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9 results for “Mechanosensitive ion channels”
Data from: Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels
<p><span>The transmission of heartbeat through the cerebral vascular system is known to cause intracranial pressure pulsations. Here we report that arterial pressure pulsations can directly modulate central neuronal activity. </span><span>In a semi-intact rat brain preparation, vascular pressure pulsations elicit correlated local field oscillations in the olfactory bulb (OB) mitral cell layer. These oscillations do not require synaptic transmission, but reflect baroreceptive transduction in mitral cells. This transduction is mediated by an excitatory mechanosensitive ion channel and modulates neuronal spiking activity. Indeed, in awake animals, the heartbeat entrains the activity of a subset of OB neurons within ~20 ms. Thus, we propose that this fast intrinsic interoceptive mechanism can modulate perception, e.g. during arousal, within the OB and also possibly across various brain areas.</span></p>
Data from: Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels
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Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion channel PIEZO1 as cardioprotective [snMultiome]
GEO Series GSE309754. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion channel PIEZO1 as cardioprotective
GEO Series GSE309753. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation [scRNA-seq]
GEO Series GSE286425. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion channel PIEZO1 as cardioprotective [bulk RNA-seq]
GEO Series GSE309795. Homo sapiens. 72 samples. Type: Expression profiling by high throughput sequencing.
The chondrocyte “mechanome”: Activation of the mechanosensitive ion channels TRPV4 and PIEZO1 drives unique transcriptional signatures
GEO Series GSE269159. Sus scrofa. 120 samples. Type: Expression profiling by high throughput sequencing.
Mechanosensitive ion channel regulates tissue stiffening to promote glioma aggression
GEO Series GSE113261. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation [bulk RNA-seq]
GEO Series GSE286424. Mus musculus. 46 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.