Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
600
datasets available to search
ShareScore release 0.9.0
Dataset results
600 results for “Mucosa”
Extensive qPCR analysis reveals altered gene expression in middle ear mucosa from cholesteatoma patients
<p><strong>Abstract</strong></p> <p>The middle ear is a small and hard to reach compartment, limiting the amount of tissue that can be extracted and the possibilities for studying the molecular mechanisms behind diseases like cholesteatoma. In this paper 14 reference gene candidates were evaluated in the middle ear mucosa of cholesteatoma patients and two different control tissues. <em>ACTB</em> and <em>GAPDH</em> were shown to be the optimal genes for the normalisation of target gene expression when investigating middle ear mucosa in multiplex qPCR analysis. Validation of reference genes using <em>c-MYC</em> expression confirmed the suitability of <em>ACTB</em> and <em>GAPDH</em> as reference genes and showed an upregulation of <em>c-MYC</em> in middle ear mucosa during cholesteatoma. The occurrence of participants of the innate immunity, <em>TLR2</em> and <em>TLR4</em>, were analysed in order to compare healthy middle ear mucosa to cholesteatoma. Analysis of <em>TLR2</em> and <em>TLR4</em> showed variable results depending on control tissue used, highlighting the importance of selecting relevant control tissue when investigating causes for disease. It is our belief that a consensus regarding reference genes and control tissue will contribute to the comparability and reproducibility of studies within the field.</p>
Full summary statistics of mixQTL for GTEx v8 Esophagus_Mucosa
The mixQTL method is described in paper doi.org/10.1101/2020.04.22.050666. Please cite the original paper if using the data.
Fig 4 in Campylobacter portucalensis sp. nov., a new species of Campylobacter isolated from the preputial mucosa of bulls
Fig 4. Subsystem category distribution in the genome of isolate FMV-PI01, based on the RAST server. https://doi.org/10.1371/journal.pone.0227500.g004
Fig 3 in Campylobacter portucalensis sp. nov., a new species of Campylobacter isolated from the preputial mucosa of bulls
Fig 3. Phylogenetic tree based on hsp60 gene sequences of Campylobacter species, reconstructed by the neighbourjoining method. Bootstrap values (%) obtained from 1000 simulations are indicated at the nodes. Bootstrap values lower than 70% are not shown. Bar: 0.050 substitutions per site. https://doi.org/10.1371/journal.pone.0227500.g003
Fig 1 in Campylobacter portucalensis sp. nov., a new species of Campylobacter isolated from the preputial mucosa of bulls
Fig 1. Electron micrographs of isolate FMV-PI01. (A) Transmission electron microscope micrograph in longitudinal and transverse views. Scale bar, 500 nm. (B) Scanning electron microscope micrograph in detail. Scale bar, 2 μm (C) Scanning electron microscope micrograph with evident long filamentous cells (white arrow). Scale bar, 2 μm.
Fig 2 in Campylobacter portucalensis sp. nov., a new species of Campylobacter isolated from the preputial mucosa of bulls
Fig 2. Phylogenetic tree based on 16S rRNA gene sequences of Campylobacter species, reconstructed by the neighbour-joining method. Bootstrap values (%) obtained from 1000 simulations are indicated at the nodes. Bootstrap values lower than 70% are not shown. Bar: 0.0050 substitutions per site. https://doi.org/10.1371/journal.pone.0227500.g002
dataset related to article: "PMCA-Based Detection of Prions in the Olfactory Mucosa of Patients With Sporadic Creutzfeldt-Jakob Disease"
<ol> <li>ESTIMATING PRION CONCENTRATION IN THE OM OF SCJD MM1, MV2 AND VV2 PATIENTS BY MEANS OF QUANTITATIVE PMCA (QPMCA)</li> <li>EVALUATION OF THE BIOCHEMICAL PROPERTIES OF PMCA GENERATED PRODUCTS</li> <li>PMCA ANALYSIS OF SCJD BRAIN HOMOGENATES</li> <li>PMCA ANALYSIS OF SCJD OLFACTORY MUCOSA</li> <li>RT-QuIC ANALYSIS OF OM AND BH OF SCJD PATIENTS AND CONTROLS</li> <li>WESTERN BLOT ANALYSIS OF BRAIN HOMOGENATES</li> <li>STATISTICAL ANALYSIS</li> </ol>
Rollinia cf. mucosa (Jacq.) Baill. from Colombia collected by F. Moreno y C. Carvajal #2715
<p><strong>File Name</strong>: <span>TOLI-25319-PER-01-L4-5.jpg</span></p> <p><strong>CÓDIGO FOTO</strong>: <span>TOLI-25319-PER-01-L4-5-</span></p> <p><strong>Fotografía</strong>: <span>SI</span></p> <p><strong>Nº TOLI</strong>: <span>TOLI-25319</span></p> <p><strong>PARCELA</strong>: <span>PER-01</span></p> <p><strong>CÓDIGO</strong>: <span>L4-5</span></p> <p><strong>Nº COLECTA</strong>: <span>2715</span></p> <p><strong>NUEVOS COLECTORES</strong>: <span>Esteban Álvarez Dávila</span></p> <p><strong>COLECTORES</strong>: <span>F. Moreno y C. Carvajal</span></p> <p><strong>Nº MUESTRAS MONTADAS</strong>: <span>1</span></p> <p><strong>Homologación</strong>: <span>Homologado</span></p> <p><strong>Nueva fecha del evento </strong>: <span>20/12/2018.</span></p> <p><strong>Fecha del evento</strong>: <span>01/09/2012.</span></p> <p><strong>Proyecto </strong>: <span>Recursos Botánicos Disponibles en Línea (BRAVO) para la flora Colombiana</span></p> <p><strong>Hábitat</strong>: <span>Bosque húmedo tropical (bh-T)</span></p> <p><strong>Comentario del evento</strong>: <span>Bosque de tierra firme, dosel abierto, de 25-30 m, emergentes de 35 m, estrato medio de 15 m, sotobosque denso con alta regeneración natural, presencia de palmas como Lepidocaryum tenue, Oenocarpus bataua, Geonoma sp., capa de hojarazca de 15 cm, abundante materia orgánica. Pendientes pronunciadas. Poca intervención antrópica.</span></p> <p><strong>Continente</strong>: <span>SA</span></p> <p><strong>Pais</strong>: <span>Colombia</span></p> <p><strong>Estado/Provincia</strong>: <span>Amazonas</span></p> <p><strong>Municipio</strong>: <span>Puerto Santander</span></p> <p><strong>Localidad</strong>: <span>Resguardo indígena Nonuya de Villazul.</span></p> <p><strong>Elevación minima en metros</strong>: <span>250</span></p> <p><strong>Elevación maxima en metros</strong>: <span>400</span></p> <p><strong>Latitud</strong>: <span>-0.654</span></p> <p><strong>Longitud original</strong>: <span>-72.072</span></p> <p><strong>datum geodésico</strong>: <span>WGS 84</span></p> <p><strong>Latitud decimal</strong>: <span>-0.654</span></p> <p><strong>Longitud decimal</strong>: <span>-72.072</span></p> <p><strong>Identificado por</strong>: <span>Jaime Cabezas</span></p> <p><strong>Fecha de identificación</strong>: <span>23/04/2019.</span></p> <p><strong>Familia antigua</strong>: <span>Annonaceae</span></p> <p><strong>Especie antigua</strong>: <span>NN</span></p> <p><strong>Nombre cientifico</strong>: <span>Rollinia cf. mucosa (Jacq.) Baill.</span></p> <p><strong>Reino</strong>: <span>Plantae</span></p> <p><strong>Filo</strong>: <span>Magnoliophyta</span></p> <p><strong>Clase</strong>: <span>Equisetopsida</span></p> <p><strong>Orden</strong>: <span>Magnoliales</span></p> <p><strong>Familia nueva</strong>: <span>Annonaceae</span></p> <p><strong>Género nuevo</strong>: <span>Rollinia </span></p> <p><strong>especie nueva</strong>: <span>cf. mucosa </span></p> <p><strong>Autoría del nombre científico</strong>: <span>(Jacq.) Baill.</span></p> <p><strong></strong>: <span>Annonaceae</span></p> <p><strong>genero herbario</strong>: <span>Rollinia</span></p> <p><strong>especie herbario</strong>: <span>mucosa</span></p> <p><strong>Especie de herbario para TNRS</strong>: <span>Rollinia mucosa</span></p> <p><strong>Especie corregida herbario y desde TNRS</strong>: <span>Rollinia mucosa</span></p> <p><strong>Familia corregida desde TNRS</strong>: <span>Annonaceae</span></p> <p><strong></strong>: <span>4330</span></p>
Tissue-resident memory Th17 cells maintain stable fungal commensalism in the oral mucosa
<p>Raw data files linked to a manuscript published in Mucosal Immunology 2020 (accepted for publication on July 6th,.2020)</p>
Dendritic cell subsets in oral mucosa of allergic and healthy subjects
<p><strong>Abstract</strong></p> <p>Immunohistochemistry was used to identify, enumerate, and describe the tissue distribution of Langerhans type (CD1a and CD207), myeloid (CD1c and CD141), and plasmacytoid (CD303 and CD304) dendritic cell subsets in oral mucosa of allergic and non-allergic individuals. Allergic individuals have more CD141+ myeloid cells in epithelium and more CD1a+ Langerhans cells in the lamina propria compared to healthy controls, but similar numbers for the other DC subtypes. Our data are the first to describe the presence of CD303+ plasmacytoid DCs in human oral mucosa and a dense intraepithelial network of CD141+ DCs. The number of Langerhans type DCs (CD1a and CD207) and myeloid DCs (CD1c), was higher in the oral mucosa than in the nasal mucosa of the same individual independent of the atopic status.</p>
Candida albicans commensalism in the oral mucosa is favoured by limited virulence and metabolic adaptation.
<p>Original data linked to Lemberg, Martinez de San Vicente, Fróis-Martins, et al., PLoS Pathogens, 2022.</p> <p>Transcriptomic data linked to this paper are deposited on the NCBI BioProject PRJNA491801 (https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA491801)</p>
The Immunosuppressive Landscape of the Gastric Mucosa under Helicobacter pylori Infection
<p>Helicobacter pylor (H. pylori) infection triggers a complex interplay between adaptive immune responses and immune suppression. However, these combined reactions typically fail to eliminate the infection. The immune suppressive mechanisms underlying H. pylori infection at the single cell level and spatial resolution remain poorly understood. In this study, we performed single-cell RNA sequencing of the gastric mucosa from both H. pylori-infected individuals and uninfected controls. By integrating spatially resolved transcriptomics data, we identified a conserved continuum spanning from normal gastric mucosa to inflammatory regions, intestinal metaplasia, and gastric cancer. We observed spatial microenvironment heterogeneity of gastric mucosa across different pathological stages spanning beyond that previously appreciated in H. pylori infection. Through comparative analysis, We identified several pathways of T cell exhaustion and observed that the presence of exhaustion-like mucosal-associated invariant T (MAIT) cells correlates with an inflammatory environment, increased myeloid cell activity, Th17 cell expansion, and upregulation of cytokine-associated pathways. Additionally, we traced the progression of intestinal metaplasia in epithelial cells, noting the accumulation of lipid-associated enterocytes, which may interact with immune cells and contribute to the immune suppressive microenvironment. Overall, our findings offer new insights into the pathogenic mechanisms of H. pylori and suggest potential avenues for developing novel immunoprophylactic strategies.</p>
The Path from Nasal Tissue to Nasal Mucosa on Chip Part 2- Advanced Microfluidic Nasal In Vitro Model for Drug Absorption Testing
<p><strong>Abstract: </strong>The nasal mucosa, being accessible and highly vascularized, opens up new opportunities for the systemic administration of drugs. However, due to several protective functions like the mucociliary clearance, this physiological barrier is a difficult obstacle for drug candidates to overcome. For this reason, effective testing procedures are required in the preclinical phase of pharmaceutical development. Based on a recently reported immortalized porcine nasal epithelial cell line, we developed a test platform based on a tissue-compatible microfluidic chip. A biomimetic glass chip equipped with a controlled bidirectional airflow to induce a physiologically relevant wall shear stress on the epithelial cell layer was microfabricated. By developing a membrane transfer technique, the epithelial cell layer could be pre-cultivated in a static holder prior to cultivation in the microfluidic environment. The dynamic cultivation within the chip showed a homogenous distribution of the mucus film on top of the cell layer and a significant increase of cilia formation compared to static cultivation condition. In addition, the recording of the ciliary transport mechanism by micro particle image velocimetry was successful. Using FITC-dextran 4000 as an example, it was shown that this nasal mucosa on a chip is suitable for permeation studies. The obtained permeation coefficient was in the range of values determined by means of other established in vitro and in vivo models. The novel nasal mucosa on chip can in future be automated and used as a substitute for animal testing.</p>
CosMx Spatial transcriptome dataset of human gastric mucosa
<p>This dataset contains the spatial transcriptome dataset of human gastric mucosa obtained by CosMx</p> <p>A zip file contains the following folders and files:</p> <p><strong>Folders</strong></p> <p>- CellComposite folder: the composite immunofluorescent images of each FOV.</p> <p>- CellLabels folder: the cell definitions images for each FOV determined during cell segmentation.</p> <p>- CellOverlay folder: the cell boundary images for each FOV determined during cell segmentation.</p> <p>- CompartmentLabels folder: the subcellular compartment images for each FOV determined during cell segmentation. The compartment types are as follows: 0. Extracellular, 1. Nuclear, 2. Membrane, 3. Cytoplasmic</p> <p>- RawMorphologyImages folder: raw morphological TIF images for each FOV</p> <p> </p> <p><strong>Files</strong></p> <p>- Run5458_{sample_name}_exprMat_file.csv: cell expression matrix.</p> <p>- Run5458_{sample_name}_fov_positions_file.csv: each FOV relative position within global structure.</p> <p>- Run5458_{sample_name}_metadata_file.csv: the metadata of each cell.</p> <p>- Run5458_{sample_name}_tx_file.csv: the transcript file for each target gene and its position.</p> <p>- Run5458_{sample_name}-polygons.csv: the segmentation polygon file.</p> <p> </p> <p><strong>Citation</strong></p> <p>If you use this dataset for your research, please cite our paper.</p> <p>Ayumu Tsubosaka, Daisuke Komura, Miwako Kakiuchi, Hiroto Katoh, Takumi Onoyama, Asami Yamamoto, Hiroyuki Abe, Yasuyuki Seto, Tetsuo Ushiku, Shumpei Ishikawa, Stomach encyclopedia: Combined single-cell and spatial transcriptomics reveal cell diversity and homeostatic regulation of human stomach, Cell Reports, Volume 42, Issue 10, 2023, 113236, https://doi.org/10.1016/j.celrep.2023.113236.</p>
Phonatory Movement of the Pharyngoesophageal Mucosa in Laryngectomy Patients
ClinicalTrials.gov study NCT05561920. IPD Sharing: NO. Countries: 1. Publications: 8.
MAGNET (Magnetically Controlled Capsule for Assessment of Gastric Mucosa in Symptomatic Patients)
ClinicalTrials.gov study NCT04724291. IPD Sharing: NO. Countries: 1. Publications: 3.
Evaluating the Safety, Pharmacokinetics, and Anti-Viral Activity of VRC01 and VRC01LS in the Serum and Mucosa of Healthy, HIV-Uninfected Adults
ClinicalTrials.gov study NCT02797171. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Induction With Misoprostol: Oral Mucosa Versus Vaginal Epithelium (IMPROVE)
ClinicalTrials.gov study NCT02408315. IPD Sharing: YES. Countries: 1. Publications: 3.
Comparison of Two Different Surgical Approaches To Increase Peri-Implant Mucosa Thickness
ClinicalTrials.gov study NCT02450383. IPD Sharing: NO. Countries: 1. Publications: 1.
Influence of Mucosa Tissue Thickness on Marginal Bone Loss of Implants With Smooth Collars
ClinicalTrials.gov study NCT02925078. IPD Sharing: NO. Countries: 1. Publications: 12.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.