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7 results for “Maxillofacial Bones”
Maxillofacial bone dataset for the MARGO project
<h2>Bone atlas</h2><p>for the <a href="https://sites.google.com/view/margoflagera/">[MAxillofacial bone Regeneration by 3D-printed laser-activated Graphene Oxide Scaffolds] (MARGO) FLAG–ERA JTC 2019 project.</a></p><p>Dataset includes:</p><ul><li>Info.xlsx: Datasheet with info for each subject.</li><li>Thumbnails.zip: Thumbnails of the CT and CBCT images.<br>240 image files in .png format, 826x736 pixels, of each dataset, rendered using a volume rendering transfer function.</li><li>M_mandible.zip: Segmented mesh surfaces of the mandible (.ply files). Currently 115 files are included (see Info.xlsx).</li><li>MargoTemplate.zip: Template of landmarks. This file is compatible with the <a href="https://www.dhal.com">Viewbox software (www.dhal.com)</a>.</li><li>Margo100_GM_slide.xml: The landmark coordinates of 100 mesh surfaces. This file is compatible with the <a href="https://www.dhal.com">Viewbox software (www.dhal.com)</a>.</li></ul><p>Please note: previous versions contained some duplicates; these have been removed.</p><p>Please contact <a href="mailto:dhal@dhal.com">dhal@dhal.com</a> for information about the Template and landmark coordinates files.</p>
Quantitative results of the analysis of two types of bone particles corresponding to the work "A comprehensive analysis of two types of xenogeneic bone particles for use in maxillofacial bone regeneration therapies"
<p>This dataset corresponds to the quantitative data generated in the work entitled "A comprehensive analysis of two types of xenogeneic bone particles for use in maxillofacial bone regeneration therapies".</p> <p>Regeneration of maxillofacial bone structures is challenging. One of the strategies applied to bone damage repair is the use of bone filler particles, and different types of these particles have been tested. In this work, we analyzed the regenerative potential of deproteinized bone particles (DP) and collagen-based bone particles (CP) to determine the potential of each biomaterial in bone repair. Results of the structural analysis using scanning electron microscopy and 3D scanning showed that DP and CP were structurally similar, and consisted of a heterogeneous mixture of bone particles of different sizes and shapes. Then, ex vivo analyses using morphological evaluation, LIVE & DEAD and quantification of DNA released to the medium demonstrated that CP and DP were highly biocompatible when used in direct and in indirect contact with human cells, at 24, 48 and 72h of follow-up. Then, when both particles were grafted for 2 months on Wistar rats in which a critical defect had been generated at the mandible bone. Results of the computed tomography analysis showed a significant reduction of the bone defect in the CP group, but not in the DP group, as compared with negative controls devoid of any bone particles. Histological analysis of the graft area revealed that both particles were biocompatible in vivo, and a regenerative tissue with collagen fibers and mineralized spots was found in CP and DP, with higher number of mineralized spots in DP. Histochemistry and immunohistochemistry analyses confirmed the presence of collagen, proteoglycans and osteocalcin at the regeneration area of CP and DP. In general, these results confirm the biocompatibility of both types of particles and that both were able to induce maxillofacial bone regeneration, especially in the case of CP. Future studies should determine their clinical usefulness in patients with cleft palate, mandibular damage and other maxillofacial applications.</p>
Gene-activated Matrix for Bone Tissue Repair in Maxillofacial Surgery
ClinicalTrials.gov study NCT02293031. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Gene-activated Bone Substitute for Maxillofacial Bone Regeneration
ClinicalTrials.gov study NCT03076138. IPD Sharing: YES. Countries: 1. Publications: 5.
Filling Bone Defects/Voids With Autologous BonoFill For Maxillofacial Bone Regeneration
ClinicalTrials.gov study NCT02153268. IPD Sharing: NO. Countries: 1. Publications: 0.
Filling Bone Defects/Voids With Autologous BonoFill-II for Maxillofacial Bone Regeneration
ClinicalTrials.gov study NCT02842619. IPD Sharing: NO. Countries: 1. Publications: 0.
The Clinical and Radiographic Outcomes of a 3D-printed Patient-specific Biomimetic Bone Substitute in Maxillofacial Indications: an Interventional, Multi-centred, Open-label, Post-market Clinical Inve
ClinicalTrials.gov study NCT04773847. IPD Sharing: YES. Countries: 0. Publications: 0.
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