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182 results for “Neurodevelopment”
UNC-Wisconsin Neurodevelopment Rhesus Structural MRI Database
<p>A macaque brain MRI database characterizing the normal postnatal macaque brain development. This longitudinal primate database was acquired from a cohort of healthy macaque monkeys ranging from a few week olds up to 3-year-old adolescents. Website: https://data.kitware.com/#collection/54b582c38d777f4362aa9cb3</p>
UNC-Wisconsin Neurodevelopment Rhesus Structural MRI Database
<p>A macaque brain MRI database characterizing the normal postnatal macaque brain development. This longitudinal primate database was acquired from a cohort of healthy macaque monkeys ranging from a few week olds up to 3-year-old adolescents. Website: https://data.kitware.com/#collection/54b582c38d777f4362aa9cb3</p>
UNC-Wisconsin Neurodevelopment Rhesus Structural MRI Database
<p>A macaque brain MRI database characterizing the normal postnatal macaque brain development. This longitudinal primate database was acquired from a cohort of healthy macaque monkeys ranging from a few week olds up to 3-year-old adolescents. Website: https://data.kitware.com/#collection/54b582c38d777f4362aa9cb3</p> <p>This work was supported by R01 MH091645 DEVELOPMENTAL BRAIN ATLAS TOOLS AND DATA APPLIED TO HUMANS AND MACAQUES http://projectreporter.nih.gov/project_info_description.cfm?aid=8454496</p>
Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids
<p><strong>Abstract: </strong>Disruptions in the tightly regulated process of human brain development have been linked to increased risk for brain and mental illnesses. While the genetic contribution to these diseases is well established, important environmental factors have been less studied at molecular and cellular levels. In this study, we used single-cell and cell-type-specific techniques to investigate the effect of glucocorticoid (GC) exposure, a mediator of antenatal environmental risk, on gene regulation and lineage specification in unguided human neural organoids. We characterized the transcriptional response to chronic GC exposure during neural differentiation and studied the underlying gene regulatory networks by integrating single-cell transcriptomics- with chromatin accessibility data. We found lasting cell type-specific changes that included autism risk genes and several transcription factors associated with neurodevelopment. Chronic GCs influenced lineage specification primarily by priming the inhibitory neuron lineage through key transcription factors like PBX3. We provide evidence for convergence of genetic and environmental risk factors through a common mechanism of altering lineage specification.</p>
Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment
<p>Exposure to maternal immune activation (MIA) in utero is a risk factor for neurodevelopmental and psychiatric disorders. MIA-induced deficits in adolescent and adult offspring have been well characterized, however, less is known about the effects of MIA-exposure on embryo development. To address this gap, we collected high-resolution ex vivo magnetic resonance imaging (MRI) of C57BL/6 mouse embryos (gestational day [GD]18) who were prenatally exposed to MIA either early (GD9) or late (GD17) in gestation. We further examined hippocampal neuroanatomy using electron microscopy and identified differential effects due to MIA-timing. </p> <p>The data published here was collected and analyzed for the following publication available as a preprint on BioRxiv (https://www.biorxiv.org/content/10.1101/2021.07.14.452084v2). Briefly, We identify striking neuroanatomical changes in the embryo brain, particularly in the late exposed offspring. An increase in apoptotic cell density was observed in the GD9 exposed offspring, while an increase in the density of dark neurons and glia, putative markers for increased neuroinflammation and oxidative stress, was observed in GD17 exposed offspring, particularly in females. Overall, our findings integrate imaging techniques across different scales to identify differential impact of MIA-timing on the earliest stages of neurodevelopment.</p> <p>In this dataset, you will find a total of <strong>187 preprocessed structural MRIs </strong>(in MINC format) of whole embryos at gestational day 18. These embryos were exposed to poly I:C or vehicle control (0.9% sterile saline) at GD9 or 17. A multi-channel 7.0-T MRI scanner with a 40 cm diameter bore (Varian Inc., Palo Alto, CA), with a custom-built 16-coil solenoid array was used to acquire T2-weighted, gadolinium enhanced structural images at 40 μm3 resolution images from 16 samples concurrently (3D fast spin echo sequence using a cylindrical k-space acquisition; TR/TE=350/12 ms, echo train length=6, two averages, field-of-view 20 mm x 20 mm x 25 mm, matrix size=504 x 504 x 630).</p> <p>An N4 correction for B1 bias field inhomogeneities and denoising using non-local means (minc_anlm) was applied to the T2-weighted images, and the background was set to zero using minc tools. The demographics information for each animal is included in the <strong>demographics.csv</strong> file. </p> <p>The dorsal hippocampus was selected as a region of interest in which the total number and density of total cells, dark neurons, dark glia, apoptotic cells were assessed (as presented in our manuscript). This is available in the <strong>EM_raw_data_per_slice.csv</strong> and <strong>EM_average_per_mouse.csv </strong>files. </p> <p>Included in this data set are the <strong>structural MRIs in MINC format</strong>, corresponding demographics information (<strong>demographics.csv</strong>), electron microscopy data from the dorsal hippocampus (<strong>EM_raw_data_per_slice.csv</strong> and <strong>EM_average_per_mouse.csv)</strong> data, and a <strong>readme.txt</strong> file providing further detail on the data structure and content, and on how to interpret the data column titles.The raw (not-preprocessed) MINC files, as well as MINC files cropped to the head of the embryos available upon request to the authors. </p> <p>Finally, the authors would like to acknowledge the funding bodies that supported the completion of this work including the Canadian Institute for Health Research, the Fonds de Recherche du Québec en Santé, and the Healthy Brains for Healthy Lives at McGill University.</p>
Investigating the "two-hit hypothesis": effects of prenatal maternal immune activation and adolescent cannabis use on neurodevelopment in mice
<p>Prenatal exposure to maternal immune activation (MIA) and chronic adolescent cannabis use have both been identified as environmental risk factors for neuropsychiatric disorders. However, most individuals exposed to a single risk factor do not typically develop major mental illness, which suggests that multiple exposures may be required for illness onset. Here, we examine whether combined exposure to prenatal MIA and adolescent delta-9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis, lead to enduring neuroanatomical and behavioural changes in adult offspring, potentially reflecting changes in humans indicative of mental illness. </p> <p>Mice were prenatally exposed to a viral mimetic, poly I:C (5mg/kg), or vehicle at gestational day (GD)9, and then postnatally exposed to chronic THC (5mg/kg) or vehicle by intraperitoneal injections during adolescent development (postnatal day [PND]28-45). Longitudinal in vivo whole-brain magnetic resonance imaging (MRI) was performed pre-treatment, PND25, post-treatment, PND50, and in adulthood, PND85, followed by a series of behavioural tests aimed at assessing anxiety-like and locomotor, social, and sensorimotor gating behaviour. Post-mortem assessment of cannabinoid (CB)1 and 2 receptor expressing cells was performed in developmentally altered regions identified by MRI (anterior cingulate and somatosensory cortices, striatum, and hippocampus). We hypothesized that there would be differential, but synergistic effects of each exposure.</p> <p>Briefly, we found subtle deviations in neurodevelopmental trajectory and subthreshold anxiety-like behaviours were observed in mice exposed to both risk factors. Sex-dependent effects were observed in patterns of shared brain-behaviour covariation, suggesting that exposure to MIA and THC may affect males and females in different ways. Density of CB1 and CB2 receptor positive cells was significantly decreased in all regions assessed for all mice exposed to either one or both risk factors, relative to controls.</p> <p>These findings suggest that there may be a cumulative effect of risk factor exposure on gross neuroanatomical and behavioural development, and that the endocannabinoid system may be sensitive to both prenatal MIA, adolescent THC, or the combination. For full details, see our publication: .</p> <p>In this dataset, you will find a total of 243 preprocessed structural MRIs (in MINC format) acquired at postnatal day ~25, ~50, and ~85 in mice exposed to poly I:C or vehicle control (0.9% sterile saline) at GD9, and then postnatally treated with vehicle or THC from PND 28-45. These are T1-weighted structural images at 100 micron isotropic resolution acquired on a 7 Tesla Bruker Biospec 70/30; matrix size of 180 x 160 x 90; 14.5 minutes, 20 degrees and TE/TR of 4.5/20 ms (2 averages, ~14 minutes). Anesthesia was induced with 3% isoflurane in oxygen and a (0.075 mg/kg bolus) dexmedetomidine injection. Anesthesia was maintained during the scan between 1.5-0.5% isoflurane, and a constant infusion of dexmedetomidine (0.05mg/kg/h continuous mg/kg during scan). T1-weighted scans were preprocessed by stripping native coordinates, flipping left-right to maintain fidelity, denoising, correcting inhomogeneities in the bias field using the N4 algorithm, and registering in LSQ6 alignment (i.e. 6 degrees of freedom are allowed for imagine alignment: translations and rotations along x, y, and z dimensions). The demographics information for each animal is included in the demographics.csv file. </p> <p>Behavioural tests were performed following the postnatal day 85 scans in all animals with a 2 day rest period. These include: open field test, three chambered social approach, and prepulse inhibition. The data for all of these tests is presented in its own individual .csv spreadsheet.</p> <p>Included in this data set are the structural MRIs in MINC format, the behavioural .csv data, and a readme.txt file providing further detail on the data structure and content, and on how to interpret the data column titles. DICOMS are also available for the structural MRI data, as are the raw (not-preprocessed) MINC files, available upon request to the authors. </p> <p>Finally, the authors would like to acknowledge the funding bodies that supported the completion of this work including the Canadian Institute for Health Research, the Fonds de Recherche du Québec en Santé, and the Healthy Brains for Healthy Lives at McGill University.</p>
MSME T2 data from the Ferret Interactive Integrated Neurodevelopment Atlas
<p>The first days after birth in ferrets provide a unique view of the development of a complex brain. Unlike mice, ferrets develop a rich pattern of deep neocortical folds and cortico-cortical connections. Unlike humans and other primates, whose brains are well differentiated and folded at birth, ferrets are born with a very immature and completely smooth neocortex: folds, neocortical regionalisation and cortico-cortical connectivity develop in ferrets during the first days after birth. After a period of fast neocortical expansion, during which brain volume increases by up to a factor of 4 in 2 weeks, the ferret brain reaches its adult volume at about 6 weeks of age. This dataset contains brain MRI T2 data from 28 ferrets from P0 to Adults. It can be visualised at http://brainbox.pasteur.fr/project/FIIND.</p>
Vitamin B12, Neurodevelopment and Growth in Nepal
ClinicalTrials.gov study NCT02272842. IPD Sharing: YES. Countries: 1. Publications: 9.
Joint profiling of cell morphology and gene expression during in vitro neurodevelopment
<p>Cell Painting processed data for "Joint profiling of cell morphology and gene expression during in vitro neurodevelopment".</p>
Neonatal brain dynamic functional connectivity: impact of preterm birth and association with early childhood neurodevelopment (data)
<p>Neonatal brain dynamic functional connectivity: impact of preterm birth and association with early childhood neurodevelopment</p>
Something in the water: Aquatic microbial communities influence the larval amphibian gut microbiota, neurodevelopment, and behavior
<p>Microorganisms colonize the gastrointestinal tract of animals and establish symbiotic host-associated microbial communities that influence vertebrate physiology. More specifically, these gut microbial communities influence neurodevelopment through the microbiota-gut-brain (MGB) axis. We tested the hypothesis that larval amphibian neurodevelopment is affected by the aquatic microbial community present in their housing water. Newly hatched Northern Leopard Frog (<em>Lithobates pipiens</em>) tadpoles were raised in pond water that was unmanipulated (natural) or autoclaved. Tadpoles raised in autoclaved pond water had a gut microbiota with reduced bacterial diversity and altered community composition, had decreased behavioral responses to sensory stimuli, were larger in overall body mass, had relatively heavier brains, and had altered brain shape when compared with tadpoles raised in natural pond water. Further, the diversity and composition of the gut microbiota was associated with tadpole behavioral responses and brain measurements. Our results suggest that aquatic microbial communities shape tadpole behavior and brain development, providing strong support for the occurrence of the MGB axis in amphibians. Lastly, the dramatic role played by aquatic microbial communities on vertebrate neurodevelopment and behavior should be considered in future wildlife conservation efforts.</p>
Imaging data (part 1) for the manuscript "Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice"
<p>This archive contains part 1 of the raw imaging data of the manuscript "Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice".</p>
Imaging data (part 2) for the manuscript "Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice"
<p>This archive contains part 2 of the raw imaging data of the manuscript "Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice".</p>
Current Opinion in Psychiatry - Air pollution and Neurodevelopment Paper Method and Dataset
<p>The dataset for this research was compiled through an advanced PubMed search targeting publications from a one-year period. Keywords focused on air pollution, neurodevelopment, and associated disorders. From an initial pool of 5,000 publications, filtering based on co-occurrence of relevant keywords reduced this to approximately 80 papers. VOSviewer was employed to analyze co-occurrences and generate a visual map of relationships between air pollution and child neurodevelopment. The thesaurus was applied to standardize terminology, refining the final network for detailed analysis of keyword clusters and their interactions.</p>
Reducing Pain and Promoting Neurodevelopment Among Preterm Neonates
ClinicalTrials.gov study NCT04366102. IPD Sharing: YES. Countries: 1. Publications: 3.
Efficacy and Safety of Circadin® in the Treatment of Sleep Disturbances in Children With Neurodevelopment Disabilities
ClinicalTrials.gov study NCT01906866. IPD Sharing: Not stated. Countries: 5. Publications: 2.
Maternal Adversity, Vulnerability and Neurodevelopment
ClinicalTrials.gov study NCT03434457. IPD Sharing: NO. Countries: 1. Publications: 43.
ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)
ClinicalTrials.gov study NCT05388708. IPD Sharing: YES. Countries: 11. Publications: 7.
Data from: Exploratory study evaluating the relationships between perinatal adversity, oxidative stress, and infant neurodevelopment across the first year of life data
Open the record for dataset details and reuse information.
Data from: Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment
Open the record for dataset details and reuse information.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.