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datasets available to search
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Dataset results
16 results for “Lp-PLA2”
Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Progenitor Cells and Coronary Atherosclerosis in Humans
ClinicalTrials.gov study NCT01067339. IPD Sharing: NO. Countries: 1. Publications: 1.
Impact of an 8-week Linoleic Acid Intake in Soy Oil on Lp-PLA2 Activity in Healthy Adults
ClinicalTrials.gov study NCT02753907. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Lp-PLA2 and dual antiplatelet agents in intracranial arterial stenosis
Objective: To evaluate the interaction effect of lipoprotein-associated phospholipase A2 (Lp-PLA2) activity on the efficacy and safety of dual/single antiplatelet therapy in patients with and without intracranial arterial stenosis (ICAS) by the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial. Methods: Subjects with both MR imaging analysis and Lp-PLA2 testing results were included in the current subanalysis. The interaction of Lp-PLA2 activity with the effects of dual and single antiplatelet therapy were analyzed through cox proportional hazards regressions model. Results: Among the 797 patients, the mean age was 63.1±10.8 years, 518 (65%) were men, 356 (44.7%) patients had ICAS and 441 (55.3%) did not. There are significantly more patients with elevated Lp-PLA2 activity in the ICAS group than that in the non-ICAS group (43.8% versus 35.4%, p=0.02). There was significant interaction between Lp-PLA2 activity levels and the two antiplatelet therapy for prevention of stroke recurrences and combined vascular events even after adjustment for confounding factors exclusively for patients with ICAS (p=0.016, 0.016, respectively), but not for those without (p=0.289, 0.597, respectively). Compared with aspirin alone, dual antiplatelet therapy significantly reduced the risk of stroke recurrences and combined vascular events (adjusted hazard ratio=0.33 [0.12-0.88], p=0.026; 0.33 [0.12-0.88], p=0.026, respectively) for patients with both ICAS and non-elevated Lp-PLA2 activity. Conclusions: Presence of both ICAS and non-elevated Lp-PLA2 activity may predict better response to dual antiplatelet therapy in prevention of recurrent strokes and combined vascular events for patients with minor stroke or high-risk TIA.
Figure 3 from: Nafisah W, Dalilati AZ, Christina YI, Atho'illah MF, Rifa'ia M, Noor TNETA, Nugraha AP (2024) Amstirdam coffee ameliorates Lp-PLA2 and the inflammatory response in an atherosclerosis rats. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e106817
Figure 3 ACE administration increased the level of regulatory T cells in mice fed a high-fat, high-fructose diet for 5 months. The level of regulatory T cell A. CD4+CD25+CD62L+ subsets, B. CD4+CD25+IL-10+ subsets, and C. CD4+CD25+TGF-+subsets of mice fed with HFFD and administration of ACE from flow cytometry analysis. The percentage of regulatory T cell D. CD4+CD25+CD62L+ subsets, E. CD4+CD25+IL-10+ subsets, and F. CD4+CD25+TGF-+ subsets of mice fed with HFFD and administered ACE The data are mean SD (n = 5). N: normal-fed mice (non-high-fat-fructose diet); HFFD: high-fat-fructose diet mice (w/o administration of ACE); D1: HFFD mice receiving ACE 104 mg/kg body weight; D2: HFFD mice receiving ACE 520 mg/kg body weight; D3: HFFD mice receiving ACE 5200 mg/kg body weight. The different notation on the chart was considered significantly different for each group at p<0.05 and vice versa on the DMRT post hoc test.
Figure 5 from: Nafisah W, Dalilati AZ, Christina YI, Atho'illah MF, Rifa'ia M, Noor TNETA, Nugraha AP (2024) Amstirdam coffee ameliorates Lp-PLA2 and the inflammatory response in an atherosclerosis rats. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e106817
Figure 5 The effect of ACE increased TGF-β production (CD4+TGF-β+) in mice fed with a high fat-fructose diet for 5 months. The expression of TGF-β (CD4+TGF-β+) of mice fed with HFFD and administration of ACE from flow cytometry analysis (Fig. 5G). The percentage of regulatory (CD4+IL-10+) of mice fed with HFFD and administration of ACE (Fig. 5H). Data are mean ± SD (n=5). N: normal fed mice (non-high fat-fructose diet), HFFD: high fat-fructose diet mice (w/o administration of ACE), D1: HFFD mice receiving ACE 104 mg/kg body weight, D2: HFFD mice receiving ACE 520 mg/kg BW, D3: HFFD mice receiving ACE 5200 mg/kg BW. The different notation on the chart was considered significantly different for each group at p < 0.05 and vice versa on DMRT post hoc test.
Figure 2 from: Nafisah W, Dalilati AZ, Christina YI, Atho'illah MF, Rifa'ia M, Noor TNETA, Nugraha AP (2024) Amstirdam coffee ameliorates Lp-PLA2 and the inflammatory response in an atherosclerosis rats. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e106817
Figure 2 ACE administration reduced foam cells in aorta histopathology (M = 400×) in mice fed a high-fat, high-fructose diet for 5 months. The black arrow shows the accumulation of foam cells in the tunica media, and the asterisk (*) shows the lumen of the aorta. N: normal-fed mice (non-high-fat-fructose diet); HFFD: high-fat-fructose diet mice (w/o administration of ACE); D1: HFFD mice receiving ACE 104 mg/kg body weight; D2: HFFD mice receiving ACE 520 mg/kg body weight; D3: HFFD mice receiving ACE 5200 mg/kg body weight.
Figure 1 from: Nafisah W, Dalilati AZ, Christina YI, Atho'illah MF, Rifa'ia M, Noor TNETA, Nugraha AP (2024) Amstirdam coffee ameliorates Lp-PLA2 and the inflammatory response in an atherosclerosis rats. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e106817
Figure 1 Reduction of Lp-PLA2 production after ACE treatment in mice fed a high-fat, high-fructose diet. The expression of Lp-PLA2 production in mice fed with HFFD and administered ACE was determined from flow cytometry analysis (Fig. 1A). The percentage of Lp-PLA2 production in mice fed with HFFD and administered ACE The data are mean SD (n = 5). N: normal-fed mice (non-high-fat-fructose diet); HFFD: high-fat-fructose diet mice (w/o administration of ACE); D1: HFFD mice receiving ACE 104 mg/kg body weight; D2: HFFD mice receiving ACE 520 mg/gram BW; D3: HFFD mice receiving ACE 5200 mg/kg BW. The different notation on the chart was considered significantly different for each group at p< 0.05 and vice versa on the DMRT post hoc test.
Figure 4 from: Nafisah W, Dalilati AZ, Christina YI, Atho'illah MF, Rifa'ia M, Noor TNETA, Nugraha AP (2024) Amstirdam coffee ameliorates Lp-PLA2 and the inflammatory response in an atherosclerosis rats. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e106817
Figure 4 Administration of ACE increased IL-10 production (CD4+IL-10+) in mice fed with a high-fat, high-fructose diet for 5 months. The expression of CD4+IL-10+ in mice fed with HFFD and administered ACE was determined by flow cytometry analysis (Fig. 4E). The percentage of regulatory cells (CD4+IL-10+) in mice fed with HFFD and administered ACE (Fig. 4F) The data are mean SD (n = 5). N: normal-fed mice (non-high-fat-fructose diet); HFFD: high-fat-fructose diet mice (w/o administration of ACE); D1: HFFD mice receiving ACE 104 mg/kg body weight; D2: HFFD mice receiving ACE 520 mg/kg body weight; D3: HFFD mice receiving ACE 5200 mg/kg body weight. The different notation on the chart was considered significantly different for each group at p < 0.05 and vice versa on the DMRT pos hoc test.
Blood Pressure Lowering Effect of Supplementation With Korea Red Ginseng Associated With Reductions in Circulating Lp-PLA2 Activity and Lysophospatidylcholines and an Increase in Dihydrobiopterin in P
ClinicalTrials.gov study NCT02326766. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Serum Lipid Levels and Lp-PLA2 in Chronic Periodontitis
ClinicalTrials.gov study NCT03041480. IPD Sharing: NO. Countries: 0. Publications: 2.
Data from: Lp-PLA2 and dual antiplatelet agents in intracranial arterial stenosis
Open the record for dataset details and reuse information.
Lp-PLA2 and Coronary Atherosclerosis in Humans
ClinicalTrials.gov study NCT01557088. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ST Elevation in Acute Chest Pain; Could Measurement of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) be Helpful to the Clinician?
ClinicalTrials.gov study NCT01041339. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dietary Effects on Circulating Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Activity and Enzyme Activity in Peripheral Blood Mononuclear Cells (PBMCs) in Patients With Prediabetes or Newly Diagno
ClinicalTrials.gov study NCT01895387. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Contribution of Lp-PLA2 Level to the Presence of Coronary Plaques in Patients With Non Alcoholic Fatty Liver Disease
ClinicalTrials.gov study NCT01139632. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Changes in Body Adiposity by Dual Probiotic Strains Positively Correlated With Changes in Lp-PLA2 Activity in Overweight Adults
ClinicalTrials.gov study NCT02492698. IPD Sharing: Not stated. Countries: 0. Publications: 0.
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