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20 results for “MOG”
Data from: International multicenter examination of MOG antibody assays.
<div> <div> <div>Raw data set for:</div> </div> <p><strong>Reindl M, Schanda K, Woodhall M, Tea F, Ramanathan S, Sagen J, Fryer JP, Mills J, Teegen B, Mindorf S, Ritter N, Krummrei U, Stöcker W, Eggert J, Flanagan EP, Ramberger M, Hegen H, Rostasy K, Berger T, Leite MI, Palace J, Irani SR, Dale RC, Probst C, Probst M, Brilot F, Pittock SJ, Waters P. <a href="https://www.ncbi.nlm.nih.gov/pubmed/32024795/">International multicenter examination of MOG antibody assays. </a>Neurol Neuroimmunol Neuroinflamm. 2020 Mar 5;7(2). doi: 10.1212/NXI.0000000000000674. Print 2020 Mar 5. PubMed PMID: 32024795; PubMed Central PMCID: PMC7051197.</strong></p> </div> <div> <div> <p> </p> <p><strong>Objective: </strong>To compare the reproducibility of 11 antibody assays for immunoglobulin (Ig) G and IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG and MOG-IgM) from 5 international centers.</p> <p><strong>Methods: </strong>The following samples were analyzed: MOG-IgG clearly positive sera (n = 39), MOG-IgG low positive sera (n = 39), borderline negative sera (n = 13), clearly negative sera (n = 40), and healthy blood donors (n = 30). As technical controls, 18 replicates (9 MOG-IgG positive and 9 negative) were included. All samples and controls were recoded, aliquoted, and distributed to the 5 testing centers, which performed the following antibody assays: 5 live and 1 fixed immunofluorescence cell-based assays (CBA-IF, 5 MOG-IgG, and 1 MOG-IgM), 3 live flow cytometry cell-based assays (CBA-FACS, all MOG-IgG), and 2 ELISAs (both MOG-IgG).</p> <p><strong>Results: </strong>We found excellent agreement (96%) between the live CBAs for MOG-IgG for samples previously identified as clearly positive or negative from 4 different national testing centers. The agreement was lower with fixed CBA-IF (90%), and the ELISA showed no concordance with CBAs for detection of human MOG-IgG. All CBAs showed excellent interassay reproducibility. The agreement of MOG-IgG CBAs for borderline negative (77%) and particularly low positive (33%) samples was less good. Finally, most samples from healthy blood donors (97%) were negative for MOG-IgG in all CBAs.</p> <p><strong>Conclusions: </strong>Live MOG-IgG CBAs showed excellent agreement for high positive and negative samples at 3 international testing centers. Low positive samples were more frequently discordant than in a similar comparison of aquaporin-4 antibody assays. Further research is needed to improve international standardization for clinical care.</p> <p> </p> <p> </p> </div> </div>
A Study to Evaluate the Efficacy and Safety of Rozanolixizumab in Adult Participants With Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Disease (MOG-AD)
ClinicalTrials.gov study NCT05063162. IPD Sharing: YES. Countries: 21. Publications: 1.
UU1874-44885 - Groot placaet-boeck, vervattende de placaten, ordonnantien ende edicten van de doorluchtige, hoogh mog. heeren Staten Generael der Vereenighde Nederlanden ende vande ed. groot-mog. heeren Staten van Hollandt en West-Vrieslandt, mitsgaders vande ed. mog. heeren Staten van Zeelandt (Volume 2)
<p>Titel: <em> </em><em>Groot placaet-boeck, vervattende de placaten, ordonnantien ende edicten van de doorluchtige, hoogh mog. heeren Staten Generael der Vereenighde Nederlanden ende vande ed. groot-mog. heeren Staten van Hollandt en West-Vrieslandt, mitsgaders vande ed. mog. heeren Staten van Zeelandt </em><em> </em><em> </em><em>(Volume </em><em>2</em><em>)</em></p> <p>Publisher: weduwe ende erfgenamen van wylen Hillebrandt Jacobsz van Wouw</p> <p>Place: ‘s-Gravenhage</p> <p>Year: 1664</p> <p>Used version: The copy we used for the transcriptions is held at Utrecht University.</p> <p>Link digitised version of the book: http://objects.library.uu.nl/reader/index.php?obj=1874-44885&amp;lan=nl</p> <p> </p> <p>(Main) Language: Dutch.</p> <p>Province: Holland, West-Friesland and Zeeland.</p> <p>Font: Roman.</p> <p>Model used: Dutch_Romanprint_Print</p> <p>Version of Transkribus used: v.1.9.1.</p> <p>Other info: Abbyy FineReader v.11 has been used.</p> <p>Link model: For more information on the HTR-model used, please visit: <a href="https://lab.kb.nl/dataset/entangled-histories-ordinances-low-countries">https://lab.kb.nl/dataset/entangled-histories-ordinances-low-countries</a>.</p> <p>Transcription conventions:</p> <ul> <li> <p>The abbreviations have been written out into full words.</p> </li> <li> <p>The hyphens at the end of a line have been kept (when there).</p> </li> </ul> <p>If you are in need of the original scans of the documents, please contact <a href="mailto:xxxxxx@kb.nl">dataservices@kb.nl</a>.</p> <p>This transcription is part of the dataset created with the ‘Entangled Histories’-project.</p> <p>PI: dr. C.A. Romein;<br> Scientific Programmer: S.F. Veldhoen, MSc;<br> Project Manager: drs. M. de Gruijter.</p> <p> </p>
UU15755 - Groot placaet-boeck, vervattende de placaten, ordonnantien ende edicten van de doorluchtige, hoogh mog. heeren Staten Generael der Vereenighde Nederlanden ende vande ed. groot-mog. heeren Staten van Hollandt en West-Vrieslandt, mitsgaders vande ed. mog. heeren Staten van Zeelandt (Volume 8)
<p>Titel: <em> </em><em>Groot placaet-boeck, vervattende de placaten, ordonnantien ende edicten van de doorluchtige, hoogh mog. heeren Staten Generael der Vereenighde Nederlanden ende vande ed. groot-mog. heeren Staten van Hollandt en West-Vrieslandt, mitsgaders vande ed. mog. heeren Staten van Zeelandt </em><em>(Volume 8)</em></p> <p>Publisher: Johannes Allart</p> <p>Place: Amsterdam</p> <p>Year: 1795</p> <p>Used version: The copy we used for the transcriptions is held at the KB National Library of the Netherlands.</p> <p>Link digitised version of the book: http://objects.library.uu.nl/reader/index.php?obj=1874-187398&amp;lan=nl</p> <p>(Main) Language: Dutch.</p> <p>Province: Holland, West-Friesland and Zeeland.</p> <p>Font: Roman.</p> <p>Model used: Dutch_Romanprint_Print</p> <p>Version of Transkribus used: v.1.9.1.</p> <p>Other info: Abbyy FineReader v.11 has been used.</p> <p>Link model: For more information on the HTR-model used, please visit: <a href="https://lab.kb.nl/dataset/entangled-histories-ordinances-low-countries">https://lab.kb.nl/dataset/entangled-histories-ordinances-low-countries</a>.</p> <p>Transcription conventions:</p> <ul> <li> <p>The abbreviations have been written out into full words.</p> </li> <li> <p>The hyphens at the end of a line have been kept (when there).</p> </li> </ul> <p>If you are in need of the original scans of the documents, please contact <a href="mailto:xxxxxx@kb.nl">dataservices@kb.nl</a>.</p> <p>This transcription is part of the dataset created with the ‘Entangled Histories’-project.</p> <p>PI: dr. C.A. Romein;<br> Scientific Programmer: S.F. Veldhoen, MSc;<br> Project Manager: drs. M. de Gruijter.</p>
Different immunological mechanisms between AQP4-positive and MOG-positive optic neuritis based on RNA-seq analysis of whole blood
GEO Series GSE226808. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Effect of MOG-7 disruption on the C. elegans transcriptome
GEO Series GSE162055. Caenorhabditis elegans. 18 samples. Type: Expression profiling by high throughput sequencing.
RNA seq on SP specific CD8+ T cells, Ly49+ and Ly49-CD8+ T cells from MOG and MOG + SP immunized mice [RNA-Seq]
GEO Series GSE130975. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Evaluation of Two Cell-based Assays for Diagnosing MOG-IgG Associated Disorders
ClinicalTrials.gov study NCT06617962. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Immediate Versus Delayed Treatment With Azathioprine or Rituximab in Anti-MOG Antibodies Associated Acute Demyelinating Syndromes in Children: a Randomized Controlled Clinical Trial
ClinicalTrials.gov study NCT05545384. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Gene expression in brain tissue from MOG-immunized wild-type or C57BL/6Je/e mice at disease maximum.
GEO Series GSE73587. Mus musculus. 8 samples. Type: Expression profiling by array.
RNA seq on SP specific CD8+ T cells, Ly49+ and Ly49-CD8+ T cells from MOG and MOG + SP immunized mice and DNA sequencing for multiple rounds of the pMHC-yeast display selection for TCR6, TCR7 and FluT
GEO Series GSE133364. Mus musculus; synthetic construct. 13 samples. Type: Expression profiling by high throughput sequencing; Other.
MOG-IgG testing strategies in accordance with the 2023 MOGAD criteria: A clinico-laboratory assessment
<p>Introduction</p><p>This database includes the raw data linked with the paper "MOG-IgG testing strategies in accordance with the 2023 MOGAD criteria: A clinico-laboratory assessment " to be published on "Journal of Neurology Neurosurgery and Psychiatry". </p><p>In this paper, we reported clinical, radiological and laboratory data concerning thirty-eight individuals diagnosed with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) to assess the impact of the criteria-based MOG-IgG testing in MOGAD diagnosis. </p><p>Methods</p><p>Thirty-eight serum samples of MOG-IgG1-positive MOGAD patients were titred on MOG-IgG LCBA and FCBA, and the presence of supporting features for MOGAD assessed. MOGAD criteria were evaluated in three testing scenarios: a) FCBA without titration; b) FCBA with titration; c) LCBA with titration.</p><p>Results (in brief)</p><p>FCBA without titration failed to reach MOGAD diagnosis in 11/38 patients (28.9%, negative results in 5, lack of supporting features in 6). Patients with unconfirmed diagnosis had optic neuritis (ON, n=8), or transverse myelitis (TM, n=3). FCBA with titration allowed MOGAD diagnosis in 4 additional patients. Correlation between LCBA and FCBA titres was moderate (Spearman's rho 0.6, p<0.001).</p>
Transcriptome of myelin oligodendrocyte glycoprotein (MOG)-reactive CD4 T cells and control CD4 T cells from draining lymp nodes and spleens of mice during experimental autoimmune encephalomyelitis (E
GEO Series GSE205600. Mus musculus. 15 samples. Type: Expression profiling by array.
Expression data from CD4+ T cells isolated from inguinal lymph nodes 7 days post MOG immunization
GEO Series GSE92680. Rattus norvegicus. 17 samples. Type: Expression profiling by array.
MEaSUREs MODIS Mosaic of Greenland (MOG) 2005, 2010, and 2015 Image Maps V002
This data set, part of the NASA Making Earth System Data Records for Use in Research Environments (MEaSUREs) program, consists of two digital Greenland image maps each for the 2005, 2010, and 2015 measurement periods: the MOG Surface Morphology Image Map and the MOG Grain Size Image Map. The image maps are constructed from MODIS imagery acquired during 2005, 2010, and 2015 and provide nearly cloud-free views of all land areas and islands larger than a few hundred meters, including the ice caps on Baffin Island, Devon Island, Axel Heiberg Island, and Ellesmere Island.
Expression data from splenic T cells at day7 during MOG-induced mouse EAE model
GEO Series GSE197869. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Treatment with nanoliposomes loaded with ITE and MOG(35-55) ameliorates EAE
GEO Series GSE155711. Mus musculus. 60 samples. Type: Expression profiling by high throughput sequencing.
MOG-encoding DNA vaccines ameliorate EAE and display neuroprotective effects in treated mice summary
GEO Series GSE30482. Mus musculus. 10 samples. Type: Expression profiling by array.
MOG KO Tregs versus WT Tregs
GEO Series GSE79124. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Prognostic relevance of quantitative and longitudinal MOG antibody testing in patients with MOGAD: a multicentre retrospective study
<p><strong>Introduction. </strong>The database contains information regarding patients with myelin oligodendrocyte glycoprotein associated disorders (MOGAD), including demographic, clinical presentation and course, neuroradiological data, laboratory data, treatment and outcome data and data regarding antibody titres over time.</p> <p><strong>Methods. </strong>In this retrospective multicentre Italian cohort study, we recruited patients with MOGAD and available longitudinal samples (at least one >3 months after disease onset) and tested them with a live cell-based assay with endpoint titration (1:160 cut-off). Samples were classified as ’attack’ (within 30 days since a disease attack (n=59, 17%)) and ’remission’ (≥31 days after attack (n=295, 83%)).</p> <p><strong>Results . </strong>We included 102 patients with MOGAD (57% adult and 43% paediatric) with a total of 354 samples (83% from remission and 17% from attack). Median titres were higher during attacks (1:1280 vs 1:640, p=0.001). Median onset titres did not correlate with attack-related disability, age or relapses. Remission titres were higher in relapsing patients (p=0.02). When considering the first remission sample available for each patient, titres >1:2560 were predictors of relapsing course in survival (log rank, p<0.001) and multivariate analysis (p<0.001, HR: 10.9, 95% CI 3.4 to 35.2). MOG-IgG seroconversion to negative was associated with a 95% relapse incidence rate reduction (incidence rate ratio: 0.05, p<0.001). Persistent MOG-IgG positivity and high remission titres are associated with an increased relapse risk. Longitudinal MOG-IgG titres could be useful to stratify patients to be treated with long term immunosuppression.</p>
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