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186
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Dataset results
186 results for “Insulin secretion”
Effects of Nateglinide on Postprandial Glucose Excursion by Restoring Early Phase Insulin Secretion
ClinicalTrials.gov study NCT01030952. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Effect of Banaba (Lagerstroemia Speciosa) on Metabolic Syndrome, Insulin Secretion and Insulin Sensitivity
ClinicalTrials.gov study NCT02767869. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Beneficial Effect of Salicylates: Insulin Action, Secretion or Clearance?
ClinicalTrials.gov study NCT02007577. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion
ClinicalTrials.gov study NCT02114892. IPD Sharing: Not stated. Countries: 1. Publications: 27.
Pantoprazole on Insulin Secretion in Diabetes
ClinicalTrials.gov study NCT01541735. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Glutamine on GLP-1 and Insulin Secretion in Man
ClinicalTrials.gov study NCT00673894. IPD Sharing: NO. Countries: 1. Publications: 3.
Effect of Dapagliflozin Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion
ClinicalTrials.gov study NCT02113241. IPD Sharing: Not stated. Countries: 1. Publications: 14.
Effect of Fucoxanthin on the Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion
ClinicalTrials.gov study NCT03613740. IPD Sharing: NO. Countries: 1. Publications: 2.
FrexalimAB in Preservation of Endogenous insULIN Secretion Compared to Placebo in adUlts and Adolescents on Top of inSulin Therapy (FABULINUS)
ClinicalTrials.gov study NCT06111586. IPD Sharing: YES. Countries: 16. Publications: 0.
Insulin Secretion in Diabetes Before and After Glycemic Control
ClinicalTrials.gov study NCT00469833. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: ApoA-I protects pancreatic β-cells from cholesterol-induced mitochondrial damage and restores their ability to secrete insulin
Open the record for dataset details and reuse information.
Thiazides attenuate insulin secretion through inhibition of mitochondrial carbonic anhydrase 5b in β-islet cells in mice
<p><span><em><strong>Background</strong></em>:</span><span> Thiazides </span><span>are associated with glucose intolerance and new onset diabetes mellitus. Previous studies demonstrated that thiazides attenuate insulin secretion, but the molecular mechanisms remain elusive. We hypothesized that thiazides attenuate insulin secretion via one of the known molecular thiazide targets</span> <span>in β-cells.</span></p> <p><span><em><strong>Methods</strong></em>:</span><span> We performed static insulin secretion experiments with islets of wild-type, NCC (SLC12A3) and NDCBE (SLC4A8) knock-out (KO) mice and with murine Min6 cells with individual knock-down of carbonic anhydrase (CA) isoforms to identify the molecular target of thiazides in </span><span>β-cells</span><span>. CA5b KO mice were then used to assess the role of the putative thiazide target CA5b in </span><span>β-cell </span><span>function and in mediating thiazide sensitivity<em> in vitro</em> and<em> in vivo</em>.</span></p> <p><span><em><strong>Results</strong></em>:</span><span> Thiazides inhibited glucose- and sulfonylurea-stimulated insulin secretion in islets and Min6 cells at pharmacologically relevant concentrations.</span> <span>Inhibition of insulin secretion by thiazides was CO2/HCO3--dependent, not additive to unselective CA inhibition with acetazolamide and independent of extracellular potassium. In contrast, insulin secretion was unaltered in islets of mice lacking the known molecular thiazide targets NCC or NDCBE. CA expression profiling with subsequent knock-down of individual CA isoforms suggested mitochondrial CA5b as molecular target.</span><span> In support of these findings, thiazides significantly attenuated Krebs cycle anaplerosis through reduction of mitochondrial oxaloacetate synthesis</span><span>. </span><span>CA5b KO mice were resistant to thiazide-induced glucose intolerance, and thiazides did not alter insulin secretion in CA5b KO islets. </span></p> <p><span><em><strong>Conclusions</strong></em>:</span><span> In summary, our study reveals that thiazides attenuate insulin secretion via inhibition of the mitochondrial CA5b isoform in </span><span>β</span><span>-cells.</span></p>
Fig. 3 in Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk
Fig. 3. Effects of test compounds (from Clutia lanceoleta) on the glucose-triggered secretion of insulin from murine islets. Islets were incubated for 1 h at 37 °C in KRB buffer containing glucose (16.7 mM) in the absence (Control) or presence of test compounds and the secreted insulin was measured. Values are mean ± SD from three independent experiments. *P <0.05, **P <0.01, ***P <0.001 compared with the control value.
Fig. 2. X-Ray crystal structures determined for 1,8,9,11,12,14–17,19,20 in Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk
Fig. 2. X-Ray crystal structures determined for 1,8,9,11,12,14–17,19,20. Atoms are shown as thermal ellipsoids drawn at the 50% probability level.
Fig. 1 in Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk
Fig. 1. Structures of 5-methylcoumarins isolated from Clutia lanceolata. Compounds 1–13 are undescribed, whereas 14–21 are known but are isolated from this plant for the first time. Also shown is the chemical numbering scheme for the ring and its substituents.
Effect of Celery Seed on the Components of Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion
ClinicalTrials.gov study NCT06061926. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Postprandial Insulin Secretion and Appetite Regulation After Moderate Alcohol Consumption
ClinicalTrials.gov study NCT00524550. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Defining the Decline in Endogenous Insulin Secretion in Type 1 Diabetes Diagnosed After 30 Years of Age.
ClinicalTrials.gov study NCT04682457. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
The Reduction in Glucose Stimulated Insulin Secretion Induced by Cytokines May be Prevented by Copper Addition - Studies in Diabetic Patients
ClinicalTrials.gov study NCT00846144. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Chronic Reduction of Fasting Glycaemia With Insulin Glargine Improves First and Second Phase Insulin Secretion in Patients With Type 2 Diabetes
ClinicalTrials.gov study NCT01249677. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.