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828 results for “Menopause”
The Relationship between LRP5 (rs556442 and rs638051) Polymorphisms and Mutation with Bone Metabolism in Xinjiang women with Type 2 Diabetes after Menopause(Table 1 and Table 2 Statistical Values of Analysis Process)
<p>The Relationship between LRP5 (rs556442 and rs638051) Polymorphisms and Mutation with Bone Metabolism in Xinjiang women with Type 2 Diabetes after Menopause(Table 1 and Table 2 Statistical Values of Analysis Process)</p>
Phase 2 Window Study of SAR439859 (Amcenestrant) Versus Letrozole in Post-menopausal Patients With ER+, HER2- Pre-operative Post-menopausal Primary Breast Cancer
ClinicalTrials.gov study NCT04191382. IPD Sharing: YES. Countries: 9. Publications: 1.
Data from: Current ecology, not ancestral dispersal patterns, influences menopause symptom severity
<p>All human females who reach midlife experience menopause, however, it is currently unclear why women experience this period of infertility, and why it is accompanied by many unpleasant symptoms. Using primary data from four ethnic groups in China, we test an existing theory that age of menopause and its symptoms are the result of intragenomic conflict between maternally and paternally inherited genes, with the outcome of such conflict predicted to be contingent on the ancestral post-marital residence pattern of the female (Úbeda et al., 2014). The model predicts that being ancestrally patrilocal results in less intragenomic conflict, causing a shorter, less symptomatic peri-menopause that terminates in a later menopause. Our findings show no support for this hypothesis, and suggest current, rather than ancestral, residence patterns better predict aspects of the menopausal transition. Furthermore, current patrilocality when compared to duolocality is associated with more severe menopause symptoms, which may be due to sexual, rather than intragenomic, conflict.</p>
Assessment of cardiovascular risk in post-menopausal women in Ghana
<p><strong>Background</strong>: Cardiovascular diseases (CVD) continue to be major cause of death among post-menopausal women. <strong>Aim:</strong> we sought to assess cardiovascular risk among pre and post-menopausal women living within the Cape Coast Municipality, by comparing the lipid profiles and other emerging biomarkers of CVD i.e. atherogenic index of plasma (AIP), visceral adiposity index (VIA), body adiposity index (BAI) and Castelli index I (CRI-I).</p> <p><strong>Method:</strong> A cross section of 150 women (75 pre-menopausal women and 75 post-menopausal women) were randomly recruited into the study. Socio-demographic and clinical characteristics of participants were obtained with the aid of a structured questionnaire. Blood pressure (BP) was measured and Lipid profile was estimated using fasting blood samples. Other markers of cardiovascular risk such as BMI, AIP, VAI, BAI and CRI-I were estimated.</p> <p><strong>Results: </strong>We report elevated levels of total cholesterol (TC) (p<0.0001), low density lipoprotein (LDL) (p<0.0001), very low-density lipoprotein (VLDL)(p=<strong>0.0021)</strong>, Triglycerides (TG) (p<0.0001) and non-high-density lipoprotein (non-HDL-C) cholesterol (p<0.0001) in post-menopausal women in contrast to pre-menopausal women. High-density lipoprotein (HDL) (p<0.0001) was however decreased in post-menopausal women. Mean AIP (p<strong>< 0.0001)</strong>, VAI (p<strong>< 0.0001)</strong>, BAI (p<<strong> 0.0038)</strong> and CRI-I (p<<strong>0.0001)</strong> were significantly increased in post-menopausal women compared to pre-menopausal women. We also report a positive correlation of TC, TG, VLDL and NON-HDL with atherogenic markers AIP, VAI and CRI-I in post-menopausal women. A negative correlation of HDL with AIP, VAI, and CR in post-menopausal women was also observed.</p> <p><strong>Conclusion:</strong> Menopause could lead to changes in lipid profile to atherogenicity with associated increase in the risk of CVD. Atherogenic markers such as AIP, VAI, BAI, and CR can serve as potential biomarkers for predicting CVD.</p>
A INTERVENTIONAL CROSS SECTIONAL STUDY BETWEEN INTRA VAGINAL PLATELET RICH PLASMA AND ESTROGEN FOR TREATMENT OF GENITO-URINARY SYNDROME IN POST MENOPAUSAL WOMEN.
<p>Genitourinary syndrome of menopause (GSM) is a new term for a condition more renowned as atrophic vaginitis. It is used to describe a variety of menopausal symptoms and signs that are related to the physical changes of the vulva, vagina and lower urinary tract. The etiology of GSM is secondary to decreased levels of endogenous estrogens and represents a common but underreported condition. Currently Intra-Vaginal application of oestrogen has been considered an effective treatment of atrophic vaginitis.Recently, PRP has becoming popular as a non-operative treatment option for GSM symptoms.Our study focuses on the use platelet rich plasma for the treatment of GSM as it has natural mechanisms of cell regeneration and requires less frequent dosing and have better compliance when compared to estrogen creams. Purpose of the study is to compare the effectiveness of intra vaginal estrogen cream with intravaginal PRP in treatment of GSM.</p>
A 6-month Observational Study on Combined Oral Contraceptives and Body Weight in Pre-Menopausal Women With Overweight or Obesity
ClinicalTrials.gov study NCT05061472. IPD Sharing: UNDECIDED. Countries: 1. Publications: 16.
Safety and Pharmacokinetics of Dapivirine Vaginal Ring in Post-menopausal Women
ClinicalTrials.gov study NCT02010593. IPD Sharing: NO. Countries: 1. Publications: 2.
The Menopause Transition: Estrogen Variability, Stress Reactivity and Mood
ClinicalTrials.gov study NCT03003949. IPD Sharing: YES. Countries: 1. Publications: 1.
DIVA Study - A Study of Different Regimens of Intravenous Administration of Bonviva (Ibandronate) in Women With Post-Menopausal Osteoporosis
ClinicalTrials.gov study NCT00048074. IPD Sharing: Not stated. Countries: 16. Publications: 1.
Anti-tumour Effects & Tolerability of Faslodex Alone or in Combination With Arimidex in Post Menopausal Women Prior to Surgery for Primary Breast Cancer
ClinicalTrials.gov study NCT00259090. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Fulvestrant +/- Everolimus in Post-Menopausal, Hormone-Receptor + Metastatic Breast Ca Resistant to AI
ClinicalTrials.gov study NCT01797120. IPD Sharing: NO. Countries: 1. Publications: 1.
Mindfulness-Based Self-Compassion Training for Menopausal Women
ClinicalTrials.gov study NCT06942169. IPD Sharing: YES. Countries: 1. Publications: 6.
Study Evaluating The Safety And Efficacy Of Desvenlafaxine Succinate For Vasomotor Symptoms In Menopausal Women
ClinicalTrials.gov study NCT00683800. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Safety and Efficacy of Telapristone Acetate (Proellex®) in the Treatment of Pre-Menopausal Women With Confirmed, Symptomatic Endometriosis
ClinicalTrials.gov study NCT01728454. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neuropeptide Treatment for Hot Flushes During the Menopause
ClinicalTrials.gov study NCT02668185. IPD Sharing: NO. Countries: 1. Publications: 3.
A Study to Find Out if Fezolinetant Helps Reduce Moderate to Severe Hot Flashes in Women Going Through Menopause - 2
ClinicalTrials.gov study NCT04003142. IPD Sharing: YES. Countries: 7. Publications: 6.
Vortioxetine for Menopausal Depression
ClinicalTrials.gov study NCT02234362. IPD Sharing: NO. Countries: 1. Publications: 5.
Attention & Memory Impairments in Menopausal Women
ClinicalTrials.gov study NCT01324024. IPD Sharing: NO. Countries: 1. Publications: 2.
Open-Label Drug Interaction Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) 100mg On The Pharmacokinetics Of Tamoxifen When Coadministered To Healthy Post-Menopausal Female Subjec
ClinicalTrials.gov study NCT01189500. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Time-Restricted Eating in Combination With a Low Glycaemic Index Diet on Cognitive Function, Biological Ageing and Metabolic Health in Perimenopause and Menopause.
ClinicalTrials.gov study NCT07378787. IPD Sharing: YES. Countries: 2. Publications: 1.
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OpenNeuro
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