Safety and Efficacy of MEDI6012 in Acute ST Elevation Myocardial Infarction
ClinicalTrials.gov study NCT03578809. IPD Sharing: YES. Countries: 10. Publications: 1.
CARISMA : Cardiac Arrhythmias and Risk Stratification After MyoCardial Infarction
ClinicalTrials.gov study NCT00145119. IPD Sharing: Not stated. Countries: 1. Publications: 9.
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OpenNeuro
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