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Dataset results
39 results for “NUSINERSEN”
dataset relate to article "Quality of life assessment in adult spinal muscular atrophy patients treated with nusinersen"
<p>Excel file with raw data of the INQoL scale scores for each domain, for each patient, before and after nusinersen treatment</p>
Phase IIIb, Open-label, Multi-center Study to Evaluate Safety, Tolerability and Efficacy of OAV101 Administered Intrathecally to Participants With SMA Who Discontinued Treatment With Nusinersen or Ris
ClinicalTrials.gov study NCT05386680. IPD Sharing: YES. Countries: 9. Publications: 1.
DATASET RELATED TO ARTICLE "Muscle quantitative MRI in adult SMA patients on nusinersen treatment_ a longitudinal study"
<p>Excel file with raw data of muscle fat fraction before and after nusinersen treatment</p>
A Study for Participants With Spinal Muscular Atrophy (SMA) Who Previously Participated in Nusinersen (ISIS 396443) Investigational Studies
ClinicalTrials.gov study NCT02594124. IPD Sharing: Not stated. Countries: 14. Publications: 0.
A Study of Multiple Doses of Nusinersen (ISIS 396443) Delivered to Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy
ClinicalTrials.gov study NCT02386553. IPD Sharing: Not stated. Countries: 7. Publications: 2.
Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy
ClinicalTrials.gov study NCT04089566. IPD Sharing: YES. Countries: 18. Publications: 3.
A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Participants With Later-onset Spinal Muscular Atrophy (SMA)
ClinicalTrials.gov study NCT02292537. IPD Sharing: Not stated. Countries: 10. Publications: 2.
An Open-label Safety, Tolerability and Dose-Range Finding Study of Multiple Doses of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy
ClinicalTrials.gov study NCT01703988. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study to Assess the Safety and Tolerability of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA).
ClinicalTrials.gov study NCT02462759. IPD Sharing: Not stated. Countries: 2. Publications: 1.
A Study to Assess the Efficacy, Safety and Pharmacokinetics of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy (SMA)
ClinicalTrials.gov study NCT01839656. IPD Sharing: Not stated. Countries: 2. Publications: 3.
A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy
ClinicalTrials.gov study NCT02193074. IPD Sharing: Not stated. Countries: 13. Publications: 4.
Muscle MRI in two SMA patients on nusinersen treatment: A two years follow-up
<p><strong>Introduction: </strong>The effects of nusinersen in adults with SMA rely on neuromotor function scales and qualitative assessments. There are limited clinical or imaging data on muscle changes over time.</p> <p><strong>Methods: </strong>Two adult SMA patients underwent clinical assessments including measures of upper and lower limb function with Revised Upper Limb Module (RULM) and Hammersmith Function Motor Scale Expanded (HFMSE); both patients were also studied with whole-body muscle MRI (T1-weighted and Diffusion Tensor Imaging/DTI sequences), at baseline and after 10 and 24 months from the beginning of treatment with nusinersen.</p> <p><strong>Results: </strong>After two years of treatment, HFMSE and RULM scores were stable in both patients. DTI sequences revealed an increased number, length and organization of muscle fiber tracks, and Fractional Anisotropy (FA) values showed a significant reduction after 10 and 24 months from baseline, in their corresponding maps.</p> <p><strong>Discussion: </strong>Muscle DTI imaging seems to play an interesting role to monitor treatment effects over time in adult SMA patients.</p>
A Study to Learn About the Effect of Nusinersen (BIIB058) Given as Injections to Children With Spinal Muscular Atrophy (SMA) Who Were Previously Treated With Onasemnogene Abeparvovec (RESPOND)
ClinicalTrials.gov study NCT04488133. IPD Sharing: YES. Countries: 5. Publications: 1.
Efficacy and Safety of Apitegromab in Patients With Later-Onset Spinal Muscular Atrophy Treated With Nusinersen or Risdiplam
ClinicalTrials.gov study NCT05156320. IPD Sharing: NO. Countries: 9. Publications: 1.
An Open-label Safety, Tolerability, and Dose-range Finding Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA)
ClinicalTrials.gov study NCT01494701. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effect of Nusinersen on Adults With Spinal Muscular Atrophy
ClinicalTrials.gov study NCT03878030. IPD Sharing: NO. Countries: 1. Publications: 2.
An Open-label Safety and Tolerability Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA) Who Previously Participated in ISIS 396443-CS2 (NCT01703988) or ISIS 396443-C
ClinicalTrials.gov study NCT02052791. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Hyperkinetic Movements in Patients With Disease of Motor Neurons and Their Response to Treatment With Nusinersen
ClinicalTrials.gov study NCT04825119. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Risdiplam in Patients With Spinal Muscular Atrophy Previously Treated With Nusinersen
ClinicalTrials.gov study NCT05522361. IPD Sharing: NO. Countries: 1. Publications: 3.
Non-Interventional, Postmarketing Surveillance Study of Nusinersen Sodium Injection
ClinicalTrials.gov study NCT04419233. IPD Sharing: YES. Countries: 1. Publications: 1.
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International Brain Laboratory public data
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OpenNeuro
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