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331 results for “Metabolic impacts”
Dataset: Bacterioplankton metabolism of phytoplankton lysates across a cyclone-anticyclone eddy dipole impacts the cycling of semi-labile organic matter in the photic zone
<p>This dataset contains both field data and the results of dilution batch-culture bioassay experiments characterizing bacterioplankton usage of ambient and added dissolved organic matter across a cyclone to anticyclone spatial transect in the North Pacific Subtropical Gyre. Field data include total organic carbon, total nitrogen, bacterioplankton cell abundances, ammonia monooxygenase subunit A gene concentrations, and 16S rRNA gene amplicons. Experimental data include time-resolved changes in total organic carbon, nitrogen species, and bacterioplankton cell abundances.</p>
Larval nutrition impacts survival to adulthood, body size, and the allometric scaling of metabolic rate in adult honeybees
<p>Resting metabolic rate (RMR) is a fundamental physiological measure linked to numerous aspects of organismal function, including lifespan. Although dietary restriction in insects during larval growth/development affects adult RMR, the impact of larval diet <i>quality</i> on adult RMR has not been studied. Using <i>in vitro</i> rearing to control larval diet quality, we determined the effect of dietary protein and carbohydrate on honeybee survival-to-adulthood, time-to-eclosion, body mass/size and adult RMR. High carbohydrate larval diets increased survival-to-adulthood and time-to-eclosion compared to both low carbohydrate and high protein diets. Upon emergence, bees reared on the high protein diet were smaller and lighter than those reared on other diets, whilst those raised on the high carbohydrate diet varied more in body mass. Newly emerged adult bees' reared on the high carbohydrate diet showed a significantly steeper increase in allometric scaling of RMR compared to those reared on other diets. This suggests that diet quality influences survival-to-adulthood, time-to-eclosion, and the allometric scaling of RMR. Given that agricultural intensification and increasing urbanisation have led to a decrease in both forage availability and dietary diversity for bees, our results are critical to improving understanding of the impacts of poor developmental nutrition on bee growth/development and physiology.</p>
In Vitro Fertilization Impact on Metabolic Parameters
ClinicalTrials.gov study NCT03426228. IPD Sharing: YES. Countries: 1. Publications: 2.
Larval nutrition impacts survival to adulthood, body size, and the allometric scaling of metabolic rate in adult honeybees
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The impact of metabolic plasticity on winter energy use models
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Differential impacts of calcium and aluminum treatments on foliar and sapwood nutrition and metabolism of sugar maple trees growing at the west edge of WS6 of the Hubbard Brook Experimental Forest from 1997-2009.
Plot levels Ca and Al additions study at WS6 BACKGROUD: To better evaluate the interaction of Ca depletion and Al mobilization on a northern hardwood forest, the Nutrient Perturbation (NuPert) study was initiated in 1995, west of the biogeochemical reference watershed (W6) at the HBEF (43.95411°N, 71.74779°W). The study area is on a south-facing slope, with an elevational range of 700–760 m, and most soils are classified as either Aquic Haplorthods or Aquic Haplumbredts (Halman et al. 22015 and references therein). Twelve sugar maple (Acer saccharum Marshall) dominated plots (45 m × 45 m) were randomly assigned to one of three treatments (Ca addition, Al addition, or control (no addition)), yielding four replicates of each treatment in the study. In addition to sugar maple, American beech (Fagus grandifolia Ehrh.) and yellow birch (Betula alleghaniensis Britt.) are co-occurring tree species in these plots, whereas hobblebush (Viburnum lantanoides Michx.) and striped maple (Acer pensylvanicum L.) dominate the understory. Treatments began in 1995 with annual CaCl2 (2.5 g·m−2) and AlCl3 (0.9 g·m−2) applications occurring each fall or spring during leafless periods. The use of CaCl2 was halted in 1999 in favor of a one-time application (38 g·m−2) of wollastonite (CaSiO3, a slow-release form of Ca). Thereafter, AlCl3 additions occurred in alternate years in fall or spring. Foliage was collected from sunlit branches in the upper to mid canopy dominant sugar maple trees. Five trees per plot of each group were selected for sampling in August 2008. There was an ice storm in 1998 at this site which might have interfered with this study findings. In 2009, tiny sapwood plugs were also collected. All the analyses were carried out using the procedures described under section A (Ca-supplementation study). SUMMARY: Acid deposition induced losses of calcium (Ca) from northeastern forests have had negative effects on forest health for decades, including the mobilization of potentiall
Data from: Gut microbiome critically impacts PCB-induced changes in metabolic fingerprints and the hepatic transcriptome in mice
<p class="western"><span><span><span>Polychlorinated biphenyls (PCBs) are ubiquitously detected in the environment and have been linked to metabolic diseases. The liver serves as a central hub for the metabolism of xenobiotics and endogenous metabolites. Gut dysbiosis is recognized as a critical regulator of disease susceptibility, however, little is known regarding how PCBs and gut microbiome interact to modulate the interface between xenobiotic and intermediary metabolism. We hypothesized that the gut microbiome regulates PCBs-mediated changes in the metabolic fingerprints and hepatic transcriptome. Ninety-day-old female conventional (CV) and germ-free (GF) C57BL/6 mice were orally exposed to the PCB Fox River Mixture (synthetic PCB mixture, 6 or 30 mg/kg) or corn oil (vehicle control, 10 ml/kg), once daily for 3 consecutive days. Organs were collected 24 hours after the final dose. RNA-Seq was conducted on liver, and endogenous aqueous metabolites (amino acids, carbohydrates, and nucleotides) were measured in liver and serum by LC-MS. The primary factor in clustering the transcriptomic and metabolomic signatures within the same exposure was by enterotype. The numbers of PCB-regulated genes were higher in CV than in GF conditions. The prototypical target genes of the major xenobiotic-sensing transcription factors AhR, PXR, and CAR were more readily up-regulated by PCBs in CV than in GF conditions, indicating the effect of PCBs on the hepatic transcriptome act partly through the gut microbiome. Xenobiotic and steroid metabolism pathways were up-regulated, whereas response to incorrect proteins pathway was down-regulated by PCBs in a gut microbiome-dependent manner. At the high PCB dose, NADP and arginine appear to interact with drug-metabolizing enzymes (Cyp1-3 family, DhcR7, and Nqo1), which are highly correlated with <i>Anaerotruncus</i> and <i>Roseburia</i> in CV mice, providing a novel explanation of gut-liver interaction in toxicant exposures. In GF exposure groups, hepatic glucose was down-regulated, whereas fructose 6-phosphate and glucose 6-phosphate were up-regulated, indicating increased glucose utilization potentiated by lack of gut microbiota. Through querying the LINCS L1000 chemical database, Enrichr predicted that therapeutic drugs targeting the anti-inflammatory and ER stress pathways are potential remedies to mitigate PCB toxicity. In conclusion, our findings demonstrate that habitation of the gut microbiota drives PCBs-mediated hepatic responses, possibly due to crosstalk between gut and liver. </span></span></span></p>
Larval nutrition impacts the scaling of adult metabolic rate with body mass in honeybees
<p>Resting metabolic rate (RMR) is a fundamental physiological measure linked to numerous aspects of organismal function, including lifespan. Although dietary restriction in insects during larval growth/development affects adult RMR, the impact of larval diet quality on adult RMR has not been studied. Using in vitro rearing to control larval diet quality, we determined the effect of dietary protein and carbohydrate on honeybee survival-to-adulthood, time-to-eclosion, body mass/size and adult RMR. High carbohydrate larval diets increased survival-to-adulthood and time-to-eclosion compared to both low carbohydrate and high protein diets. Upon emergence, bees reared on the high protein diet were smaller and lighter than those reared on other diets, whilst those raised on the high carbohydrate diet varied more in body mass. Newly-emerged adult bees' reared on the high carbohydrate diet showed a significantly steeper increase in allometric scaling of RMR compared to those reared on other diets. This suggests that diet quality influences survival-to-adulthood, time-to-eclosion, and the allometric scaling of RMR. Given that agricultural intensification and increasing urbanisation have led to a decrease in both forage availability and dietary diversity for bees, our results are critical to improving understanding of the impacts of poor developmental nutrition on bee growth/development and physiology.</p>
Metabolic impacts of climate change on marine fish communities and fisheries - Dataset and figure plot script
<p>Here we provide the MATLAB functions, model forcing data (net primary production and temperature), and model output required to generate the figures and perform calculations from the manuscript "Metabolic impacts of climate change on marine fish communities and fisheries", which is currently in submission as a research article. The figures plot script (plot_figures_climate_fish_deconstruction.m) is written in MATLAB version R2012a.</p>
Data from: anterior pituitary transcriptomics following a high fat diet: impact of oxidative stress on cell metabolism
<p>Anterior pituitary cells are highly active with regards to protein synthesis and secretion, processes which depend heavily on mitochondrial ATP production and functional endoplasmic reticula. It is well known that obesity adds an allostatic overload to tissues, requiring them to adapt to inflammation and oxidative stress. Therefore, we hypothesized that the pituitary is highly vulnerable to the stress of high fat diet-induced weight gain. In this study, we utilized a 10-15 week high fat diet (HFD, 60%) plus a thermoneutral housing paradigm, testing both male and female FVB.129P mice. We quantified serum hormones and cytokines, characterized the metabolic phenotype, and defined changes in the pituitary transcriptome using single-cell RNA-seq. Weight gain was significant by 3 weeks in HFD mice, and by 10 weeks all HFD groups had gained 20 g. HFD females (15 weeks) had increased energy expenditure and decreased activity. All HFD groups showed increases in serum leptin, Il-6, resistin, MCP-1, and TNFα. HFD males had increased insulin; both HFD males and females had increased TSH, and HFD females had decreased serum prolactin and growth hormone (GH) pulse amplitude. Pituitary scRNA-seq revealed modest or no changes in pituitary cell gene expression in the different cell types from HFD males after 10 or 15 weeks or HFD females after 10 weeks. However, females exposed to a HFD for 15 weeks showed significant numbers of differentially expressed genes in lactotropes and stem cells. Pathway analyses identified a reduction in pathways that supported protein translation, ribosome biogenesis, and oxidative phosphorylation, indicating mitochondrial dysfunction. Collectively, these studies reveal that pituitary cells from males are more resilient to the oxidative stress of obesity than females and identify the most vulnerable pituitary cell populations in females.</p>
Impacts of male-killing Spiroplasma on the metabolic rate and ectoparasite resistance capacity (endurance) of Drosophila
<p>Ectoparasitic mites are hypothesized to horizontally transmit bacterial endosymbionts, especially male-killing Spiroplasma. In this study we test how <em>Spiroplasma poulsonii </em>MSRO affects fly physiology and behaviour, and potential mite interactions.</p>
Data from: Mitonuclear interactions impact aerobic metabolism in hybrids and may explain mitonuclear discordance in young, naturally hybridizing bird lineages
<p>Understanding genetic incompatibilities and genetic introgression between incipient species are major goals in evolutionary biology. Mitochondrial genes evolve rapidly and exist in dense gene networks with coevolved nuclear genes, suggesting that mitochondrial respiration may be particularly susceptible to disruption in hybrid organisms. Mitonuclear interactions have been demonstrated to contribute to hybrid dysfunction between deeply divergent taxa crossed in the laboratory, but there are few empirical examples of mitonuclear interactions between younger lineages that naturally hybridise. Here we use controlled hybrid crosses and high resolution respirometry to provide the first experimental evidence in a bird that inter-lineage mitonuclear interactions impact mitochondrial aerobic metabolism. Specifically, respiration capacity of the two mitodiscordant backcrosses (with mismatched mito-nuclear combinations) differ from one another, although they do not differ significantly from the parental groups or mitoconcordant backcrosses as we would expect of mitonuclear disruptions. In the wild hybrid zone between these subspecies the mitochondrial cline centre is shifted west of the nuclear cline centre, which is consistent with the direction of our experimental results. Our results therefore demonstrate asymmetric mitonuclear interactions that impact the capacity of cellular mitochondrial respiration and may help to explain the geographic discordance between mitochondrial and nuclear genomes observed in the wild.</p>
Data for Marshall et al, "Microbial metabolism disrupts cytokine activity to impact host immune response"
<p>Raw data for publication "Microbial metabolism disrupts cytokine activity to impact host immune response", Marshall EKP et al. The archive is organized into folders containing raw data pertaining to each figure.</p>
Impacts of neonicotinoid insecticides on bumble bee energy metabolism are revealed under nectar starvation
<p>Bumble bees are an important group of insects that provide essential pollination services as a byproduct of their foraging behaviors. These pollination services are driven, in part, by energetic exchanges between flowering plants and individual bees. Thus, it is important to examine bumble bee energy metabolism and explore how it might be influenced by external stressors, which contribute to declines in global pollinator populations. Two stressors that are commonly encountered by bees include insecticides and nutritional stress. Our study examines the effects of neonicotinoid insecticide exposure alone, and in combination with nutritional stress, on bumble bee metabolism using a novel metabolomic approach. We hypothesized that exposure to the insecticide imidacloprid would disrupt bumble bee energy metabolism, leading to changes in key metabolites involved in energy metabolism. We exposed Bombus impatiens workers to imidacloprid according to one of three exposure paradigms designed to explore how sustained versus more limited imidacloprid exposure influences energy metabolites. After bees were exposed to imidacloprid, they were subjected to artificial nectar starvation. Our results showed that the strongest effects of imidacloprid were observed when treated bees also experienced artificial nectar starvation, suggesting a combinatorial effect of neonicotinoids and nutritional stress on energy metabolism. Overall, this study provides important insights into the mechanisms underlying the impact of neonicotinoid insecticides on bumble bees and underscores the need for further investigation into the complex interactions between environmental stressors and bee metabolism.</p>
Impact of prolonged chronic social isolation stress on behavior and multifractal complexity of metabolic rate in Octodon degus
<p>We investigated the effects of prolonged chronic social isolation stress on behavioral, cognitive, and physiological performance in the social, long-lived rodent <em>Octodon degus</em>. Degu pups were separated into two social stress treatments: control (CTRL) and chronically isolated (CI) individuals from post-natal and post-weaning until adulthood. We quantified anxiety-like behavior and cognitive performance with behavioral tests. Additionally, we measured their basal metabolic rate (BMR). Data include behavioral tests and physiological traits (body mass and Basal Metabolic Rate).</p>
The Impact of Free Fatty Acid Reduction on Vascular Function in the Metabolic Syndrome
ClinicalTrials.gov study NCT00759291. IPD Sharing: NO. Countries: 1. Publications: 2.
The Impact of Intermittent Fasting on Human Metabolism and Cell Autophagy
ClinicalTrials.gov study NCT02673515. IPD Sharing: NO. Countries: 1. Publications: 3.
Immunosuppression Impact on the Metabolic Control of Kidney Transplant With Pre-Existing Type 2 Diabetes (DM)
ClinicalTrials.gov study NCT00296296. IPD Sharing: NO. Countries: 1. Publications: 8.
Impact of Healthy Diet on Metabolic Health in Men and Women
ClinicalTrials.gov study NCT04062682. IPD Sharing: YES. Countries: 1. Publications: 1.
Impact of Antiretroviral Therapy on Metabolic, Skeletal, and Cardiovascular Parameters
ClinicalTrials.gov study NCT00851799. IPD Sharing: Not stated. Countries: 1. Publications: 11.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.