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Dataset results
255 results for “Mast cells”
Efficacy and Safety of Midostaurin in Patients With Aggressive Systemic Mastocytosis or Mast Cell Leukemia
ClinicalTrials.gov study NCT00782067. IPD Sharing: UNDECIDED. Countries: 12. Publications: 3.
Landscape of Mast cell populations across organs in mice and humans
<p><span>Mast cells (MCs) are tissue-resident immune cells which exhibit homeostatic and neuron-associated functions. Here we combined whole-tissue imaging and single-cell RNA sequencing datasets to generate a pan-organ analysis of MCs in mice and humans at steady state. In mice, we identify two mutually exclusive MC populations, MrgprB2<sup>+</sup> connective tissue-type MCs and MrgprB2<sup>neg</sup> mucosal-type MCs, with specific transcriptomic core signatures. While MrgprB2<sup>+</sup> MCs develop<em> in-utero</em> independently of the bone marrow, MrgprB2<sup>neg</sup> MCs develop after birth and are renewed by bone marrow progenitors. In humans, we unbiasedly identify 7 MC subsets (MC1 to 7) distributed across 12 organs with different transcriptomic core signatures. MC1 are preferentially enriched in the bladder, MC2 in the lungs, and MC4, MC6 and MC7 in the skin. Conversely, MC3 and MC5 are shared by most organs, but not skin. This comprehensive analysis offers valuable insights into the natural diversity of MC subtypes in both mice and humans.</span></p>
Phase 2 Midostaurin in Aggressive Systemic Mastocytosis and Mast Cell Leukemia
ClinicalTrials.gov study NCT00233454. IPD Sharing: NO. Countries: 1. Publications: 3.
Mast Cell Activation Test in Allergic Disease
ClinicalTrials.gov study NCT03406325. IPD Sharing: NO. Countries: 1. Publications: 1.
Brentuximab Vedotin in Treating Patients With Advanced Systemic Mastocytosis or Mast Cell Leukemia
ClinicalTrials.gov study NCT01807598. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Analyses Xenopus laevis mast cells, neutrophils, and mast cell-enriched, chytrid infected skin
Open the record for dataset details and reuse information.
Landscape of Mast cell populations across organs in mice and humans
Open the record for dataset details and reuse information.
Study of Mast Cell Precursors
ClinicalTrials.gov study NCT00001756. IPD Sharing: Not stated. Countries: 1. Publications: 5.
MAST - Magnesium for Sickle Cell Acute Crisis in Children
ClinicalTrials.gov study NCT00313963. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clonal Mast Cell Disorders in Exercise-Induced Anaphylaxis
ClinicalTrials.gov study NCT01326741. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Mast Cells in Male Pelvic Pain and and Lower Urinary Tract Dysfunction
ClinicalTrials.gov study NCT03167216. IPD Sharing: NO. Countries: 1. Publications: 3.
Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial
ClinicalTrials.gov study NCT06355583. IPD Sharing: YES. Countries: 1. Publications: 29.
Study of Factors Regulating Mast Cell Proliferation
ClinicalTrials.gov study NCT00044122. IPD Sharing: NO. Countries: 1. Publications: 5.
Masitinib for the Treatment of Severe Mast Cell Activation Syndrome
ClinicalTrials.gov study NCT05449444. IPD Sharing: NO. Countries: 2. Publications: 2.
Crosstalk between Mast Cells and Lung Fibroblasts Is Modified by Alveolar Extracellular Matrix and Influences Epithelial Migration
<p>Datasets for the data generated and presented in the article: https://doi.org/10.3390/ijms22020506</p>
Data from: A synonymous germline variant in a gene encoding a cell adhesion molecule is associated with cutaneous mast cell tumour development in Labrador and Golden Retrievers
Mast cell tumours are the most common type of skin cancer in dogs, representing a significant concern in canine health. The molecular pathogenesis is largely unknown, but breed-predisposition for mast cell tumour development suggests the involvement of inherited genetic risk factors in some breeds. In this study, we aimed to identify germline risk factors associated with the development of mast cell tumours in Labrador Retrievers, a breed with an elevated risk of mast cell tumour development. Using a methodological approach that combined a genome-wide association study, targeted next generation sequencing, and TaqMan genotyping, we identified a synonymous variant in the DSCAM gene on canine chromosome 31 that is associated with mast cell tumours in Labrador Retrievers. DSCAM encodes a cell-adhesion molecule. We showed that the variant has no effect on the DSCAM mRNA level but is associated with a significant reduction in the level of the DSCAM protein, suggesting that the variant affects the dynamics of DSCAM mRNA translation. Furthermore, we showed that the variant is also associated with mast cell tumours in Golden Retrievers, a breed that is closely related to Labrador Retrievers and that also has a predilection for mast cell tumour development. The variant is common in both Labradors and Golden Retrievers and consequently is likely to be a significant genetic contributor to the increased susceptibility of both breeds to develop mast cell tumours. The results presented here not only represent an important contribution to the understanding of mast cell tumour development in dogs, as they highlight the role of cell adhesion in mast cell tumour tumourigenesis, but they also emphasise the potential importance of the effects of synonymous variants in complex diseases such as cancer.
7 Day Study of Mast Cell Inhibitor, R926112, in Patients With Symptomatic Seasonal Allergic Rhinitis
ClinicalTrials.gov study NCT00115089. IPD Sharing: Not stated. Countries: 0. Publications: 1.
A Prospective Clinical Trial Comparing Serum Mast Cell Tryptase (SMCT) Levels to Arthrofibrosis Rates Among Primary Total Knee Arthroplasty (TKA) Patients
ClinicalTrials.gov study NCT03598829. IPD Sharing: NO. Countries: 1. Publications: 0.
A Cohort Study of Correlation Between Mast Cells and Prognosis in Patients With Acute Myocardial Infarction
ClinicalTrials.gov study NCT05802667. IPD Sharing: NO. Countries: 0. Publications: 1.
Characteristics of Mast Cells in Mastocytosis
ClinicalTrials.gov study NCT00001356. IPD Sharing: Not stated. Countries: 1. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.