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Dataset results
23 results for “Nephrogenesis”
Dataset related to: Post-translational modifications by SIRT3 de-2-hydroxyisobutyrylase activity regulate glycolysis and enable nephrogenesis
<p>The file contains all the dataset included in the manuscript, divided by figure in each tab</p> <p> </p> <p><strong>Abstract</strong></p> <p>Abnormal kidney development leads to lower nephron number, predisposing to renal diseases in adulthood. In embryonic kidneys, nephron endowment is dictated by the availability of nephron progenitors, whose self-renewal and differentiation require a relatively repressed chromatin state. More recently, NAD<sup>+</sup>-dependent deacetylase sirtuins (SIRTs) have emerged as possible regulators that link epigenetic processes to the metabolism. Here, we discovered a novel role for the NAD<sup>+</sup>-dependent deacylase SIRT3 in kidney development. In the embryonic kidney, SIRT3 was highly expressed only as a short isoform, with nuclear and extra-nuclear localisation. The nuclear SIRT3 did not act as deacetylase but exerted de-2-hydroxyisobutyrylase activity on lysine residues of histone proteins. Extra-nuclear SIRT3 regulated lysine 2-hydroxyisobutyrylation (Khib) levels of phosphofructokinase (PFK) and Sirt3 deficiency increased PFK Khib levels, inducing a glycolysis boost. This altered Khib landscape in <em>Sirt3<sup>-/-</sup></em> metanephroi was associated with decreased nephron progenitors, impaired nephrogenesis and a reduced number of nephrons. These data describe an unprecedented role of SIRT3 in controlling early renal development through the regulation of epigenetics and metabolic processes.</p>
HUMAN FETAL KIDNEY ORGANOIDS MODEL EARLY NEPHROGENESIS AND NOTCH-DRIVEN CELL FATE [scRNA-seq]
GEO Series GSE300166. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
HUMAN FETAL KIDNEY ORGANOIDS MODEL EARLY NEPHROGENESIS AND NOTCH-DRIVEN CELL FATE [scRNA-Seq 2]
GEO Series GSE300309. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Maternal Malnutrition in Mice Impairs Nephrogenesis by Disrupting DNA Methylation of Regulatory Regions
GEO Series GSE249393. Mus musculus. 8 samples. Type: Methylation profiling by high throughput sequencing.
Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate
GEO Series GSE300015. Homo sapiens. 39 samples. Type: Expression profiling by high throughput sequencing.
HISTONE DEACETYLASES 1 AND 2 TARGET GENE REGULATORY NETWORKS OF NEPHRON PROGENITORS TO CONTROL NEPHROGENESIS.
GEO Series GSE217316. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Human kidney organoid scRNA-seq (from study: Genome-wide screening in human kidney organoids identifies novel aspects of nephrogenesis)
GEO Series GSE181595. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Human fetal kidney organoids model early human nephrogenesis and notch-driven cell fate
GEO Series GSE271315. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
Gain-of-function ENL YEATS domain mutations impede nephrogenesis through gene expression control
GEO Series GSE283435. Mus musculus. 34 samples. Type: Expression profiling by high throughput sequencing; Other.
Gain-of-function ENL YEATS domain mutations impede nephrogenesis through gene expression control [Spatial Transcriptomics]
GEO Series GSE283433. Mus musculus. 2 samples. Type: Other.
Gain-of-function ENL YEATS domain mutations impede nephrogenesis through gene expression control [RNA-seq]
GEO Series GSE266256. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA sequencing reveals differential cell cycle activity in key cell populations during nephrogenesis
GEO Series GSE158166. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Lin28/let-7 axis regulates the timig of cession of nephrogenesis
GEO Series GSE117510. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
HISTONE DEACETYLASES 1 AND 2 TARGET GENE REGULATORY NETWORKS OF NEPHRON PROGENITORS TO CONTROL NEPHROGENESIS [RNA-seq]
GEO Series GSE217315. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Progenitor Translatome Changes Coordinated by Tsc1 Increase Perception of Wnt Signals to End Nephrogenesis [10x_scRNA-seq]
GEO Series GSE173265. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Progenitor Translatome Changes Coordinated by Tsc1 Increase Perception of Wnt Signals to End Nephrogenesis
GEO Series GSE173264. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Lgr5+ve stem cells in nephrogenesis
GEO Series GSE39881. Mus musculus. 4 samples. Type: Expression profiling by array.
Progenitor Translatome Changes Coordinated by Tsc1 Increase Perception of Wnt Signals to End Nephrogenesis
GEO Series GSE173266. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Defects in nephrogenesis result in an expansion of the Foxd1+ stromal progenitor population
GEO Series GSE289696. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Neonatal nephron loss during active nephrogenesis results in altered expression of renal developmental genes and markers of kidney injury
GEO Series GSE176395. Rattus norvegicus. 16 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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