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8 results for “Magnetic manipulation”
Magnetic manipulation of intracellular signals
<p>In the context of the MAGNEURON project we have developed magnetic tools to manipulate intracellular proteins involved in intracellular signaling processes. We focused on the manipulation of the subdomain DHPH of ITSN1 in order to control the activity of CDC42.</p> <p>To control the activity of CDC42 we produced a fusion protein consisting in the DHPH domain of ITSN1, the mCherry fluorescent protein and a nanobody against GFP (aGFPnb).</p> <p>The manipulations were done either using a magnetic tip or magnetic micropillars done with soft magnetic material (Nickel Iron alloy). Nanoparticles were first injected in the cytoplasm of the cell. After a delay of at least ten minutes, the survival of the cell was controlled and the manipulation could start.<br> We monitored the fluorescence of the reporter (IRFP-NWASP) and the formation of protrusion/filopodia as markers of a biological response to the manipulation.</p> <p>We observed protrusion formation as well as NWASP activity when attracting the nanoparticles, but control experiments (Manipulation of particles without ITSN1-mcherry-aGFPnb) also showed increase of fluorescence of the NWASP reporter at the point of attraction of the particles.</p> <p>In addition, if compared to optogenetic manipulation of the similar ITSN1-DHPH domain, the formation of protrusion was very limited. We concluded that magnetic manipulation of intracellular signals was not efficient to hijack signaling pathways.</p> <p>We publish here the raw data of some experiments that were produced in the lab.</p> <p>Each experiment has a README file describing the parameter of the recording and what can be observe on the video</p>
Individual skyrmion manipulation by local magnetic field gradients - Dataset
<p>Dataset for the article: Casiraghi A, Corte-León H, Vafaee M, Garcia-Sanchez F, Durin G, Pasquale M, Jakob G, Kläui M and Kazakova O 2019 Individual skyrmion manipulation by local magnetic field gradients 25–7. DOI: 10.1038/s42005-019-0242-5.</p> <p>The data is divided in figures and for each figure we report the raw data and the python code to analyse it.</p>
Telerobotic neurovascular interventions with magnetic manipulation
<p>Advances in robotic technology have been adopted in various subspecialties of both open and minimally invasive surgery, offering benefits such as enhanced surgical precision and accuracy with reduced fatigue of the surgeon. Despite the advantages, robotic applications to endovascular neurosurgery have remained largely unexplored because of technical challenges such as the miniaturization of robotic devices that can reach the complex and tortuous vasculature of the brain. Although some commercial systems enable robotic manipulation of conventional guidewires for coronary and peripheral vascular interventions, they remain unsuited for neurovascular applications because of the considerably smaller and more tortuous anatomy of cerebral arteries. Here, we present a teleoperated robotic neurointerventional platform based on magnetic manipulation. Our system consists of a magnetically controlled guidewire, a robot arm with an actuating magnet to steer the guidewire, a set of motorized linear drives to advance or retract the guidewire and a microcatheter, and a remote-control console to operate the system under real-time fluoroscopy. We demonstrate our system's capability to navigate narrow and winding pathways both in vitro with realistic neurovascular phantoms representing the human anatomy and in vivo in the porcine brachial artery with accentuated tortuosity for preclinical evaluation. We further demonstrate telerobotically assisted therapeutic procedures including coil embolization and clot retrieval thrombectomy for treating cerebral aneurysms and ischemic stroke, respectively. Our system could enable safer and quicker access to hard-to-reach lesions while minimizing the radiation exposure to physicians and open the possibility of remote procedural services to address challenges in current stroke systems of care.</p>
Effects of Osteopathic Manipulative Treatment and Bio Electro-Magnetic Regulation Therapy on Neck Pain in Adults
ClinicalTrials.gov study NCT05889039. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Telerobotic neurovascular interventions with magnetic manipulation
Open the record for dataset details and reuse information.
supplementary video for the manuscript "Parallelized manipulation of adherent living cells by magnetic nanoparticles-mediated forces"
<pre><strong>Video S6: Parallelized magnetic control of Hela cells</strong></pre> <pre><strong>Video S7: Parallelized magnetic control of SHSY-5Y cells</strong></pre> <pre><strong>Video S8: Parallelized magnetic control of cortical neurons</strong></pre> <pre><strong>Video S9: Parallelized magnetic control of cortical neurons</strong></pre> <pre><strong>Video S10&S11: Parallelized magnetic control of PC12 cells</strong></pre> <pre><strong>Video S12: Lysosome labeling of Hela cells</strong></pre> <pre><strong>Video S13: Late endosome labeling of Hela cells</strong></pre>
Research data supporting "Remote magnetic nanoparticle manipulation enables the dynamic patterning of cardiac tissues"
<p>Research data supporting the publication:</p> <p>Zwi-Dantsis et al., 2020, Advanced Materials, DOI: 10.1002/adma.201904598.</p>
Effects of Osteopathic Manipulative Treatment and Bio Electro-Magnetic Regulation Therapy on Low Back Pain in Adults.
ClinicalTrials.gov study NCT04704375. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.