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25 results for “Insulin-like growth factor 1”
In vivo treatment with insulin-like growth factor 1 reduces CCR5 expression on vaccine-induced activated CD4+ T-cells
<p>Dataset of the publication "In vivo treatment with insulin-like growth factor 1 reduces CCR5 expression on vaccine-induced activated CD4+ T-cells" by Bissa et al. on the journal Vaccines. </p><p>Each folder contains the original files reporting the data used to generate the manuscript.</p><p>For flowcytometry based assays the Flow panel is included in the folders. </p><p>For ELISA based assays the schemes of the plates are included in the folders. </p><p>The excel table "Bissa et al._Vaccines_2023_Animal IDs and viral acquisition" reports the IDs and grouping of the animals together with their viral acquisition</p><p>The excel table "Bissa et al._Vaccines_2023_Master table" reports each data used to generate the figures and supplemental materials included in the publication </p>
New protein production in primary pulmonary artery endothelial cells treated with insulin-like growth factor 1 treatment
<p>Maximum projections of flat-fielded and deconvolved epi-fluorescence imaging data for primary sheep pulmonary artery endothelial cells (PAEC) treated with vehicle or insulin-like growth factor 1 (IGF1) media.</p> <p>Two cell types: normal PAEC and persistent pulmonary hypertension of the newborn (PPHN) PAEC</p> <p>Three time points: 0 minutes, 1 hour, and 24 hours post-treatment</p> <p>Two fluorescence channels:<br> C0 - DAPI for nuclei (R37606, Life Technologies)<br> C1 - Click-IT new protein translation kit (C10428, C10429, Life Technologies)</p>
Insulin-like Growth Factor 1 Receptor (IGF-1R) Antibody AMG479 (Ganitumab) in Combination With the Src Family Kinase (SFK) Inhibitor Dasatinib in People With Embryonal and Alveolar Rhabdomyosarcoma
ClinicalTrials.gov study NCT03041701. IPD Sharing: YES. Countries: 1. Publications: 1.
Effects of SomatoKine (Iplex)Recombinant Human Insulin-like Growth Factor-1/Recombinant Human Insulin-like Growth Factor-binding Protein-3 (rhIGF-I/rhIGFBP-3) in Myotonic Dystrophy Type 1 (DM1)
ClinicalTrials.gov study NCT00233519. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Insulin-like growth factor 1 and life-history evolution of passerine birds
1. Natural selection has generated a diversity of ways in which vertebrates allocate their resources between fundamental life-history traits. The availability of possible evolutionary trajectories of these traits is limited by various genetic, physiological, and phylogenetic constraints. This causes trade-offs due to shared resource pools for, or genetic linkage of, competing traits. The majority of these trade-offs are mediated by hormones and create the variability of phenotypes that can be observed in nature. 2. Insulin-like growth factor 1 (IGF-1) is an evolutionarily conserved peptide, which has been shown to be essential in the regulation of body size, the pattern of reproductive investment and lifespan across a broad taxonomic range of model species in laboratory and domesticated conditions. However, studies addressing corresponding evolutionary hypotheses on a broader scale and in free-living vertebrates are very rare. 3. In this phylogenetic comparative study on free-living passerines (Passeriformes), we explore the way in which plasma IGF-1 levels underlie the evolution of body size and demographic fitness correlates (clutch size, egg weight, lifespan). 4. We showed firstly that IGF-1 levels were positively associated with the body size of passerines, although smaller birds had larger IGF-1-mediated investment into building up their body faster. IGF-1 levels were negatively associated with lifespan of passerines, and more so in birds with smaller body weight. Finally, IGF-1 levels were negatively associated with clutch size in heavier species, and positively associated with egg weight in species with higher body weight and longer duration of parental care. The pattern was opposite in species with smaller body weight and shorter duration of parental care. 5. The described evolutionary framework indicates that variation in IGF-1 levels can be regarded as an important mechanism that may underlie life-history evolution in passerines. IGF-1 could act as a physiological link mediating the inter-regulatory growth–reproduction–lifespan "life-history triangle" on the pace-of-life continuum. Interestingly, body weight and investment into parental care have likely imposed a constraining effect on the IGF-1-mediated co-evolution of demographic fitness traits, such as lifespan or reproductive investment. This has limited the availability of adaptive pathways via which those traits could evolve as passerines diversified.
Establishment of Reference Values for Insulin-like Growth Factor 1 (IGF1) in the General Population
ClinicalTrials.gov study NCT01831648. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Data from: Insulin-like growth factor 1 and life-history evolution of passerine birds
Open the record for dataset details and reuse information.
Data from: Causal link between insulin-like growth factor 1 and growth in nestlings of a wild passerine bird
Open the record for dataset details and reuse information.
The Association Between Diabetes Mellitus, Oral Lichen Planus and Insulin-like Growth Factors 1 and 2 (IGF1 and IGF2)
ClinicalTrials.gov study NCT03257228. IPD Sharing: NO. Countries: 0. Publications: 3.
Safety and Efficacy Study of Recombinant Human Insulin-Like Growth Factor-I/Recombinant Human Insulin-Like Growth Factor Binding Protein-3 (rhIGF-I/rhIGFBP-3) In Myotonic Dystrophy Type 1
ClinicalTrials.gov study NCT00577577. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Platelet-secreted microRNA-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting the insulin-like growth factor 1 receptor
GEO Series GSE51453. Homo sapiens. 2 samples. Type: Expression profiling by RT-PCR.
A distal super enhancer mediates estrogen-dependent mouse uterine–specific gene transcription of Insulin-like growth factor 1 (Igf1)
GEO Series GSE125972. Mus musculus. 38 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Genome-wide analysis of insulin-like growth factor 1 receptor (IGF1R) binding sites in DFB cells
GEO Series GSE23792. Homo sapiens. 1 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Identification of pro-metastatic pathways and molecules in mouse models with reduced expression or signaling of the insulin-like growth factor type 1 receptor
GEO Series GSE182236. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Single Cell Landscape of Left Atria Reveals Amphiregulin and Insulin-like Growth Factor 1 as Surrogate Markers in Patients with Atrial Fibrillation.
GEO Series GSE261170. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Microvascular smooth muscle cells exhibit divergent phenotypic switching responses to platelet-derived growth factor and insulin-like growth factor 1
GEO Series GSE312686. Rattus norvegicus. 9 samples. Type: Expression profiling by high throughput sequencing.
The role of miRNAs and lncRNAs in regulating transcription in gilthead sea bream (Sparus aurata) myoblasts in response to amino acids and insulin-like growth factor 1 [RNA-seq]
GEO Series GSE246573. Sparus aurata. 9 samples. Type: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Targeting Insulin-Like Growth Factor 1 Receptor Restricts Development and Severity of Secondary Lymphedema in Mice
GEO Series GSE256205. Mus musculus. 8 samples. Type: Expression profiling by array.
The effect of insulin-like growth factor 1 and insulin on neutrophil polarization
GEO Series GSE198319. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
The role of miRNAs and lncRNAs in regulating transcription in gilthead sea bream (Sparus aurata) myoblasts in response to amino acids and insulin-like growth factor 1
GEO Series GSE246665. Sparus aurata. 18 samples. Type: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.